Development of new periodontal treatment using Schwann cell-derived factor Schwann cell-derived factor

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K23115
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Kyushu University
• Principal Investigator: Itoyama Tomohiro 九州大学, 大学病院, 助教 (50884433)
• Project Period (FY): 2020-09-11 – 2022-03-31
• Keywords: シュワン細胞

Outline of Final Research Achievements

In periodontal tissues damaged by severe periodontitis or trauma, alveolar bone resorption, which is the supporting tissue for teeth, progresses, leading to tooth extraction in many cases. It is desirable to develop a treatment method that can efficiently regenerate periodontal tissues that have been extensively lost. The applicants have shown that Schwann cells collect in injured periodontal tissues and that culture supernatants of Schwann cell lines significantly promote osteoblastic differentiation of preosteoblasts and periodontal ligament stem cells compared to those of periodontal ligament cell lines, but factors having this effect have not been identified. In this study, the culture supernatant of YST-1 cells was subjected to proteomic analysis, and VGF was identified as the first candidate for the factor. Detailed analysis will be performed in the future.

Free Research Field

歯科保存学

Academic Significance and Societal Importance of the Research Achievements

重度の歯周炎や外傷等により傷害を受けた歯周組織では、歯の支持組織である歯槽骨吸収が進行して抜歯に至るケースも少なくない。広範囲に喪失した歯周組織を効率よく再生することができる治療法の開発が望まれている。本研究では、前骨芽細胞および歯根膜幹細胞を骨芽細胞に誘導する因子の同定を目的とし、新たな歯周組織を再生する治療法の開発につながる知見を得ることが学術的および社会的意義である。