2011 Fiscal Year Final Research Report
Study on sensing of oxidative stress and redox cell signaling
| Project/Area Number |
21200069
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
Biological pharmacy
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| Research Institution | Tohoku Pharmaceutical University (2011)
Tohoku University (2009-2010) |
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Principal Investigator |
KUGE Shusuke 東北薬科大学, 薬学部, 教授 (50186376)
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| Co-Investigator(Renkei-kenkyūsha) |
IWAI Kenta 東北薬科大学, 薬学部, 助教 (50590006)
WATANABE Toshihiko 東北薬科大学, 薬学部, 講師 (20240509)
OGASAWARA Ayako 東北薬科大学, 薬学部, 助手 (70326726)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 酸化ストレス / レドックス / 感知 / 過酸化水素 / eIF2αリン酸化 / ペルオキシレドキシン |
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| Research Abstract |
Reactive oxygen species (ROS) is generated outside and inside the cells. An excess level of ROS results in damages on cells and cell death, which may cause various pathologic processes. By contrast, a lower level of ROS rather activates cell viability and growth. Cellular signaling involved in how the distinct effects of ROS is unsolved. Here, we identify peroxiredoxin proteins, which are known to be antioxidant protein, can act as sensor for ROS and have ability to regulate the glucose metabolism and the translational reprograming.
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[Journal Article] HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells.2012
Author(s)
Kubota N, Inayoshi Y, Satoh N. Fukuda T, Iwai K, Tomoda H, Kohara M, Kataoka K, Shimamoto A, Furuichi Y, Nomoto A, Naganuma A, Kuge S
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Journal Title
FEBS Letters
Volume: (in press)
DOI
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