2023 Fiscal Year Final Research Report

Development of preclinical magnetic resonance imaging system for oxygen and energy metabolism as an imaging biomarker

Research Project

PDF

Project/Area Number	20KK0253
Research Category	Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 90:Biomedical engineering and related fields
Research Institution	Gifu University
Principal Investigator	Matsuo Masayuki 岐阜大学, 大学院医学系研究科, 教授 (40377669)
Co-Investigator(Kenkyū-buntansha)	兵藤文紀岐阜大学, 大学院医学系研究科, 教授 (10380693) 加藤博基岐阜大学, 大学院医学系研究科, 准教授 (70377670) 野田佳史岐阜大学, 医学部附属病院, 講師 (60643020) 川田紘資岐阜大学, 医学部附属病院, 准教授 (00585276) 河合信行岐阜大学, 医学部附属病院, 講師 (20724561) 田中秀和山口大学, 大学院医学系研究科, 教授 (30509782)
Project Period (FY)	2020-10-27 – 2024-03-31
Keywords	放射線治療 / MRI / 超偏極
Outline of Final Research Achievements	Oxygen and energy metabolism are expected to be utilized as new imaging biomarkers for pathological imaging because they are essential for maintaining homeostasis in living organisms and are sensitively altered in various diseases and treatments. In this study, we advanced research on imaging cancer metabolism and early drug efficacy evaluation of anticancer drugs using a dissolution hyperpolarization method, which amplifies MRI sensitivity by more than 10000-fold. This research was conducted in collaboration with Dr. Murali and colleagues at the National Cancer Institute (NCI/NIH), applying their contrast agent protocol. We applied this protocol to detect the effects of anticancer drugs in pancreatic cancer model mice at the preliminary stage of morphological changes induced by MRI.
Free Research Field	放射線治療
Academic Significance and Societal Importance of the Research Achievements	放射線や抗がん剤によるがん治療の効果を評価するにはMRIやCTなどを用いた解剖学的評価が常用されている。本研究で開発した早期薬効評価技術により、従来の方法に比べ飛躍的に早期に治療効果を評価できる可能性があり、がん治療の選択肢の拡充やQOLの向上に貢献すると考えられる。