Identification of mechanism of castration resistant growth of prostate cancer cells by innervation

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22970
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: Chiba University
• Principal Investigator: GOTO YUSUKE 千葉大学, 大学院医学研究院, 助教 (00710576)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 前立腺癌 / 去勢抵抗性前立腺癌 / 神経依存的増殖

Outline of Final Research Achievements

The aim of study was to find novel mechanisms of innervation-driven castration resistant growth of prostate cancer. LNCaP was cultured under castrated condition, and RNA-seq was performed. Functional RNA was extracted, and we perfomed database analysis to find functional RNA that regulates muscarinic receptors. We found that abberant expression of functional RNAs lead to abberant expression of muscarinic receptors.

Free Research Field

泌尿器腫瘍学

Academic Significance and Societal Importance of the Research Achievements

神経依存的去勢抵抗性前立腺癌増殖のメカニズムとして、機能性RNAの発現異常が関与していることを見出した。臨床において、去勢抵抗性前立腺癌の治療に難渋することは少なくなく、アンドロゲン非依存的前立腺癌増殖の一つの機序が明らかになった。