2013 Fiscal Year Final Research Report
Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides
| Project/Area Number |
21229002
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SASAKI Shigeki 九州大学, 薬学研究科(研究院), 教授 (10170672)
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| Co-Investigator(Kenkyū-buntansha) |
HARASHIMA Hideyoshi 北海道大学, 薬学研究院, 教授 (00183567)
HYOUDOU Mamoru 北海道大学, 薬学研究院, 特任助教 (30548186)
NAGATSUGI Fumi 東北大学, 多元物質科学研究, 教授 (90208025)
SHINDO Mitsuru 九州大学, 先導物質化学研究所, 教授 (40226345)
NOMURA Masatoshi 九州大学, 医学部付属病院, 講師 (30315080)
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| Project Period (FY) |
2009-05-11 – 2014-03-31
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| Keywords | 核酸医薬 / 薬物送達 / ナノメディスン / 2型糖尿病 / 疾患モデルマウス |
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| Research Abstract |
Integrated research project for nucleic acids drug has been directed to nano-medicines that can target pathogenetic geneses. Achievements on chemical research for the artificial functional oligonucleotides, determination of the target genes, delivery system for selective targeting cells or tissues, and validation of the nano-medicine using model animals have been accumulates by mutual collaboration.
Newly-developed reactive oligonulceotides (ODN) are encapsulated in beta-MEND to target beta-cells, which are delivered into MIN6 cells of beta cell line, resulting in increase of insulin by releasing its native inhibition by miRNA-375 system. Bonkrekic acid, an apoptosis inhibitor, enhanced its activity by encapsulation in MITO-Porter, a mitochondria- targeting delivery system. siRNA targeting Drp1 gene was encapsulated in YSK-MEND (liver-targeting nano-envelope) for validate its effect for the model animal, and a potential as a new therapeutic approach has been suggested.
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[Journal Article] Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes2014
Author(s)
Hayashi Y., Suemitsu E., Kajimoto K., Sato Y., Akhter A., Sakurai Y., Hatakeyama H., Hyodo M., Kaji N., Baba Y., Harashima H
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Journal Title
Mol. Ther. Nucleic Acids
Volume: 3
Pages: e154
DOI
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[Journal Article] 4-Vinyl-Substituted Pyrimidine Nucleosides Exhibit the Efficient and SelectiveFormation of Interstrand Cross-Links with RNA and duplex DNA2013
Author(s)
Nishimoto, A., Jitsuzaki, D., Onizuka, K., Taniguchi, Y., Nagatsugi, F. and Sasaki, S
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Journal Title
Nucleic Acids Res
Volume: 41
Pages: 6774-6781
DOI
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[Journal Article] The crosslink formation of 2'-OMe oligonucleotide containing 2-amino-6-vinyl- purine protects mRNA from miRNA- mediated silencing2013
Author(s)
Hagihara, S. Lin, W.C.,, Kusano, S., Chao, X.G., Hori, T., Imoto, S., Nagatsugi, F.
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Journal Title
Chem Biochem
Volume: 14
Pages: 1427-1429
DOI
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[Journal Article] Molecular design, synthesis, and evaluation of novel potent apoptosis inhibitors inspired from bongkrekic acid2012
Author(s)
Okuda, K., Hasui, K., Abe, M., Matsumoto, K., Shindo, M
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Journal Title
Chem. Res. Toxicol
Volume: 25
Pages: 2253-2260
DOI
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