2011 Fiscal Year Final Research Report
Development of in vivo imaging probe specific for hypoxic diseases
| Project/Area Number |
21240049
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Institute of Technology (2010-2011)
Kyoto University (2009) |
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Principal Investigator |
KONDOH Shinae 東京工業大学, 大学院・生命理工学研究科, 教授 (40314182)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Fumihiko 東北薬科大学, 薬学部, 准教授 (40253471)
UMEDA Izumi 国立がん研究センター, 臨床開発センター, 室長 (40160791)
KONDOH Gen 京都大学, 再生医科学研究所, 准教授 (40243258)
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| Project Period (FY) |
2009 – 2011
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| Keywords | バイオイメージング / 低酸素 / PETS / PECT |
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| Research Abstract |
A tumor-specific microenvironment is characterized by hypoxia. The hypoxic status of various solid tumors has been attributed as an indicator of adverse prognosis due to tumor progression toward a more malignant phenotype with increased metastatic potential and resistance to treatment. We have been developing a fusion protein that is specifically stabilized in hypoxic tumors. In this study, we had attempted to construct PET/SPECT probes with the fusion protein and explored the possibility of clinical application.
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[Journal Article] Evaluation of <125>^I-POS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor : Comparison among SPECT/CT imaging, autoradiography, and immune-histochemistry2011
Author(s)
Ueda M, Kudo T, Mutou Y, Umeda IO, Miyano A, Ogawa K, Ono M, Fujii H, Kizaka-Kondoh S, Hiraoka M, Saji H.
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Journal Title
Cancer Sci
Volume: 102(11)
Pages: 2090-6
Peer Reviewed
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[Journal Article] PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel(18) F-labeled biotin derivative2011
Author(s)
Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H.
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Journal Title
Mol Imaging Biol
Volume: 13(5)
Pages: 1003-10
Peer Reviewed
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