2013 Fiscal Year Final Research Report
Analyses of transcription factors networks that govern T lymphocyte development
| Project/Area Number |
21229008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
TANIUCHI Ichiro 独立行政法人理化学研究所, その他部局等, その他 (20284573)
|
|---|
| Project Period (FY) |
2009-05-11 – 2014-03-31
|
| Keywords | リンパ球 / T細胞 / 転写因子ネットワーク |
|---|
| Research Abstract |
T lymphocytes are known to play important roles in the control of the immune system that is essential to maintain homeostasis in our body, thereby keeping our health. It is therefore important to understand molecular mechanisms that govern differentiation of several T lymphocyte subsets. This study mainly focused on a transcription factors network that regulates CD4-helper versus CD8-cytotoxic lineage determination and revealed that antagonistic interplay between ThPOK and Runx transcription factors is central to control this lineage dichotomy. In addition, this study not only provided novel insights into an epigenetic regulation of Thpok gene but also identified Bcl11b and SATB1 as novel upstream factors regulating Thpok gene expression. Furthermore, we found an unappreciated developmental plasticity retained in CD4+ T cells that allow them to be reprogrammed to acquire cytotoxic-related features upon exposure to the gut specific environment.
|
-
[Journal Article] CD4^+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC22014
Author(s)
Boucheron N, Tschismarov R, Goeschl L, Moser M.A, Lagger S, Sakaguchi S, Winter M, Lenz F, Vitko D, Breitwieser FP, Muller L, Hassan H, Bennett K.L, Colinge J, Schreiner W, Egawa T, Taniuchi I, Matthias P, Seiser C Ellmeier W
-
Journal Title
DOI
Peer Reviewed
-
-
-
[Journal Article] Transcriptional Reprogramming of Mature CD4 T helper Cells generates distinct MHC class II restricted Cytotoxic T Lymphocytes2013
Author(s)
Mucida D, Husain M.M, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis B, Huang Y, Lambolez F, Docherty M, Attinger A, Shui J.W, Kim G, Lena C, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, Taniuchi I and Cheroutre H
-
Journal Title
Nat. Immunol
Volume: 14
Pages: 281-9
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
