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2012 Fiscal Year Final Research Report

Development of optical transillumination system to realize imaging of 3D structure using new principles

Research Project

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Project/Area Number 21240045
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHokkaido University

Principal Investigator

SHIMIZU Koichi  北海道大学, 大学院・情報科学研究科, 教授 (30125322)

Co-Investigator(Kenkyū-buntansha) KUDO Nobuki  北海道大学, 大学院・情報科学研究科, 准教授 (30271638)
KATO Yuji  北海道大学, 大学院・情報科学研究科, 助教 (50261582)
KITAMA Masataka  北海道工業大学, 医療工学部, 教授 (50285516)
CHIBA Hitoshi  北海道大学, 大学院・保健科学研究院, 教授 (70197622)
Project Period (FY) 2009 – 2012
Keywords生体透視 / 3次元光透視 / 近赤外光 / 光散乱 / 点拡がり関数 / 近軸散乱光 / 光拡散 / 時間分解解析
Research Abstract

To realize 3D transillumination imaging of internal structure and function of biological body, we developed new techniques based on original principles and created the systems to verify them. In this study, the feasibility of imaging the internal structure of experimental animals and human limbs using safe near-infrared light without radio-active exposure was verified. The feasibility of functional imaging such as tissue oxygenation state was also verified.

  • Research Products

    (43 results)

All 2013 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (19 results) Book (1 results) Patent(Industrial Property Rights) (15 results) (of which Overseas: 3 results)

  • [Journal Article] 生体組織における光伝搬の解析2012

    • Author(s)
      清水孝一
    • Journal Title

      光学

      Volume: 41巻 Pages: 414-423

    • Peer Reviewed
  • [Journal Article] 画像差分シュリーレン法による超音波音場の可視化2011

    • Author(s)
      工藤信樹,清水孝一
    • Journal Title

      超音波医学

      Volume: 38巻 Pages: 25-26

    • Peer Reviewed
  • [Journal Article] Measurement of lipoprotein parti cle sizes using dynamic light scattering2010

    • Author(s)
      T. Sakurai, S. Trirongjitmoah, Y. Nishibata, T.Namita, M. Tsuji, S. P. Hui, S. Jin, K. Shimizu and H. Chiba
    • Journal Title

      Annals of Clinical Biochemistry

      Volume: 47 Pages: 476-481

    • Peer Reviewed
  • [Journal Article] Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering2010

    • Author(s)
      S. Trirongjitmoah, T. Sakurai, K. Iinaga, H.Chiba and K. Shimizu
    • Journal Title

      Optics Express

      Volume: 18 Pages: 6315-6326

    • Peer Reviewed
  • [Journal Article] 光干渉法による散乱体内部超音波変調信号の検出2009

    • Author(s)
      加藤祐次,清水孝一
    • Journal Title

      電子情報通信学会論文誌

      Volume: J92-D巻 Pages: 944-950

    • Peer Reviewed
  • [Journal Article] CW transillumination imaging by extracting weakly scattered light from strongly diffused light2009

    • Author(s)
      K. Takagi, H. Kakinuma Y. Kato and K.Shimizu
    • Journal Title

      Optics Express

      Volume: 17 Pages: 8332-8342

    • Peer Reviewed
  • [Journal Article] CT im-aging of diffuse medium by time-resolved measurement of backscattered light2009

    • Author(s)
      T. Namita, Y. Kato and K. Shimizu
    • Journal Title

      Applied Optics

      Volume: 48 Pages: D208-D217

    • Peer Reviewed
  • [Journal Article] Extrac-tion of near-axis scattered light for transillumina-tion imaging2009

    • Author(s)
      K.Takagi,Y.Kato and K. Shimizu
    • Journal Title

      Applied Optics

      Volume: 48 Pages: D36-D44

    • Peer Reviewed
  • [Presentation] Feasibility study for optical BAN2013

    • Author(s)
      J. Akiyama, D. Seki, T. Namita, Y. Kato andK. Shimizu
    • Organizer
      7th International Symposium on Medical Infor- mation and Communication Technology
    • Place of Presentation
      Meiji University, Tokyo, Japan
    • Year and Date
      20130306-08
  • [Presentation] Funda- mental study for optical BAN2012

    • Author(s)
      K. Shimizu, T. Namita and Y. Kato
    • Organizer
      3rd International Conference on Wireless Mobile Communication and Healthcare
    • Place of Presentation
      Villa Modigliani, Paris, France.
    • Year and Date
      20121121-23
  • [Presentation] Fundamental study for optical communica- tion through human body2012

    • Author(s)
      K. Shimizu, J. Akiyama, T. Namita and Y. Kato
    • Organizer
      International Sympo- sium on Biotelemetry
    • Place of Presentation
      Weitzer Hotels BetriebsgesmbH, Graz, Austria.
    • Year and Date
      20120524-26
  • [Presentation] Point spread function for optical transillu- mination imaging of animal body2012

    • Author(s)
      K. Shimizu, H. Takahashi, T. Namita and Y. Kato
    • Organizer
      Progress in Electromagnetics Research Symposium
    • Place of Presentation
      Sunway Resort Hotel and Spa, Kuala Lumpur, Malaysia.
    • Year and Date
      20120327-30
  • [Presentation] 生体観察のための不要散乱抑制2012

    • Author(s)
      清水孝一
    • Organizer
      日本光学会(応用物理学会)冬期講習会
    • Place of Presentation
      東京大学山上会館,東京都
    • Year and Date
      20120119-20
  • [Presentation] Application of transillumination imaging to injection assist sys- tem2012

    • Author(s)
      K.Shimizu , N. Tobisawa, T. T. Nghia, T. Namita and Y. Kato
    • Organizer
      4th International Conference on Biomedical Engineering
    • Place of Presentation
      In-ter-Continental Asiana Saigon, Ho Chi Minh City, Viet Nam.
    • Year and Date
      20120108-12
  • [Presentation] Feasibility study for 3D reconstruction of internal structure of animal body using near-infrared light2012

    • Author(s)
      T. T. Nghia, T. Namita, Y. Kato and K. Shimizu
    • Organizer
      4th International Conference on Biomedical Engineering
    • Place of Presentation
      Inter-Continental Asiana Saigon, Ho Chi Minh City, Viet Nam.
    • Year and Date
      20120108-12
  • [Presentation] Reliable scattering coeffi- cient estimation against absorption inhomogene- ity by time-resolved measurement of backscat- tered light2011

    • Author(s)
      Takeshi Namita, Masayuki Kawashima, Y. Kato and K. Shimizu
    • Organizer
      Conference on Lasers and Elec- tro-Optics/Pacific Rim 2011
    • Place of Presentation
      Sydney Convention and Exhibition Centre, Sydney, Australia.
    • Year and Date
      20110828-0901
  • [Presentation] New technique to estimate non-absorbing temporal point spread function for diffuse optical tomography using backscattered light2011

    • Author(s)
      Takeshi Namita, Masafumi Otani, Y. Kato and K. Shimizu
    • Organizer
      Conference on Lasers and Elec- tro-Optics/Pacific Rim 2011
    • Place of Presentation
      Sydney Convention and Exhibition Centre, Sydney, Australia.
    • Year and Date
      20110828-0901
  • [Presentation] Reconstruction of three-dimensional structure in turbid medium by scattering suppres- sion2011

    • Author(s)
      M. Shimano, T. Namita, Y. Kato and K. Shimizu
    • Organizer
      Symposium on Photonics and Optoelec- tronics 2011
    • Place of Presentation
      East International Hotel, Wuhan, China.
    • Year and Date
      20110516-18
  • [Presentation] Injection assist system with surface and transillumination images2011

    • Author(s)
      N. Tobisawa, T. Namita, Y. Kato and K. Shimizu
    • Organizer
      5th International Con- ference on Bioinformatics and Biomedical Engi- neering
    • Place of Presentation
      Optics Valley King- dom Plaza, Wuhan, China.
    • Year and Date
      20110510-12
  • [Presentation] 光による生体透視イメ ージング2011

    • Author(s)
      清水孝一
    • Organizer
      Optical Solution Conference2011
    • Place of Presentation
      富士ソフトビル,東京都
    • Year and Date
      2011-10-14
  • [Presentation] Transillu- mination imaging of animal body with scattering suppression of NIR light2010

    • Author(s)
      K. Shimizu
    • Organizer
      日本生体医工学会大会
    • Place of Presentation
      大阪国際交流センター,大阪
    • Year and Date
      20100625-27
  • [Presentation] Optical imag- ing of biological tissues using ultra- sound-modulated light2010

    • Author(s)
      N. Kudo
    • Organizer
      日本生体医工学会大会
    • Place of Presentation
      大阪国際交流センター,大阪
    • Year and Date
      20100625-27
  • [Presentation] Functional transillu- mination imaging using near-infrared light2010

    • Author(s)
      K. Shimizu
    • Organizer
      日本生体医工学会大会
    • Place of Presentation
      大阪国際交流センター,大阪
    • Year and Date
      20100625-27
  • [Presentation] マクロな光技術の生体医工学応用2010

    • Author(s)
      清水孝一
    • Place of Presentation
      北海道大学,札幌
    • Year and Date
      2010-10-30
  • [Presentation] 近赤外光による生体内部構造および機能の透視イメージング2010

    • Author(s)
      清水孝一
    • Organizer
      医用近赤外線分光研究会
    • Place of Presentation
      旭川グランドホテル,旭川
    • Year and Date
      2010-10-16
  • [Presentation] 強散乱体における散乱・吸収計測法の開発2010

    • Author(s)
      清水孝一
    • Organizer
      電気学会光応用・ 視覚研究会
    • Place of Presentation
      北海道大学,札幌
    • Year and Date
      2010-02-02
  • [Presentation] Transillumination im- aging with scattering suppression technique2009

    • Author(s)
      K. Shimizu
    • Organizer
      Asian P acific S ympo sium on B iophotonics
    • Place of Presentation
      Shilla Ho tel, Jeju, Korea.
    • Year and Date
      2009-05-27
  • [Book] バイオメトリクス教科書2012

    • Author(s)
      清水孝一(分担執筆)
    • Total Pages
      192
    • Publisher
      コロナ社
  • [Patent(Industrial Property Rights)] 血中成分濃度測定装置および血中成 分濃度測定方法2012

    • Inventor(s)
      清水孝一,飯永一也
    • Industrial Property Rights Holder
      北海道大学,飯永一也
    • Industrial Property Number
      特許、特願2012- 267708
    • Filing Date
      2012-12-06
  • [Patent(Industrial Property Rights)] Component concentration measure- ment device and component concentration measurement method2012

    • Inventor(s)
      Kazuhiro Nishida,Koichi Shimizu
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、13/609,456
    • Filing Date
      2012-09-11
    • Overseas
  • [Patent(Industrial Property Rights)] 光吸収分布推定装置,濃度測定装置 及び光吸収係数分布推定装置の制御方法2012

    • Inventor(s)
      西田和弘,清水孝一,加藤祐次
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、2012-153552
    • Filing Date
      2012-07-09
  • [Patent(Industrial Property Rights)] 光吸収係数算出装置,濃度定量装置,光吸収係数算出方法,濃度定量方法,光吸収 係数の算出を行うプログラム及び濃度の算 出を行うプログラム2012

    • Inventor(s)
      西田和弘,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2012-139831
    • Filing Date
      2012-06-21
  • [Patent(Industrial Property Rights)] 濃度測定装置及び濃度測定装置の制 御方法2012

    • Inventor(s)
      西田和弘,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2012-135642
    • Filing Date
      2012-06-15
  • [Patent(Industrial Property Rights)] Concentration determination ap- paratus and concentration determination method2012

    • Inventor(s)
      Kazuhiro Nishida,Koichi Shimizu
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、13/493,384
    • Filing Date
      2012-06-11
    • Overseas
  • [Patent(Industrial Property Rights)] 成分濃度測定装置及び成分濃度測定 方法2012

    • Inventor(s)
      西田和弘,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2012-096316
    • Filing Date
      2012-04-20
  • [Patent(Industrial Property Rights)] Concentration measurement method and concentration measurement apparatus2012

    • Inventor(s)
      K. Nishida, K. Amano, K. Shimizu
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、13/425,537
    • Filing Date
      2012-03-21
    • Overseas
  • [Patent(Industrial Property Rights)] 濃度定量装置、濃度定量方法及びプログラム2012

    • Inventor(s)
      天野和彦,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2012-001185
    • Filing Date
      2012-01-06
  • [Patent(Industrial Property Rights)] 濃度定量装置、濃度定量方法及びプログラム2012

    • Inventor(s)
      天野和彦,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願 2012-001184
    • Filing Date
      2012-01-06
  • [Patent(Industrial Property Rights)] 成分濃度測定装置及び成分濃度測定方法2011

    • Inventor(s)
      西田和弘,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2011- 227932
    • Filing Date
      2011-10-17
  • [Patent(Industrial Property Rights)] 濃度定量方法及び濃度定量装置2011

    • Inventor(s)
      西田和弘,天野和彦,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2011- 203102
    • Filing Date
      2011-09-16
  • [Patent(Industrial Property Rights)] 水分量測定方法及び水分量測定装置2011

    • Inventor(s)
      西田和弘,天野和彦,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2011- 190537
    • Filing Date
      2011-09-01
  • [Patent(Industrial Property Rights)] 濃度定量装置及び濃度定量方法並びに プログラム2011

    • Inventor(s)
      天野和彦,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2011-185108
    • Filing Date
      2011-08-26
  • [Patent(Industrial Property Rights)] 濃度定量装置、濃度定量方法2011

    • Inventor(s)
      西田和弘,天野和彦,清水孝一
    • Industrial Property Rights Holder
      セイコーエプソン,北海道大学
    • Industrial Property Number
      特許、特願2011-137316
    • Filing Date
      2011-06-21

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Published: 2014-08-29  

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