インテリジェント人工核酸を搭載したナノＤＤＳによる革新的分子標的治療薬の研究

2013 Fiscal Year Annual Research Report

• Project/Area Number: 21229002
• Research Institution: Kyushu University
• Principal Investigator: 佐々木 茂貴 九州大学, 薬学研究科(研究院), 教授 (10170672)
• Co-Investigator(Kenkyū-buntansha): 野村 政壽 九州大学, 大学病院, 講師 (30315080) ; 新藤 充 九州大学, 先導物質化学研究所, 教授 (40226345) ; 永次 史 東北大学, 多元物質科学研究所, 教授 (90208025) ; 兵藤 守 北海道大学, 薬学研究科(研究院), その他 (30548186)
• Project Period (FY): 2009-05-11 – 2014-03-31
• Keywords: 核酸医薬 / 薬物送達 / ナノメディスン / 2型糖尿病 / 疾患モデルマウス

Research Abstract

本研究では、遺伝子応答性インテリジェント人工核酸を搭載した臓器特異的ナノDDSを合成し、疾患モデル動物での機能検証を経て、疾患関連mRNAおよびmiRNAを標的とするナノ分子標的治療薬の創製を目指した。本年度の研究実績を下記に記載した。
佐々木グループは昨年度までに、金属イオンとの相互作用によって高い反応性が誘起される転移官能基を開発した。本年度はこの転移反応を解析し、反応加速が金属錯体形成によるプローブと標的鎖の近接によることを明らかにした。兵藤（原島）グループとの共同でミトコンドリア病因遺伝子tRNALeu(UUR)を標的にした官能基転移核酸を設計し、ニッケルイオンを添加しない条件で標的シトシン修飾法を確立した。mRNAに対する官能基転移反応による塩基修飾の翻訳によるタンパク質発現への効果を詳細に検討するためのモデル発現系を構築した。新規ピリジン型修飾mRNAは逆転写反応の速度を低下させるものの、全長の転写物が得られた。永次グループはビニルスルフィドを含むプリン誘導体を新たに合成し、塩化ニッケル共存下酸化反応により活性化されシトシンと付加体を生成することを見出した。新藤グループは各種のボンクレキン酸誘導体および単純化化合物を検討し、高活性なアポ トーシス阻害物質を開発した。本年度は新しいトリカルボン酸体の合成法を確立した。野村グループは兵藤（原島）グループと共同で肝細胞特異的Drp1 cDNA 肝臓への遺伝子導入を検討し、ハイドロダイナミクス法によりマーカー遺伝子の発現を確認した。兵藤（原島）グループはこれまで、ミトコンドリア移行性素子MTSを用いることにより移行能を飛躍的に向上させたMITO-　Porterを構築し、mtDNAの存在するマトリクス領域へ送達可能である事を示した。オリゴ核酸のMITO-Porterへのパッケージング技術も確立し、これまでオリゴ核酸の輸送が困難だった膵β細胞(MIN6)に効果的に輸送できるシステムを確立した。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] 2,6-Diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine(2-amino-Adap) for recognition of 8-oxo-dG in DNA (2014)
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• [Journal Article] Synthesis of 8-halogenated-7-deaza-2'-deoxyguanosine as an8-oxo-2'-deoxyguanosine analogue and evaluation of its base pairing properties (2014)
  • Author(s): Yizhen Y., Taniguchi Y. and Sasaki S.
  • Journal Title: Tetrahedron Volume: 70(11) Pages: 2040-2047
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• [Journal Article] Identification of the5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highlyselective PDE4B inhibitors Bioorg (2014)
  • Author(s): Goto T., Shiina A., Murata T., Tomii M., YamazakiT., Yoshida K., Yoshino T., Suzuki O., Sogawa Y., Mizukami K., Takagi N.,Yoshitomi T., Etori M., Tsuchida H., Mikkaichi T., Nakao N., Takahashi M., Takahashi H, Sasaki S.
  • Journal Title: Med. Chem. Lett. Volume: 24(3) Pages: 893-899
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• [Journal Article] Development of Crosslinking Reactions to RNA Triggered by Oxidation (2014)
  • Author(s): Kusano S., Haruyama T., Ishiyama S., Hagihara S. and Nagatsugi F.
  • Journal Title: Chem.Commun, Volume: 50 Pages: 3951-3954
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• [Journal Article] Expression of glucagon-like peptide I receptor and its effects on biological behavior in pancreatic neuroendocrine tumors (2014)
  • Author(s): Cases AI, Ohtsuka T, Fujino M, Kozono S, Zhao M, Ohuchida K, Aishima S, Nomura M, Mizumoto K, Tanaka M
  • Journal Title: Pancreas Volume: 43 Pages: 1-6
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• [Journal Article] Smad2 disruption in mouse pancreatic b cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity (2014)
  • Author(s): Nomura M, Hei-lay Z, Wang L, Morinaga H, Takayanagi R, Teramoto N
  • Journal Title: Diabetologia Volume: 57 Pages: 157-166
• [Journal Article] MALDI Efficiency of Metabolites Quantitatively Associated with their Structural Properties: A QSPR Approach (2014)
  • Author(s): Daichi Yukihira, Daisuke Miura*, Yoshinori Fujimura, Yoshikatsu Umemura, Shinichi Yamaguchi, Shinji Funatsu, Makoto Yamazaki, Tetsuya Ohta, Hiroaki Inoue, Mitsuru Shindo, Hiroyuki Wariishi
  • Journal Title: Journal of The American Society for Mass Spectrometry Volume: 25 Pages: 1-5
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• [Journal Article] Xanthocidin Derivatives As Topoisomerase IIα Enzymatic Inhibitors (2014)
  • Author(s): Shuso TAKEDA, Kentaro YAJI, Kenji MATSUMOTO, Toshiaki AMAMOTO, Mitsuru SHINDO, and Hironori ARAMAKI
  • Journal Title: Biol. Pharm. Bull. Volume: 37 Pages: 331-334
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• [Journal Article] Generation of Ynolates via Reductive Lithiation Using Flow Microreactors (2014)
  • Author(s): Satoshi Umezu, Yoshiya Yoshiiwa, Manabu Tokeshi, Mitsuru Shindo
  • Journal Title: Tetrahedron Lett. Volume: 55 Pages: 1822-1825
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• [Journal Article] Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes (2014)
  • Author(s): Hayashi Y, Suemitsu E, Kajimoto K, Sato Y, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Kaji N, Baba Y, Harashima H.
  • Journal Title: Mol. Ther. Nucleic Acids. (nature publishing group) Volume: 3 Pages: e154
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• [Journal Article] RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system (2014)
  • Author(s): Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Ohga N, Hida K, Harashima H.
  • Journal Title: J. Control. Release (Elsevier) Volume: 173 Pages: 110-8
  • DOI: doi: 10.1016/j.jconrel.2013.10.003
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• [Journal Article] 4-Vinyl-Substituted Pyrimidine Nucleosides Exhibit the Efficient and SelectiveFormation of Interstrand Cross-Links with RNA and duplex DNA (2013)
  • Author(s): Nishimoto, A., Jitsuzaki, D., Onizuka, K., Taniguchi, Y., Nagatsugi, F. and Sasaki, S
  • Journal Title: Nucleic Acids Res Volume: 41 Pages: 6774-6781
  • DOI: 10.1093/nar/gkt197
• [Journal Article] The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway (2013)
  • Author(s): Kamakura S., Nomura M., Hayase J., Iwakiri Y., Nishikimi A., Fukui Y., Takayanagi R., Sumimoto H.
  • Journal Title: Dev Cell Volume: 26 Pages: 292-302
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• [Journal Article] Synthesis of 1'-phenyl-2-OMe ribose analogues connecting the thymine base at the 1' position through a flexible linker for the formation of a stable anti-parallele triplex DNA (2013)
  • Author(s): Taniguchi Y., Okamura H., Fujino N., Sasaki S.
  • Journal Title: Tetrahedron Volume: 69(2) Pages: 600-606
  • DOI: DOI: 10.1016/j.tet.2012.11.016
  • Peer Reviewed
• [Journal Article] Synthesis of the Oligoribonucleotides Incorporating 8-Oxo-guanosine and Evaluation of their Base Pairing Properties (2013)
  • Author(s): Koga Y., Taniguchi Y and Sasaki S.
  • Journal Title: Nucleosides, Nucleotides and Nucleic Acids Volume: 32(3) Pages: 124-136
  • DOI: DOI: 10.1080/15257770.2013.767461
  • Peer Reviewed
• [Journal Article] Identification of the fused bicyclic4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. (2013)
  • Author(s): Goto T., Shiina A., Yoshino T., Mizukami K.,Hirahara K., Suzuki O., Sogawa Y., Takahashi T., Mikkaichi T., Nakao N., TakahashiM., Hasegawa M. and Sasaki S.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 23(11) Pages: 3325-3328
  • DOI: DOI: http://dx.doi.org/10.1016/j.bmcl.2013.03.104
  • Peer Reviewed
• [Journal Article] N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits a selective recognition of a CG interrupting site for the formation of anti-parallel triplexes (2013)
  • Author(s): Okamura H, Taniguchi Y and Sasaki S.
  • Journal Title: Org. Biomol. Chem. Volume: 11 Pages: 3918-3924
  • DOI: DOI: 10.1039/C3OB40472B
  • Peer Reviewed
• [Journal Article] Enantioselective Binding of Chiral 1,14-Dimethyl[5]Helicene-spermine Ligands with B- and Z-DNA (2013)
  • Author(s): Tsuji G,, Kawakami K and Sasaki S.
  • Journal Title: Bioorg. Med. Chem. Volume: 21 (19) Pages: 6063-6068
  • DOI: DOI: http://dx.doi.org/10.1016/j.bmc.2013.07.022
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidinederivatives as novel and potent PDE4 inhibitors (2013)
  • Author(s): Goto T., Shiina A., Yoshino T., Mizukami K.,Hirahara K., Suzuki O., Sogawa Y., Takahashi T., Mikkaichi T., Nakao N.,Takahashi M., Hasegawa M. and Sasaki S.
  • Journal Title: Bioorg. Med. Chem. Volume: 21 (22) Pages: 7025-7037
  • DOI: DOI: http://dx.doi.org/10.1016/j.bmc.2013.09.013
  • Peer Reviewed
• [Journal Article] B-Z Transition of (dA-T)n Duplex Induced by Spermine Porphyrin-Conjugate via anIntermediate DNA Conformation (2013)
  • Author(s): Sasaki H. and Sasaki S.
  • Journal Title: Chem. Comm. Volume: 49(79) Pages: 9024-9026
  • DOI: DOI: 10.1039/C3CC45213A
  • Peer Reviewed
• [Journal Article] Synthesis of 8-oxoguanosine phosphoramidite and its incorporation into oligoribonucleotides (2013)
  • Author(s): Taniguchi Y., Koga Y., Shigeki S.
  • Journal Title: Current Protocols in Nucleic Acid Chemistry Volume: UNIT4.58 Pages: 4.58.1-4.58.10
  • DOI: DOI:10.1002/0471142700.nc0458s56
  • Peer Reviewed
• [Journal Article] The Crosslink Formation of 2 '-OMe Oligonucleotide Containing 2-Amino-6-vinylpurine Protects mRNA from miRNA-Mediated Silencing (2013)
  • Author(s): Hagihara, S., Lin, W.C., Kusano, S., Chao, X.G., Hori, T., Imoto, S. and Nagatsugi, F.
  • Journal Title: Chembiochem Volume: 14 Pages: 1427-1429
  • DOI: DOI:10.1002/cbic.201300382
  • Peer Reviewed
• [Journal Article] Synthesis of peptide-conjugated light-driven molecular motors and evaluation of their DNA-binding properties (2013)
  • Author(s): Nagatsugi, F., Takahashi, Y., Kobayashi, M., Kuwahara, S., Kusano, S., Chikuni, T., Hagihara, S. and Harada, N.
  • Journal Title: Molecular Biosystems Volume: 9 Pages: 969-973
  • DOI: DOI:10.1039/c2mb25520k
  • Peer Reviewed
• [Journal Article] Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance (2013)
  • Author(s): Matsuura H, Ichiki T, Inoue E, Nomura M, Miyazaki R, Hashimoto T, Ikeda J, Takayanagi R. Fong GH, Sunagawa K.
  • Journal Title: Circulation Volume: 127 Pages: 2078-87
  • DOI: doi: 10.1161/CIRCULATIONAHA. 113.001742
  • Peer Reviewed
• [Journal Article] Activin stimulates CYP19A gene expression in the human ovarian granulosa cell like KGN cells via the Smad2 signaling pathway (2013)
  • Author(s): Nomura M, Sakamoto R, Morinaga H, Wang L, Mukasa C, Takayanagi R
  • Journal Title: Biochem Biophys Res Commun Volume: 436 Pages: 443-448
  • Peer Reviewed
• [Journal Article] Smad2/3 and IRF4 play a cooperative role in interleukin-9-producing T cell induction (2013)
  • Author(s): Tamiya T, Ichiyama K, Kotani H, Fukaya T, Sekiya T, Shichita T, Honma K, Yui K, Matsuyama T, Nakao T, Fukuyama S, Inoue H, Nomura M, Yoshimura A
  • Journal Title: J Immunology Volume: 191 Pages: 2360-71
  • DOI: doi: 10.4049/jimmunol.1301276
  • Peer Reviewed
• [Journal Article] Roles for corticotropin-releasing factor receptor type 1 in energy homeostasis in mice (2013)
  • Author(s): Sakamoto R, Matsubara E, Nomura M, Wang L, Matsubara E, Kawahara Y, Yanase T, Nawata H, Takayanagi R
  • Journal Title: Metabolism Volume: 62 Pages: 1739-48
  • DOI: doi: 10.1016/j.metabol.2013.08.005
  • Peer Reviewed
• [Journal Article] (-)-Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells (2013)
  • Author(s): Shuso Takeda, Hajime Nishimura, Kuniyoshi Koyachi, Kenji Matsumoto, Kazutaka Yoshida, Yoshiko Okamoto, Toshiaki Amamoto, Mitsuru Shindo, Hironori Aramaki
  • Journal Title: The Journal of Toxicological Sciences Volume: 38 Pages: 547-557
  • Peer Reviewed
• [Journal Article] Root-specific induction of early auxin-responsive genes in Arabidopsis thaliana by cis-cinnamic acid (2013)
  • Author(s): Naoya Wasano, Mami Sugano, Keisuke Nishikawa, Katsuhiro Okuda, Mitsuru Shindo, Hiroshi Abe, So-Young Park, Syuntaro Hiradate, Tsunashi Kamo*, Yoshiharu Fujii
  • Journal Title: Plant Biotechnology, Volume: 30 Pages: 465-471
  • DOI: DOI: 10.5511/plantbiotechnology.13.0718a
  • Peer Reviewed
• [Journal Article] Substituent effects of cis-cinnamic acid analogues as plant growh inhibitors (2013)
  • Author(s): Keisuke Nishikawa, Hiroshi Fukuda, Masato Abe, Kazunari Nakanishi, Tomoya Taniguchi, Takashi Nomura, Chihiro Yamaguchi, Syuntaro Hiradate, Yoshiharu Fujii, Katsuhiro Okuda, Mitsuru Shindo
  • Journal Title: Phytochemistry Volume: 96 Pages: 132-147
  • DOI: doi.org/10.1016/j.phytochem.2013.08.013
  • Peer Reviewed
• [Journal Article] Design and Synthesis of Conformationally Constrained Analogues of cis-Cinnamic Acid and Evaluation of Their Plant Growth Inhibitory Activity (2013)
  • Author(s): Keisuke Nishikawa, Hiroshi Fukuda, Masato Abe, Kazunari Nakanishi, Yuta Tazawa, Chihiro Yamaguchi, Syuntaro Hiradate, Yoshiharu Fujii, Katsuhiro Okuda, Mitsuru Shindo
  • Journal Title: Phytochemistry Volume: 96 Pages: 223-234
  • DOI: doi.org/10.1016/j.phytochem.2013.10.001
  • Peer Reviewed
• [Journal Article] α-Substituent Effect on Olefination of Ester Carbonyl Groups with Ynolates (2013)
  • Author(s): Satoshi Umezu, Mitsuru Shindo
  • Journal Title: Tetrahedron Lett. Volume: 54 Pages: 6871-6873
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• [Journal Article] Synthesis of Xanthanolides Including New Acylations and Their Synthetic Applications (2013)
  • Author(s): Mitsuru Shindo, Kenji Matsumoto
  • Journal Title: J. Syn. Org. Chem. Japan Volume: 71 Pages: 1152-1162
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• [Journal Article] Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system (2013)
  • Author(s): Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Harashima H.
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  • DOI: doi: 10.1038/mt.2013.57
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• [Journal Article] A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication (2013)
  • Author(s): Hossen MN, Kajimoto K, Akita H, Hyodo M, Harashima H.
  • Journal Title: J. Control. Release Volume: 171 Pages: 104-12
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• [Journal Article] Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide (2013)
  • Author(s): Kawamura E, Yamada Y, Yasuzaki Y, Hyodo M, Harashima H.
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• [Journal Article] Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter (2013)
  • Author(s): Kawamura E, Yamada Y, Harashima H.
  • Journal Title: Mitochondrion Volume: 13 Pages: 610-4
  • Peer Reviewed
• [Journal Article] Investigation of siRNA nanoparticle formation using mono-cationic detergents and its use in gene silencing in human HeLa cells (2013)
  • Author(s): Yamada Y, Suzuki R, Harashima H.
  • Journal Title: Cancers (MDPI) Volume: 5 Pages: 1413-25
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• [Journal Article] A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence (2013)
  • Author(s): Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, Harashima H.
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  • Peer Reviewed
• [Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells (2013)
  • Author(s): Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
  • Journal Title: J Pharm Sci. (Wiley) Volume: 102 Pages: 1008-15
  • DOI: doi/10.1002/jps
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• [Journal Article] Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier. (2013)
  • Author(s): Yamada Y, Harashima H.
  • Journal Title: Mitochondrion. (Elsevier) Volume: 13 Pages: 526-32
  • DOI: doi: 10.1016/j.mito.2012.09.001
  • Peer Reviewed
• [Journal Article] An approach to transgene expression in liver endothelial cells using a liposome-based gene vector coated with hyaluronic acid (2013)
  • Author(s): Yamada Y, Hashida M, Hayashi Y, Tabata M, Hyodo M, Ara MN, Ohga N, Hida K, Harashima H.
  • Journal Title: J Pharm Sci. (Wiley) Volume: 102 Pages: 3119-27
  • DOI: doi/10.1002/jps
  • Peer Reviewed
• [Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine (2013)
  • Author(s): Toriyabe N, Hayashi Y, Harashima H.
  • Journal Title: Biomaterials. (Elsevier) Volume: 34 Pages: 1337-43
  • DOI: doi: 10.1016/j.biomaterials.2012.10.043
  • Peer Reviewed
• [Presentation] 遺伝子改変マウスを用いた消化管味覚生理研究の最前線 (2014)
  • Author(s): 野村政壽
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 水前寺青年会館ホール, 熊本
  • Year and Date: 20140328-20140328
• [Presentation] ミトコンドリア標的型ナノデバイス”MITO-Porter”の創製 (2014)
  • Author(s): 山田勇磨
  • Organizer: 日本薬学会 第134年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140328-20140328
  • Invited
• [Presentation] 架橋反応性核酸塩基を導入したペプチド核酸の合成と評価 (2014)
  • Author(s): 秋澤 拓也、石澤 悠樹、永次 史
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
  • Year and Date: 20140327-20140330
• [Presentation] グアニン類縁体に対する架橋形成ピリミジン誘導体の反応性 (2014)
  • Author(s): 石山 翔午、草野 修平、永次 史
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
  • Year and Date: 20140327-20140330
• [Presentation] 細胞内遺伝子発現制御を目指した酸化応答型架橋反応性核酸の開発 (2014)
  • Author(s): 春山拓哉・草野修平・永次 史
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
  • Year and Date: 20140327-20140330
• [Presentation] 疎水空間を有する2本鎖DNAに対する化学修飾法の開発 (2014)
  • Author(s): 佐藤 憲大・辻 厳一郎・茂木 琢真・永次 史
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
  • Year and Date: 20140327-20140330
• [Presentation] CG塩基対を安定かつ選択的に認識可能なN²ｰ修飾イソシチジン誘導体の合成と３本鎖形成能の評価 (2014)
  • Author(s): 岡村 秀紀, 谷口 陽祐, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] 金属錯体形成を利用したRNA部位特異的化学修飾反応の開発と反応機構解析 (2014)
  • Author(s): 實崎 大地, 鬼塚 和光, 西本 篤史, 谷口 陽祐, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] クロスリンク核酸を導入したDNA i-motifの安定性の検討 (2014)
  • Author(s): 朴 海順, 秋島 広佑, 實崎 大地, 谷口 陽祐, 佐々木 茂貴, Brazier JOHN
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] 金属応答性ピリミジン型機能性人工核酸を用いた高効率アデニン特異的RNA修飾反応の開発 (2014)
  • Author(s): 大城 郁也, 實崎 大地, 西本 篤史, 鬼塚 和光, 谷口 陽祐, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] CpGアイランド特異的に結合する人工核酸の開発 (2014)
  • Author(s): 松枝 望, 谷口 陽祐, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] RNA2'-OH部位特異的な修飾反応の開発 (2014)
  • Author(s): 羽田野 友里恵, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] 8-oxodG選択性向上を目指したAdap誘導体の開発 (2014)
  • Author(s): 菊川 誉也, 谷口 陽祐, 深堀 慶太郎, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] Synthesis and evaluation of 8-halogenated-7-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguanosine analogues (2014)
  • Author(s): 尹 貽貞, 谷口 陽祐, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] 金属錯体形成を基本とした多協同的DNA結合性低分子の開発 (2014)
  • Author(s): 村瀬 裕貴, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] ヘキスト誘導体による二本鎖DNA上に存在する繰り返し配列への協奏的集積の評価 (2014)
  • Author(s): 江田 裕則, John BRAZIER, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] [5]ヘリセンリガンドのキラル平衡及びDNAのB-Z遷移に基づく動的な不斉誘起の検討 (2014)
  • Author(s): 川良 健祐, 辻 厳一郎, 佐々木 茂貴
  • Organizer: 日本薬学会第１３４回年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] 化学反応性オリゴDNAを用いたRNA標的擬ロタキサン形成法の開発 (2014)
  • Author(s): 鬼塚和光、伊藤嘉浩、阿部 洋、永次 史
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学
  • Year and Date: 20140327-20140330
• [Presentation] MITO-Porter, a mitochondrial drug delivery system toward innovative medicine and therapy (2014)
  • Author(s): Y. Yamada
  • Organizer: 2nd CRED Symposium for Academic Drug Discovery
  • Place of Presentation: Sapporo
  • Year and Date: 20140224-20140224
  • Invited
• [Presentation] MITO-Porter, Liposome-Based Nano Device for Mitochondrial Control (2014)
  • Author(s): Y. Yamada
  • Organizer: iCeMS-RIKEN Joint Symposium on Mesoscopic Chemical Biology- Integrated Chemical-Physical Systems Towards Cell Control-
  • Place of Presentation: Kyoto
  • Year and Date: 20140207-20140207
  • Invited
• [Presentation] Development of the Strategy for the Selective Chemical Modification in Hydrophobic Pockets (2014)
  • Author(s): F. Nagatsugi, G. Tsuji, S.Norihiro
  • Organizer: Asian Chemical Biology Initiative 2014
  • Place of Presentation: Manila Meeting Manila Hotel
  • Year and Date: 20140124-20140124
  • Invited
• [Presentation] アシル化を鍵反応とする有機合成 (2014)
  • Author(s): 新藤充
  • Organizer: 帝京大学薬学部講演会
  • Place of Presentation: 東京
  • Year and Date: 20140124-20140124
  • Invited
• [Presentation] A New Therapeutic Approach Based on Genome-Targeting Chemistry (2014)
  • Author(s): Shigeki Sasaki
  • Organizer: Proceedings of the 11th International Symposium
  • Place of Presentation: Korea
  • Year and Date: 20140117-20140117
  • Invited
• [Presentation] 遺伝子発現の化学的制御を目指した機能性分子の創製とその機能性評価 (2013)
  • Author(s): 永次 史
  • Organizer: 第３回 慶応義塾大学 戦略的研究基盤形成支援事業シンポジウム
  • Place of Presentation: 慶応義塾大学日吉キャンパス
  • Year and Date: 20131221-20131221
  • Invited
• [Presentation] Investigation of tumor endothelial cell targeting aptamer and its application for drug delivery. (2013)
  • Author(s): M. Hyodo
  • Organizer: The 16th Hokkaido University-Seoul National University Joint Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20131213-20131213
  • Invited
• [Presentation] ピリミジン型機能性人工核酸を用いた金属カチオン応答性アデニン特異的RNA修飾法の開発 (2013)
  • Author(s): 大城郁也、實崎大地、西本篤史、鬼塚和光、谷口陽祐、佐々木茂貴
  • Organizer: 第30回日本薬学会九州支部大会
  • Place of Presentation: 長崎（長崎国際大学）
  • Year and Date: 20131207-20131208
• [Presentation] 8-oxodGに対する塩基選択性の向上を目指したAdap誘導体の開発 (2013)
  • Author(s): 菊川誉也、谷口陽祐、深堀慶太郎、佐々木茂貴
  • Organizer: 第30回日本薬学会九州支部大会
  • Place of Presentation: 長崎（長崎国際大学）
  • Year and Date: 20131207-20131208
• [Presentation] CpGアイランドを標的とした人工核酸の開発 (2013)
  • Author(s): 松枝望、谷口陽祐、佐々木茂貴
  • Organizer: 第30回日本薬学会九州支部大会
  • Place of Presentation: 長崎（長崎国際大学）
  • Year and Date: 20131207-20131208
• [Presentation] 2'位メトキシピリミジン型クロスリンク核酸の開発と評価 (2013)
  • Author(s): 秋島広佑、西本篤史、實崎大地、谷口陽祐、永次史、佐々木茂貴
  • Organizer: 第30回日本薬学会九州支部大会
  • Place of Presentation: 長崎（長崎国際大学）
  • Year and Date: 20131207-20131208
• [Presentation] Total Synthesis of Stemonamine (2013)
  • Author(s): 新藤充
  • Organizer: ISIS-8
  • Place of Presentation: 奈良
  • Year and Date: 20131130-20131130
  • Invited
• [Presentation] 金属錯体形成によりRNAを部位特異的に化学修飾する機能性人工核酸の開発 (2013)
  • Author(s): 實崎大地 、鬼塚和光 、西本篤史 、谷口陽祐 、佐々木茂貴
  • Organizer: 第２３回アンチセンスシンポジウム
  • Place of Presentation: 徳島（徳島大学大塚講堂）
  • Year and Date: 20131128-20131129
• [Presentation] エクソン-イントロン接合部に重複したマイクロ RNA の発現 (2013)
  • Author(s): 柴田篤志 、佐々木茂貴
  • Organizer: 第２３回アンチセンスシンポジウム
  • Place of Presentation: 徳島（徳島大学大塚講堂）
  • Year and Date: 20131128-20131129
• [Presentation] 架橋反応性核酸を用いた細胞内における遺伝子発現制御に向けた検討 (2013)
  • Author(s): 永次 史、萩原伸也、草野修平
  • Organizer: 第２３回アンチセンスシンポジウム
  • Place of Presentation: 徳島（徳島大学大塚講堂）
  • Year and Date: 20131128-20131129
• [Presentation] 架橋反応性ペプチド核酸の合成と反応性検討 (2013)
  • Author(s): 秋澤 拓也、石澤 悠樹、永次 史
  • Organizer: 第２３回アンチセンスシンポジウム
  • Place of Presentation: 徳島（徳島大学大塚講堂）
  • Year and Date: 20131128-20131129
• [Presentation] An Efficient Reaction for Pinpoint Modification of RNA Promoted by Proximity Effect via Transition Metal Complex (2013)
  • Author(s): Shigeki Sasaki, Daichi Jitsuzaki, Onizuka Kazumitsu, Nishimoto Atsushi, Shibata Atsushi, Oshiro Ikuya, Yosuke Taniguchi
  • Organizer: ICCEPOCA-8/NICCEOCA-4
  • Place of Presentation: Osaka
  • Year and Date: 20131125-20131128
• [Presentation] 次世代型核酸医薬を目指した架橋反応性核酸の開発 (2013)
  • Author(s): 永次 史
  • Organizer: 第7回次世代を担う医療薬科学シンポジウム
  • Place of Presentation: 片平さくらホール 仙台
  • Year and Date: 20131123-20131124
  • Invited
• [Presentation] N²-Modified Isocytidine Derivatives for Selective CG Base Pair Recognition in the Triplex DNA (2013)
  • Author(s): Hedenori Okamura, Yosuke Taniguchi, Shigeki Sasaki
  • Organizer: 3rd ACP Junior Symposium
  • Place of Presentation: Chiba
  • Year and Date: 20131122-20131125
• [Presentation] 脱塩基部位を特異的に切断する核酸- ポリアミン結合体の特性 (2013)
  • Author(s): 阿部由紀子，山口莉慧，佐々木茂貴
  • Organizer: 第３１回メディシナルケミストリーシンポジウム
  • Place of Presentation: 広島（広島市アステールプラザ）
  • Year and Date: 20131120-20131122
• [Presentation] An antiproliferative eff ect by targeting oncogene with antigene oligonucleotides containing WNA-βT in an antiparallel triplex formation (2013)
  • Author(s): Yosuke Taniguchi, Shigeki Sasaki
  • Organizer: 第４０回国際核酸化学シンポジウム
  • Place of Presentation: Kanagawa University, Japan
  • Year and Date: 20131113-20131115
• [Presentation] Sequence specific adenosine modification of RNA by functionality-transfer ODN accelerated by metal cations (2013)
  • Author(s): Ikuya Oshiro, Daichi Jitsuzaki, Atsushi Nishimoto, Kazumitsu Onizuka, Yosuke Taniguchi, Shigeki Sasaki
  • Organizer: 第４０回国際核酸化学シンポジウム
  • Place of Presentation: Kanagawa University, Japan
  • Year and Date: 20131113-20131115
• [Presentation] ODN containing functionalized thioguanosine: Useful tools for selective guanosine RNA targeting (2013)
  • Author(s): Jan Barta, Daichi Jitsuzaki, Yosuke Taniguchi, Shigeki Sasaki
  • Organizer: 第４０回国際核酸化学シンポジウム
  • Place of Presentation: Kanagawa University, Japan
  • Year and Date: 20131113-20131115
• [Presentation] Synthesis and evaluation of novel Hoechst derivatives for cooperative binding to repeating DNA sequences (2013)
  • Author(s): Hironori Koda, John Brazier, Shigeki Sasaki
  • Organizer: 第４０回国際核酸化学シンポジウム
  • Place of Presentation: 神奈川
  • Year and Date: 20131113-20131115
• [Presentation] Development of Molecular Probe for the Selective Modification in an Abasic Site (2013)
  • Author(s): Gen-ichiro Tsuji, Norihiro Sato, Takuma Moki, Fumi Nagatsugi
  • Organizer: 第４０回国際核酸化学シンポジウム
  • Place of Presentation: Kanagawa University, Japan
  • Year and Date: 20131113-20131115
• [Presentation] Development of the Oxidation Induced Crosslink Reaction (2013)
  • Author(s): Shuhei Kusano, Takuya Haruyama, Nao Iwamoto, Shinya Hagihara, Fumi Nagatsugi
  • Organizer: 第４０回国際核酸化学シンポジウム
  • Place of Presentation: Kanagawa University, Japan
  • Year and Date: 20131113-20131115
• [Presentation] イノラートの反応と展開 (2013)
  • Author(s): 新藤充
  • Organizer: 第3回大塚有機合成シンポジウム
  • Place of Presentation: 徳島
  • Year and Date: 20131108-20131108
  • Invited
• [Presentation] 二種の金属錯体を形成部位をもつアントラセノン誘導体の合成とDNAリピート配列への多協同的結合の検討 (2013)
  • Author(s): 村瀬裕貴、佐々木茂貴
  • Organizer: 第３９回反応と合成の進歩シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 20131105-20131106
• [Presentation] 金属応答性ピリミジン型機能性人工核酸を用いたアデニン特異的RNA修飾法の開発 (2013)
  • Author(s): 大城郁也、實崎大地、西本篤史、鬼塚和光、谷口陽祐、佐々木茂貴
  • Organizer: 第３９回反応と合成の進歩シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 20131105-20131106
• [Presentation] グアニンおよび8-オキソグアニンに対する架橋形成ピリミジン誘導体の反応性 (2013)
  • Author(s): 石山 翔午，草野 修平，永次 史
  • Organizer: 第３９回反応と合成の進歩シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 20131105-20131106
• [Presentation] 塩基欠損部位を有する２本鎖DNAに対する化学的修飾法の開発 (2013)
  • Author(s): 辻厳一郎、佐藤憲大、茂木琢真、永次 史
  • Organizer: 第３９回反応と合成の進歩シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 20131105-20131106
• [Presentation] 架橋反応性核酸を用いたIn Cell Chemistryへの展開(Selected Oral) (2013)
  • Author(s): 永次 史、萩原伸也、草野修平、春山拓哉
  • Organizer: 第３９回反応と合成の進歩シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 20131105-20131106
• [Presentation] Development of the New Strategy for Selective Reactions to DNA in an Abasic site (2013)
  • Author(s): Fumi Nagatsugi
  • Organizer: The 2nd International Symposium on Chemical Biology of Natural Products:Target ID and Regulation of Bioactivity
  • Place of Presentation: PACIFICO YOKOHAMA, Japan
  • Year and Date: 20131028-20131029
• [Presentation] Regulation of the Gene Expression by the Use of Reactive Oligonucleotides (2013)
  • Author(s): Fumi Nagatsugi
  • Organizer: Technologies for Medical Diagnostic and Therapy Symposium
  • Place of Presentation: academia sinica, Taiwan
  • Year and Date: 20131022-20131023
  • Invited
• [Presentation] CG塩基対を選択的に認識するN2-修飾イソシチジン誘導体の合成と3本鎖形成能の評価 (2013)
  • Author(s): 岡村秀紀、谷口陽祐、佐々木茂貴
  • Organizer: 第４３回複素環化学討論会
  • Place of Presentation: 岐阜
  • Year and Date: 20131017-20131019
• [Presentation] DNAのB-Z平衡と[5]ヘリセンリガンドの不斉平衡に基づく動的不斉誘起の検討 (2013)
  • Author(s): 川良健祐、辻厳一郎、佐々木茂貴
  • Organizer: 第４３回複素環化学討論会
  • Place of Presentation: 岐阜
  • Year and Date: 20131017-20131019
• [Presentation] Synthesesand Evaluation of Anti-parallel Triplex Formation of 1’-Phenyl-2’-ThymineNucleoside Analogues for the Application to the Antigene Strategy (2013)
  • Author(s): Yosuke Taniguchi,Akira Tomizaki, Hidenori Okamura, Syohei Misumi, Tomoko Takaki, Naoto Ishibashi and Shigeki Sasaki
  • Organizer: ＡＩＭＥＣＳ２０１３
  • Place of Presentation: 台湾
  • Year and Date: 20131015-20131018
• [Presentation] アレロパシーのケミカルバイオロジー研究 (2013)
  • Author(s): 新藤充
  • Organizer: 東北大学大学院研究科
  • Place of Presentation: 東北大学
  • Year and Date: 20131007-20131007
  • Invited
• [Presentation] T-Viny1 Derivative as an 4 Efficient and Selective Cross-Linking Agent for RNA and duplex DNA (2013)
  • Author(s): Shigeki Sasaki, Nishimoto A., Jitsuzaki D., Onizuka K., Yosuke Taniguchi, Nahatsugi F.
  • Organizer: 9th Annual Meeting of the OLIGONYCLEOTIDE Therapeutics Society
  • Place of Presentation: Napoli, Italia
  • Year and Date: 20131006-20131008
• [Presentation] Effective Chemical Strategy for Regulation of Gene Expression using Cross-linking Reactions (2013)
  • Author(s): Fumi Nagatsugi, Shinya Hagihara, Shuhei Kusano, Takuya Akisawa
  • Organizer: 9th Annual Meeting of the OLIGONYCLEOTIDE Therapeutics Society
  • Place of Presentation: Napoli, Italia
  • Year and Date: 20131006-20131008
• [Presentation] Development of the molecular probes to achieve the selective chemical modification in an abasic site (2013)
  • Author(s): Norihiro Sato, Takuma Moki, Shinya Hagihara, Fumi Nagatsugi
  • Organizer: International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
  • Place of Presentation: Sendai, Japan
  • Year and Date: 20130928-20130930
• [Presentation] Synthesis of Peptide Nucleic Acid (PNA) containing Cross-linking Agent (2013)
  • Author(s): Akisawa Takuya, Ishizawa Yuki, Nagatsugi Fumi
  • Organizer: International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
  • Place of Presentation: Sendai, Japan
  • Year and Date: 20130928-20130930
• [Presentation] Development of the cross-link forming pyrimidine derivative (2013)
  • Author(s): Shuhei Kusano, Shogo Ishiyama, Shinya Hagihara, and Fumi Nagatsugi
  • Organizer: International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
  • Place of Presentation: Sendai, Japan
  • Year and Date: 20130928-20130930
• [Presentation] 二種の金属錯体形成部位をもつ分子によるDNAリピート配列への協同的結合の検討 (2013)
  • Author(s): 村瀬裕貴、佐々木茂貴
  • Organizer: 第７回バイオ関連化学シンポジウム
  • Place of Presentation: 名古屋 名古屋大学
  • Year and Date: 20130927-20130929
• [Presentation] 繰り返し領域を含む二本鎖DNAに対して協奏的に集積する低分子化合物の合成および評価 (2013)
  • Author(s): 江田裕則、JohnBrazier、佐々木茂貴
  • Organizer: 第７回バイオ関連化学シンポジウム
  • Place of Presentation: 名古屋 名古屋大学
  • Year and Date: 20130927-20130929
• [Presentation] コンフォメーションを固定した新規架橋反応性核酸の開発 (2013)
  • Author(s): 井田裕太、萩原伸也、草野修平、永次 史
  • Organizer: 第７回バイオ関連化学シンポジウム
  • Place of Presentation: 名古屋 名古屋大学
  • Year and Date: 20130927-20130929
• [Presentation] 酸化反応をトリガーとする架橋反応の開発 (2013)
  • Author(s): 草野 修平、岩本 直生、萩原 伸也、永次 史
  • Organizer: 第７回バイオ関連化学シンポジウム
  • Place of Presentation: 名古屋 名古屋大学
  • Year and Date: 20130927-20130929
• [Presentation] 酸化反応をトリガーとする架橋反応性分子の開発 (2013)
  • Author(s): 草野 修平、岩本 直生、萩原 伸也、春山 拓哉、永次 史
  • Organizer: 第１回バイオ関連化学シンポジウム若手フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 20130926-20130926
• [Presentation] Reactions of Ynolates and Synthetic Applications (2013)
  • Author(s): M. Shindo
  • Organizer: 10th International Symposium on Carbanion Chemistry
  • Place of Presentation: Kyoto
  • Year and Date: 20130925-20130925
  • Invited
• [Presentation] Site-Specific Chemical Modification of RNA and Impact on its Function (2013)
  • Author(s): Shigeki Sasaki
  • Organizer: Asia 3 Roundtable of Nucleic Acids 2013, Japan
  • Place of Presentation: Portapia Hotel, Kobe
  • Year and Date: 20130830-20130901
• [Presentation] Design of the efficient cross-linking agent with the fixed conformation (2013)
  • Author(s): Yuta Ida, Shuhei Kusano, Shinya Hagihara, Fumi Nagatsugi
  • Organizer: Tohoku University Campus Asia Program Summer School 2013
  • Place of Presentation: Sendai, Japan
  • Year and Date: 20130828-20130830
• [Presentation] Functionality Transfer for the Pinpoint Selective Modefication of RNA Inducible Reactivity Mediated by Chelate Formation with Metal Cation (2013)
  • Author(s): Shigeki Sasaki, Yosuke Taniguchi, D. Jitsuzaki, K.Onizuka, A.Nishimoto, I.Oshiro, A.Shibata
  • Organizer: The 5th Asian Aeden Confernce
  • Place of Presentation: Nagoya City University
  • Year and Date: 20130805-20130806
• [Presentation] Development of the Effective Chemical Strategy for Regulation of Gene Expression (2013)
  • Author(s): Fumi Nagatsugi, Shinya Hagihara , Shuhei Kusano, Norihiro Sato
  • Organizer: The 5th Asian Aeden Confernce
  • Place of Presentation: Nagoya City University
  • Year and Date: 20130805-20130806
• [Presentation] An approach to mitochondrial genesilencing by the mitochondrial delivery of anti-sense RNA (2013)
  • Author(s): Y. Yamada, R. Furukawa, E. Kawamura, H. Harashima
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20130721-20130724
• [Presentation] Improvement of mitochondrial targeting activity of MITO-Porter using functional peptides (2013)
  • Author(s): E. Kawamura, Y. Yamada, H. Harashima
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20130721-20130724
• [Presentation] A new approach for innovative nanomedicine of type 2 diabetes in combination with DNA microarray and in vivo siRNA delivery (2013)
  • Author(s): Suemitsu E, Hayashi Y, Kajimoto K, Sato Y, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Harashima H,
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20130721-20130724
• [Presentation] Inhibition of the cell proliferation using triplex forming oligonucleotides containing a W-shaped Nucleoside analogues (2013)
  • Author(s): Yosuke Taniguchi and Shigeki Sasaki
  • Organizer: ＡＣＭＳ２０１３
  • Place of Presentation: 沖縄
  • Year and Date: 20130717-20130719
• [Presentation] N-(Guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits selective recognition of the CG inversion site for the formation of anti-parallel triplex DNA (2013)
  • Author(s): Hidenori Okamura, Yosuke Taniguchi, and Shigeki Sasaki
  • Organizer: ＡＣＭＳ２０１３
  • Place of Presentation: 沖縄
  • Year and Date: 20130717-20130719
• [Presentation] 遷移金属カチオンにより活性化する部位特異的RNA化学修飾反応の開発と反応機構の解析 (2013)
  • Author(s): 實崎大地、鬼塚和光、西本篤史、谷口陽祐、佐々木茂貴
  • Organizer: 第５０回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 20130706-20130706
• [Presentation] Design, synthesis, and properties of 8-halogenated-7-deaza-2’-deoxyguanosine as analogues of 8-oxo-2’-deoxyguanosine (2013)
  • Author(s): 尹貽貞、谷口陽祐、佐々木茂貴
  • Organizer: 第５０回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 20130706-20130706
• [Presentation] ＤＮＡ上の繰り返し配列に対して協奏的に自己集積する低分子化合物の開発 (2013)
  • Author(s): 江田裕則、John BRAZIER、佐々木茂貴
  • Organizer: 第５０回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 20130706-20130706
• [Presentation] CG 塩基対を選択的に認識可能なN- グアニジノエチルイソシチジンの合成と3 本鎖DNA 形成能の評価 (2013)
  • Author(s): 岡村秀紀、谷口陽祐、佐々木茂貴
  • Organizer: 第５０回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 20130706-20130706
• [Presentation] Mitochondrial dynamics in energy homeostasis (2013)
  • Author(s): Nomura M.
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Osaka International Convention Center, Osaka, Japan
  • Year and Date: 20130704-20130707
• [Presentation] ミトコンドリア標的型核酸ナノキャリアの開発および遺伝子治療への挑戦 (2013)
  • Author(s): 山田勇磨
  • Organizer: 第29回日本DDS学会
  • Place of Presentation: 京都
  • Year and Date: 20130704-20130705
  • Invited
• [Presentation] Development of the Effective Chemical Strategy for Regulation of Gene Expression (2013)
  • Author(s): Fumi Nagatsugi, Shinya Hagihara , Shuhei Kusano, Norihiro Sato
  • Organizer: Gordon Conference on nucleoside, nucleotide and oligonucleotide
  • Place of Presentation: Newport, U.S.A.
  • Year and Date: 20130630-20130706
• [Presentation] An efficient method for RNA modification with high sequence and base selectivity using non-natural efficient method for RNA modification with high sequence and base selectivity using non-natural functional ODN (2013)
  • Author(s): Shigeki Sasaki, Daichi Jitsuzaki, Atsushi Nishimoto, Kazumitsu Onizuka, Fumi Nagatsugi, Yosuke Taniguchi
  • Organizer: Gordon Research Confernces
  • Place of Presentation: Salve Regina University(USA)
  • Year and Date: 20130630-20130705
• [Presentation] 遷移金属カチオン活性化機構をもつ機能性人工核酸を用いた部位特異的特異的RNA修飾化学修飾反応 (2013)
  • Author(s): 實崎大地、鬼塚和光、西本篤史、谷口陽祐、佐々木茂貴
  • Organizer: 日本ケミカルバイオロジー第８回年会
  • Place of Presentation: 東京 東京医科歯科大学
  • Year and Date: 20130619-20130621
• [Presentation] 繰り返し配列を含むDNAに対して協奏的に集積する低分子化合物の合成および評価 (2013)
  • Author(s): 江田裕則、John BRAZIER、佐々木茂貴
  • Organizer: 日本ケミカルバイオロジー第８回年会
  • Place of Presentation: 東京 東京医科歯科大学
  • Year and Date: 20130619-20130621
• [Presentation] 2-aminoAdapによるDNA中の8-oxodG検出法の開発 (2013)
  • Author(s): 谷口陽祐、深堀慶太郎、古賀洋平、佐々木茂貴
  • Organizer: 日本ケミカルバイオロジー第８回年会
  • Place of Presentation: 東京 東京医科歯科大学
  • Year and Date: 20130619-20130621
• [Presentation] 塩基欠損部位を持つ2本鎖DNAにおける化学修飾法の開発 (2013)
  • Author(s): 佐藤憲大、茂木琢真、萩原伸也、永次 史
  • Organizer: 日本ケミカルバイオロジー第８回年会
  • Place of Presentation: 東京 東京医科歯科大学
  • Year and Date: 20130619-20130621
• [Presentation] 効率的遺伝子発現制御を目指した高い架橋形成能を持つビニルプリン誘導体の開発 (2013)
  • Author(s): 草野 修平、岩本 直生、萩原 伸也、永次 史
  • Organizer: 日本ケミカルバイオロジー第８回年会
  • Place of Presentation: 東京 東京医科歯科大学
  • Year and Date: 20130619-20130621
• [Presentation] 遺伝子を標的とした新規機能性低分子プローブの開発 (2013)
  • Author(s): 永次 史、茂木 琢磨、草野修平、佐藤憲大
  • Organizer: 第３回領域公開シンポジウム
  • Place of Presentation: 筑波
  • Year and Date: 20130528-20130529
• [Presentation] ミトコンドリアを標的とした遺伝子発現制御の試み (2013)
  • Author(s): 山田勇磨、 古川亮、原島秀吉.
  • Organizer: 日本薬剤学会第28年会
  • Place of Presentation: 名古屋 (ウインクあいち)
  • Year and Date: 20130525-20130525
• [Presentation] 細胞内における遺伝子発現制御を目指した選択的架橋反応性核酸の開発 (2013)
  • Author(s): 永次 史
  • Organizer: 日本薬学会東海支部特別講演会
  • Place of Presentation: 岐阜薬大 岐阜
  • Year and Date: 20130524-20130524
  • Invited
• [Presentation] DNAマイクロアレイとin vivo siRNA送達システムの融合による新規2型糖尿病治療薬創出 (2013)
  • Author(s): 末光永理奈、林泰弘、梶本和昭、佐藤悠介、Afsana Akhter、櫻井遊、畠山浩人、兵藤守、加地範匡、馬場嘉信、原島秀吉
  • Organizer: 日本薬剤学会第28年会
  • Place of Presentation: 名古屋 (ウインクあいち)
  • Year and Date: 20130523-20130525
• [Presentation] 膵β細胞株MIN6細胞を標的としたDDS, β-MENDの構築および核酸導入・機能発現の検証 (2013)
  • Author(s): 田端麻衣、山田勇磨、 安崎友香理、野村政壽、柴田篤志、佐々木茂樹、原島秀吉
  • Organizer: 日本薬学会北海道支部第140回例会
  • Place of Presentation: 札幌(札幌コンベンションセンター)
  • Year and Date: 20130518-20130518
• [Presentation] Development of the Strategy for th Selective Chemical Modification to an Abasic Site in Duplex DNA (2013)
  • Author(s): Norihiro Sato, Takuma Moki, Shinya Hagihara, Fumi Nagatsugi
  • Organizer: 4th UK/Japan Conference in Catalytic Asymmetric Synthesis
  • Place of Presentation: Sendai
  • Year and Date: 20130419-20130420
• [Presentation] Molecular design and synthesis for selective recognition and reaction of DNA and RNA (2013)
  • Author(s): Shigeki Sasaki
  • Organizer: Report of Lectureship in Hong Kong
  • Place of Presentation: The Chinese University of Hong Kong
  • Year and Date: 20130416-20130421
  • Invited