2012 Fiscal Year Final Research Report
StudiesonMetastasisofDigestiveCancersUsingMouseModels
| Project/Area Number |
21229005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKETO Makoto 京都大学, 大学院・医学研究科, 教授 (70281714)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Masahiro 京都大学, 大学院・医学研究科, 准教授 (60362464)
KITAMURA Takanori 京都大学, 大学院・医学研究科, 助教 (10378622)
SONOSHITA Masahiro 京都大学, 大学院・医学研究科, 准教授 (80511857)
AOKI Koji 京都大学, 大学院・医学研究科, 助教 (40402862)
FUJISHITA Teruaki 京都大学, 大学院・医学研究科, 助教 (50511870)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 分子腫瘍学 / 転移 |
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| Research Abstract |
Metastasis is responsible for most cancer deaths. Here, we show that immature myeloid cells (iMCs) promote liver metastasis of colon cancer cells. We also found that Notch signaling stimulates colon cancer metastasis, and endogenous metastasis suppressor Aes inhibits the signaling. In addition, we demonstrate that JNK stimulates tumor formation in the intestine by activating mTORC1 signaling. These results should open new horizons in metastasis research and treatment of colon cancer.
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Research Products
(28 results)
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[Journal Article] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2011
Author(s)
Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura K, Oshima M, and Taketo MM.
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Journal Title
Cancer Cell
Volume: 19
Pages: 125-137
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