2022 Fiscal Year Final Research Report
Effects of gait using functional electrical stimulation on the cortical excitability
Project/Area Number |
20K23298
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0909:Sports sciences, physical education, health sciences, and related fields
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Research Institution | Fujita Health University |
Principal Investigator |
Yuasa Akiko 藤田医科大学, 医学部, 研究員 (30878468)
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Project Period (FY) |
2020-09-11 – 2023-03-31
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Keywords | 経頭蓋磁気刺激 / 電気刺激 / 一次運動野 / 皮質脊髄路 |
Outline of Final Research Achievements |
First, in the Experiment 1, the systematic investigation of cortical motor representation was conducted to establish the measurement of excitability of the corticospinal tract using transcranial magnetic stimulation in healthy participants. Our original research plan was to target the lower-limb muscles during walking, but due to some critical technical issues such as prevention of infection, we changed the plan to target the muscles of the upper limb. Next, in the Experiment 2, the effects of peripheral nerve electrical stimulation of medial nerve and ulnar nerve on the excitability of the motor cortex were investigated in healthy adults. As a result, the peripheral stimulation resulted in the decrease in the motor map area of the hand muscles, but it was only observed in the medial nerve stimulation.
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Free Research Field |
リハビリテーション関連分野
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Academic Significance and Societal Importance of the Research Achievements |
これまでにTMSマッピングを用いた体部位再現領域の検証は国内外で広く検証されているが、実験1のシステマティックなアプローチにより、筋の組み合わせと至適強度の選定という詳細な検証を行ったものは我々の知る限り例はない。今回の検証結果は今後のTMSマッピング研究に応用可能であり、意義があると言える。実験2では当初の予定と異なる形となったが、電気刺激が運動出力の中枢である一次運動野に与える効果について精緻な検証を行った。TMSマッピング手法と組み合わせた新しい検証により、電気刺激の効果のメカニズムまで踏み込むことができ、今まで十分に明らかとなっていなかった中枢神経系への変調を捉えることが可能となった。
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