2021 Fiscal Year Final Research Report
Early pathogenesis of non-alcoholic steatohepatitis in a short-term high-fat diet model.
Project/Area Number |
20K23272
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0909:Sports sciences, physical education, health sciences, and related fields
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Research Institution | Aichi Medical University |
Principal Investigator |
Nanizawa Eri 愛知医科大学, 医学部, 助教 (10879464)
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Project Period (FY) |
2020-09-11 – 2022-03-31
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Keywords | NASH / NAFLD / 高脂肪食 / 高糖質食 / 急性肝障害 |
Outline of Final Research Achievements |
A study in 2020 showed that short-term high-carbohydrate diet intake also increased susceptibility to hepatotoxic stimulation, as did high-fat diet intake. In 2021, the data were validated for reproducibility and the results of these studies were submitted to an international journal. We are also analysing serum and liver metabolites in short-term high-fat diet and high-carbohydrate diet models and will pursue the relationship between some metabolites and inflammation and coagulation in the future.
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Free Research Field |
肝臓学
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Academic Significance and Societal Importance of the Research Achievements |
一般的に従来の研究では、長期間(2-4ヶ月)の高脂肪食や高糖質食の摂取により、脂肪肝やNASHの病態を呈した上で、病態の解析が行われてきた。しかしながら本研究では、4日間という超短期的な高脂肪食および高糖質食の摂取においても、肝臓が脆弱な状態(凝固能が亢進し、炎症の誘発が起こりやすい状態)に変化することを発見し、さらにはこの2つの食餌性因子が、異なるメカニズムによってNASH発症のリスク因子となることを立証した。この研究は病態の超早期段階に着目したものであるため、食餌による肝臓の脆弱状態を誘発するメカニズムを解明できる可能性が高い。
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