Development of long-term indwelling ureteral stent with excellent safety by coating materials similar to biological components

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K22979
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: Kobe University
• Principal Investigator: Yang Youngmin 神戸大学, 医学部附属病院, 医員 (20884050)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: 尿路感染症 / 尿管ステント

Outline of Final Research Achievements

In this research, by coating ureteral stents with biosimilar materials with high bioaffinity and low adhesion to foreign substances, by suppressing the adhesion of stones that are considered to be the most harmful to patients, it can be safely retained for a longer period of time than ready-made products, and the frequency of infection and kidney function decline due to blockage during placement is also reduced. Evaluated in vitro and in vivo. Evaluation of the effect of preventing stone adhesion in vitro using artificial urine, and evaluation of the in vivo indentation inhibitory effect and biocompatibility of stone adhesion in vivo by placement in the bladder in urinary tract stone model rats, It was shown that new ureteral stents in vitro and in vivo can prevent stone adhesion in a longer period of 4 weeks than existing products.

Free Research Field

尿路性器感染症分野

Academic Significance and Societal Importance of the Research Achievements

本コーティングステントは結石形成のメカニズムの2つを抑制する親水性コーティング（細菌、蛋白質の付着を抑制）とpHコントロールコーティング（アルカリ性尿の環境を作らない）を1つのコーティング手法で同時に達成することが技術的に有利な点である。これはコーティング材料費用が半分で済み、経済的に有利な点にもなる。また本in vitroの結果は既製品ステントに比較し、明らかな結石、細菌、蛋白質の異物付着の抑制効果を示し、この効果が長期間維持でき、現在の3か月の最長留置期間を延長でき、患者さんの負担を軽減し、医療経済面でも効果が高い。