2012 Fiscal Year Final Research Report
High-throughput development of disease model mice by using next-generation technologies.
| Project/Area Number |
21240043
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
GONDO Yoichi 独立行政法人理化学研究所, 新規変異マウス研究開発チーム, チームリーダー (40225678)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMURA Ryutaro 独立行政法人理化学研究所, 新規変異マウス研究開発チーム, 開発研究員 (90392240)
MURATA Takuya 独立行政法人理化学研究所, 新規変異マウス研究開発チーム, 開発研究員 (70305001)
MAKINO Shigeru 独立行政法人理化学研究所, 新規変異マウス研究開発チーム, 開発研究員 (30462732)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKUCHI Jun 独立行政法人理化学研究所, 先端NMR メタボミクスチーム, チームリーダー (00321753)
KAWAI Jun 独立行政法人理化学研究所, LSA システム構築グループ, プロジェクトディレクター (30391923)
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| Project Period (FY) |
2009 – 2012
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| Keywords | マウス遺伝学 / 逆遺伝学 / ゲノム機能 / ミュータジェネシス / 突然変異 / 次世代シーケンシング / 量的遺伝 / ENU |
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| Research Abstract |
We have established ultra-throughput point mutation discovery system from the RIKEN ENU mutant mouse library. Based on this unique system, it is now possible to detect base substitutions with more than 1000-fold efficiency than those by conventional methods. The discovered mutations are openly available as live mutant mice to the research community. Furthermore, any epistatic interactions modeling complex traits/disease have also become detectable from the RIKNE ENU mutant mouse library.
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[Journal Article] The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis2013
Author(s)
Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, Maclean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP
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Journal Title
DOI
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[Journal Article] Epub ahead of print2013
Author(s)
Toki H, Inoue M, Motegi H, Minowa O, Kanda H, Yamamoto N, Ikeda A, Karashima Y, Matsui J, Kaneda H, Miura I, Suzuki T, Wakana S, Masuya H, Gondo Y, Shiroishi T, Akiyama T, Yao R, Noda T
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Journal Title
Cancer Sci
Volume: PMID: 23551873
Pages: PMID: 23551873
DOI
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[Journal Article] ENU mutagenesis screening for dominant behavioral mutations based on normal control data obtained in home-cage activity, open-field, and passive avoidance tests2010
Author(s)
Wada Y, Furuse T, Yamada I, Masuya H, Kushida T, Shibukawa Y, Nakai Y, Kobayashi K, Kaneda H, Gondo Y, Noda T, Shiroishi T, Wakana S
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Journal Title
Exp Anim
Volume: 59(4)
Pages: 495-510
DOI
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[Journal Article] Phenotypic characterization of a new Grin1 mutant mouse generated by ENU mutagenesis. Eur J Neurosci2010
Author(s)
Furuse T, Wada Y, Hattori K, Yamada I, Kushida T, Shibukawa Y, Masuya H, Kaneda H, Miura I, Seno N, Kanda T, Hirose R, Toki S, Nakanishi K, Kobayashi K, Sezutsu H, Gondo Y, Noda T, Yuasa S, Wakana S
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Journal Title
Eur J Neurosci
Volume: 31(7)
Pages: 1281-1291
DOI
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[Journal Article] A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice2010
Author(s)
Sato H, Suzuki T, Ikeda K, Masuya H, Sezutsu H, Kaneda H, Kobayashi K, Miura I, Kurihara Y, Yokokura S, Nishida K, Tamai M, Gondo Y, Noda T, Wakana S
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Journal Title
Mol Vis
Volume: 16
Pages: 378-91
DOI
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[Journal Article] Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model2009
Author(s)
Labrie, V., Fukumura, R., Rastogi, A., Fick, L.J., Wang, W., Boutros, P.C., Kennedy, J.L., Semeralul, M.O., Lee, F.., Baker, G.B., Belsham, D.D., Barger, S.W., Gondo, Y., Wong, A.H.C., Roder, J.C
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Journal Title
Human Molecular Genetics
Volume: 18(17)
Pages: 3227-3243
DOI
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