2023 Fiscal Year Final Research Report
Elucidation of interaction mechanism between feeding and respiration
| Project/Area Number |
20KK0353
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2021 – 2023
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| Keywords | 嚥下 / 呼吸 / 孤束核 / 迷走神経 / 喉頭 / 咽頭 / 食道 / 動物 |
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| Outline of Final Research Achievements |
This study aimed to clarify the relationship between feeding and respiration and the neural mechanism of initiation of swallowing. Male rodents were used in this study. Using electrophysiological, neuropharmacological and histological approaches, we tried to identify the region within the nucleus of the solitary tract (nTS) involved in the initiation of swallowing and to investigate the projection area within the nTS from the pharynx, larynx and esophagus which are regions to initiate swallowing. The results suggest that medial, commissural and ventrolateral subnuclei within the nTS receive inputs from the pharynx, larynx and esophagus and are involved in the initiation of mechanically evoked swallows. Further research that specifically targets these subnuclei will help to uncover the pathological mechanism of dysphagia and to facilitate the development of novel rehabilitation methods for patients with dysphagia.
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| Free Research Field |
摂食嚥下障害学
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| Academic Significance and Societal Importance of the Research Achievements |
嚥下は延髄にある嚥下中枢パターン発生器により制御される運動である．これまでに延髄の孤束核が嚥下誘発に関与することは報告されていたが，自然刺激で誘発される嚥下に孤束核内のどの領域が関与しているかは不明であった．本研究から，孤束核の内側亜核，交連亜核，腹外側亜核が機械刺激で誘発される嚥下反射に重要な役割を果たすことがわかった．これら領域を標的とした研究を進めることは，嚥下障害の病態解明や新規治療法の開発へとつながると期待できる．
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