2011 Fiscal Year Final Research Report
In vivo molecular analysis of tolerant ability in tardigrades
| Project/Area Number |
21200043
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
Chemistry related to living body
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 極限環境耐性 / クマムシ / 次世代シークエンサー / 変異体 |
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| Research Abstract |
Tardigrades enter an ametabolic dehydrated state called anhydrobiosis upon desiccation and tolerate various extreme environmental stresses in such a state. The molecular mechanisms of the tolerant ability remain unknown and no in vivo analyses have been conducted. Here, we isolated pigment-deficient mutant of anhydrobiotic tardigrade for the first time and revealed that the mutant is more sensitive to radiation stress than wildtype animal. Massive sequencing and comparison with the wildtype genome revealed multiple mutated genes. Furthermore, we characterized the property of the pigments of wildtype tardigrades and these pigments could be good clues to support radiation tolerance in animals.
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