2022 Fiscal Year Final Research Report
Elucidating the Effects of Aging Changes on the Pathophysiology of Allergic Rhinitis
| Project/Area Number |
20K22995
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
0906:Surgery related to the biological and sensory functions and related fields
|
|---|
| Research Institution | Teikyo University (2022)
The University of Tokyo (2020-2021) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-09-11 – 2023-03-31
|
| Keywords | アレルギー性鼻炎 / 加齢 |
|---|
| Outline of Final Research Achievements |
The purpose of this study is to analyze antigen-specific IgE, immunocompetent cells, cytokines, and lipid mediators that contribute to the pathogenesis of allergic rhinitis, a type I allergic disease, in the nasal mucosa. However, in recent years, the prevalence of allergic rhinitis has been increasing in actual clinical practice. However, little is known about the effects of age-related changes in immune responses and pathophysiology at the local nasal mucosa on the pathogenesis of allergic rhinitis, and these unexplored aspects were examined.
Translated with www.DeepL.com/Translator (free version)
|
| Free Research Field |
耳鼻咽喉科学
|
| Academic Significance and Societal Importance of the Research Achievements |
高齢者は従来アレルギー性鼻炎の有病率は低く、これは幼少時の生育環境に起因すると考えられてきたが、一方中年層の鼻炎有病者が高齢化し、高齢者のアレルギー性鼻炎有病率も増加傾向にある。I型アレルギーは加齢により重症度が下がるといわれているが、アレルギー性鼻炎の加齢による変化を包括的にとらえた取り組みは乏しい。アレルギー性鼻炎の分子病態における加齢の影響結果をもとに炎症メディエーターを人為的に制御する新たな治療法の開発の可能性を探るという点で研究の社会実装にも貢献できる可能性がある。
|
