2011 Fiscal Year Final Research Report
Genome-wide mapping of cis-regulatory elements conserved in vertebrates
| Project/Area Number |
21200064
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
Genetics/Genome dynamics
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
OGINO Hajime 奈良先端科学技術大学院大学, バイオサイエンス研究科, 研究チーム長 (10273856)
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| Co-Investigator(Renkei-kenkyūsha) |
OCHI Haruki 山形大学, 医学部・教育研究支援センター, 助教 (00505787)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ゲノム / 遺伝子 / 発現制御 / 発生・分化 / 比較ゲノム / 進化 |
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| Research Abstract |
We performed cis-regulatory analyses of genes involved in development and disease in a genome-wide manner, using comparative genomics approach and an efficient transgenesis technique in Xenopus. Conserved enhancers were identified in a variety of genes including Pax family and Polycomb-related genes. Furthermore, comparative functional analysis between the vertebrate and amphioxus cis-regulatory elements revealed that silencer innovation, rather than enhancer degeneration, was crucial for the diversification of paralog expression during vertebrate evolution.
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[Journal Article] Evolution of a tissue-specific silencer underlies divergence in the expression of pax2 and pax8 paralogues2012
Author(s)
Ochi, H., Tamai, T., Nagano, H., Kawaguchi, A., Sudou, N. and Ogino, H
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Journal Title
Nature Communications
Volume: 3
Pages: 848
Peer Reviewed
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[Journal Article] Comparative expression analysis of the H3K27 demethylases, JMJD3 and UTX, with the H3K27 methylase, EZH2, in Xenopus2012
Author(s)
Kawaguchi, A., Ochi, H., Sudou, N. and Ogino, H
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Journal Title
Int. J. Dev. Biol
Volume: 56
Pages: 295-300
Peer Reviewed
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[Journal Article] onserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR2010
Author(s)
Sato, S., Ikeda, K., Shioi, G., Ochi, H., Ogino, H., Yajima, H., Kawakami, K
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Journal Title
C. Dev. Biol
Volume: 344
Pages: 158-171
Peer Reviewed
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[Journal Article] Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm2010
Author(s)
Kurokawa, D., Ohmura, T., Ogino, H., Takeuchi, M., Inoue, A., Inoue, F., Suda, Y. and Aizawa, S
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Journal Title
Dev. Biol
Volume: 342
Pages: 110-120
Peer Reviewed
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