2022 Fiscal Year Final Research Report
The role of TEM8 in the regulatory mechanism of liver regeneration and its utilization in the development of innovative therapies
Project/Area Number |
20K22964
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0905:Surgery of the organs maintaining homeostasis and related fields
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Research Institution | Nippon Medical School |
Principal Investigator |
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Project Period (FY) |
2020-09-11 – 2023-03-31
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Keywords | 肝臓病 / 肝炎 / インテグリン類似蛋白 |
Outline of Final Research Achievements |
The objective of this study was to elucidate the role of Tumor Endothelial Marker 8 (TEM8) in the regulatory mechanism of liver regeneration and establish a research platform for the development of novel therapies for chronic liver diseases. We generated NAFLD/NASH-induced mice fed a choline-deficient, methionine-reduced, high-fat diet and analyzed TEM8 expression in the liver using immunohistochemistry. Our findings indicated that TEM8 was expressed on bile ducts (capillary to interlobular bile ducts). These results suggest that TEM8 may serve as an indicator of bile duct injury in the liver of NASH.
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Free Research Field |
消化器病学、肝臓病学、組織学
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、インテグリン類似蛋白であるTEM8が肝障害に伴って、その発現および局在を変化させることを免疫組織学的に明らかにし、TEM8がNAFLD/NASH病態時における新たな胆管障害マーカーとなり得ることを示唆する先駆け研究となった。 TEM8は肝前駆細胞から胆管形成ネットワークを構築する肝再生機序における因子として機能する可能性が高く、この研究の継続発展は肝再生医療への貢献が期待できる。
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