Immunological Effects of HMGB1 on Periodontal Disease and Novel Periodontal Disease Treatment by HMGB1 Regulation

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K23054
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Okayama University
• Principal Investigator: Ideguchi Hidetaka 岡山大学, 医歯薬学域, 助教 (80779421)
• Project Period (FY): 2020-09-11 – 2023-03-31
• Keywords: HMGB1 / 歯周炎 / M1マクロファージ

Outline of Final Research Achievements

HMGB1 is important molecule involved in various acute and chronic inflammatory diseases by promoting cytokine production as inflammatory mediator. In periodontitis, anti-HMGB1 antibodies have been reported to suppress inflammation and alveolar bone resorption, but the detailed mechanism remains unclear. In this study, we focused on the association between macrophage and HMGB1, which plays an important role in the pathogenesis of many inflammatory diseases, and investigated the immunological effects of HMGB1 on periodontal tissue in-vivo and in-vitro.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果，歯周炎組織においてHMGB1を抑制すると，マクロファージのM1タイプへの分化が減少した。また，歯周炎組織中の炎症性サイトカインの遺伝子発現は減少し，歯槽骨吸収は抑制された。これは，HMGB1の歯周炎の病態における複雑な免疫学的メカニズムを解明する一助となる。