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2011 Fiscal Year Final Research Report

Surface modification of islets for increasing graft survival rate

Research Project

  • PDF
Project/Area Number 21240051
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKyoto University

Principal Investigator

IWATA Hiroo  京都大学, 再生医科学研究所, 教授 (30160120)

Co-Investigator(Kenkyū-buntansha) INAGAKI Nobuya  京都大学, 医学研究科, 教授 (30241954)
UEMOTO Shinji  京都大学, 医学研究科, 教授 (40252449)
KAWAMOTO Takuo  京都大学, 放射性同位元素総合センター, 教授 (10231276)
OKITSU Teru  京都大学, 医学研究科, 助教 (10378672)
TERAMURA Yuji  京都大学, 放射性同位元素総合センター, 助教 (10365421)
TONAMI Hiroyuki  京都大学, 再生医科学研究所, 助教 (90420405)
Project Period (FY) 2009 – 2011
Keywords細胞・組織工学 / バイオ人工膵臓
Research Abstract

Regenerative medicine and tissue engineering have opened new therapeutic domains. One of the more successful endeavors has been the transplantation of islets of Langerhans(islets), which produce and release insulin, as a treatment for patients with type 1 diabetes. However, when implanted into living tissue, islets can induce various undesirable biological responses, including blood coagulation, complement activation, inflammatory reactions, and immune reactions. We developed a new method in whichproteins and cells are immobilized on the islet surface to increase their compatibility with a host environment. Islet surface is modified with the ssDNA-PEG-lipid. Proteins or cells are modified with a ssDNA' that is complementary to the ssDNA. The proteins or the cells can be immobilized on the cell through hybridization between the ssDNA and ssDNA'.

  • Research Products

    (42 results)

All 2012 2011 2010 2009 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (25 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Immobilization of soluble complementreceptor 1 on islets2011

    • Author(s)
      Luan NM, Teramura Y., Iwata H
    • Journal Title

      Biomaterials

      Volume: 32(22) Pages: 4539-4545

    • DOI

      DOI:10.1016/j.biomaterials.2011.03.017

    • Peer Reviewed
  • [Journal Article] Layer-by-layer co-immobilization of solublecomplement receptor 1 and heparin on islets2011

    • Author(s)
      Luan NM, Teramura Y., Iwata H
    • Journal Title

      Biomaterials

      Volume: 32(27) Pages: 6487-6492

    • DOI

      DOI:10.1016/j.biomaterials.2011.05.048

    • Peer Reviewed
  • [Journal Article] Immobilization of anticoagulant-loadedliposomes on cell surfaces by DNAhybridization2011

    • Author(s)
      Chen H., Teramura Y., Iwata H
    • Journal Title

      Biomaterials

      Volume: 32(31) Pages: 7971-7977

    • DOI

      DOI:10.1016/j.biomaterials.2011.07.002

    • Peer Reviewed
  • [Journal Article] Co-immobilization of urokinase andthrombomodulin on islet surfaces by 6poly(ethyleneglycol)-conjugated phospholipid2011

    • Author(s)
      Chen H., Teramura Y., Iwata H
    • Journal Title

      Journal of Controlled Release

      Volume: 150(2) Pages: 229-234

    • DOI

      DOI:10.1016/j.jconrel.2010.11.011

    • Peer Reviewed
  • [Journal Article] Dynamics of Amphiphilic PolymersPEG-lipids and PVA-alkyl on the Cell Surface2010

    • Author(s)
      Inui O., Teramura T., Iwata H
    • Journal Title

      ACS Appl. Mater. Interfaces

      Volume: 2 Pages: 1514-1520

    • DOI

      DOI:10.1021/am100134v

    • Peer Reviewed
  • [Journal Article] Microencapsulation of Islets with LivingCells Using PolyDNA-PEG-Lipid Conjugate2010

    • Author(s)
      Teramura Y., Minh LN, Kawamoto T., IwataH
    • Volume
      21
    • Pages
      792-796
    • DOI

      DOI:10.1021/bc900494x

    • Peer Reviewed
  • [Journal Article] Bioartificial pancreas Microencapsulation and conformal coatingof islet of Langerhans2010

    • Author(s)
      Teramura Y., Iwata H
    • Journal Title

      Adv Drug Deliv Rev

      Volume: 62(7-8) Pages: 827-40

    • DOI

      DOI:10.1016/j.addr.2010.01.005

    • Peer Reviewed
  • [Journal Article] Cell surface modification with polymers for biomedical studies2010

    • Author(s)
      Teramura Y., Iwata H
    • Journal Title

      Soft Matter

      Volume: 6 Pages: 1081-1091

    • DOI

      DOI:10.1039/B913621E

    • Peer Reviewed
  • [Journal Article] Control of cell attachment through poly DNA hybridization2010

    • Author(s)
      Teramura Y., Chen H., Kawamoto T., Iwata H
    • Journal Title

      Biomaterials

      Volume: 31 Pages: 2229-2235

    • DOI

      DOI:10.1016/j.biomaterials.2009.11.098

    • Peer Reviewed
  • [Journal Article] Cryopreservation of primate embryonicstem cells with chemically-defined solutionwithout Me2SO2010

    • Author(s)
      Nishigaki T., Teramura Y., Suemori H., IwataH
    • Volume
      60
    • Pages
      159-164
    • DOI

      DOI:10.1016/j.cryobiol.2009.10.007

    • Peer Reviewed
  • [Journal Article] バイオ人工膵臓、膵β細胞の機能発揮に適した環境2009

    • Author(s)
      寺村裕治, 岩田博夫
    • Journal Title

      月間糖尿病

      Volume: 1巻 Pages: 77-86

  • [Journal Article] Cryopreserved agarose-encapsulated islets as bioartificial pancreas : a feasibility study2009

    • Author(s)
      Agudelo C A, Teramura Y, Iwata H
    • Journal Title

      Transplantation

      Volume: 87 Pages: 29-34

    • DOI

      DOI:10.1097/TP.0b013e318191b24b

    • Peer Reviewed
  • [Journal Article] Surface modification of islets with PEG-lipid for improvement of graft survival in intraportal transplantation2009

    • Author(s)
      Teramura Y., Iwata H
    • Journal Title

      Transplantation

      Volume: 88 Pages: 624-630

    • DOI

      DOI:10.1097/TP.0b013e3181b230ac

    • Peer Reviewed
  • [Journal Article] Islet encapsulation with living cells for improvement of biocompatibility2009

    • Author(s)
      Teramura Y., Iwata H
    • Journal Title

      Biomaterials

      Volume: 30 Pages: 2270-2275

    • DOI

      DOI:10.1016/j.biomaterials.2009.01.036

    • Peer Reviewed
  • [Journal Article] Complement activation by polymers carryinghydroxyl groups2009

    • Author(s)
      Arima Y., Kawagoe M., Toda M., Iwata H
    • Journal Title

      ACS Appl. Mater. Interfaces

      Volume: 1 Pages: 2400-2407

    • DOI

      DOI:10.1021/am9005463

    • Peer Reviewed
  • [Presentation] 免疫拒絶反応の抑制を目指した膵島表面へのセルトリ細胞固定化2010

    • Author(s)
      竹本直紘, 寺村裕治, 岩田博夫
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      グランドプリンスホテル広島(広島市)
    • Year and Date
      2010-11-30
  • [Presentation] オリゴDNAの相補対形成による膵島表面へのウロキナーゼ固定化2010

    • Author(s)
      竹本直紘, 寺村裕治, 岩田博夫
    • Organizer
      第5回日本バイオマテリアル学会関西若手研究発表会
    • Place of Presentation
      芝蘭会館山内ホール(京都市)
    • Year and Date
      2010-08-06
  • [Presentation] Islet microencapsulation within sCR1-immobilized agarose gel2010

    • Author(s)
      Luan, M. Nguyen, Teramura Y., Iwata H
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-05-27
  • [Presentation] PEG脂質を用いた生理活性物質の膵島表面への固定2010

    • Author(s)
      陳景、寺村裕治, 岩田博夫
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-05-26
  • [Presentation] ポリエチレングリコール結合脂質を用いた膵島の表面修飾と生着率の向上2010

    • Author(s)
      岩田博夫, 寺村裕治
    • Organizer
      第13回日本異種移植研究会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2010-03-14
  • [Presentation] 細胞表面修飾における膵島の生着率の向上2010

    • Author(s)
      寺村裕治, 岩田博夫
    • Organizer
      第37回日本膵・膵島移植研究会
    • Place of Presentation
      栃木県総合文化センター(宇都宮市)
    • Year and Date
      2010-03-13
  • [Presentation] 細胞間相互作用の解析を可能とする細胞の表面修飾2009

    • Author(s)
      寺村裕治, 山本英樹, 川本卓男, 岩田博夫
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2009-11-17
  • [Presentation] 細胞間相互作用を利用した膵ランゲルハンス島のカプセル化2009

    • Author(s)
      寺村裕治, 川本卓男, 岩田博夫
    • Organizer
      第31回日本バイオマテリアル学会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2009-11-17
  • [Presentation] PEG脂質を用いた生理活性物質の膵島表面への固定2009

    • Author(s)
      陳景, 寺村裕治, 岩田博夫
    • Organizer
      第31回日本バイオマテリアル学会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2009-11-17
  • [Presentation] 異種細胞間相互作用によるES細胞の三次元培養と分化制御2009

    • Author(s)
      山本英樹, 寺村裕治, 岩田博夫
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2009-11-17
  • [Presentation] 人工多能性幹細胞の凍結保存液の検討2009

    • Author(s)
      西垣達矢, 寺村裕治, 岩田博夫
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2009-11-17
  • [Presentation] 平面脂質膜と両親媒性高分子の相互作用解析2009

    • Author(s)
      山本寿弘, 寺村裕治, 岩田博夫
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2009-11-16
  • [Presentation] 細胞による膵ランゲルハンス島のカプセル化2009

    • Author(s)
      寺村裕治, 岩田博夫
    • Organizer
      47回日本人工臓器学会
    • Place of Presentation
      新潟大学(新潟市)
    • Year and Date
      2009-11-13
  • [Presentation] Cell adhesion behavior on well defined surfaces2009

    • Author(s)
      Iwata, H
    • Organizer
      3rd International Symposiumon Nanomedicine-Molecular Imagingfor System Biology-
    • Place of Presentation
      岡崎コンファレンスセンター(岡崎市)
    • Year and Date
      2009-11-04
  • [Presentation] Islets-encapsulation with living cells for improvement of biocompatibility2009

    • Author(s)
      Teramura Y., Takemoto N., Iwata H
    • Organizer
      IPITA-IXA 2009Joint meeting
    • Place of Presentation
      VeniceLido Congress Center(ベニス
    • Year and Date
      2009-10-15
  • [Presentation] Surface modificationof islets with PEG-lipid for improvementof graft survival in intraportal transplantation2009

    • Author(s)
      Teramura Y., Iwata H
    • Organizer
      IPITA-IX A 2009 Joint meeting
    • Place of Presentation
      Venice Lido CongressCenter(ベニス)
    • Year and Date
      2009-10-14
  • [Presentation] 両親媒性高分子を用いた細胞による膵ランゲルハンス島のカプセル化2009

    • Author(s)
      寺村裕治, 岩田博夫
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学(熊本市)
    • Year and Date
      2009-09-17
  • [Presentation] バイオインターフェイス-解析+設計+応用-2009

    • Author(s)
      岩田博夫
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学(広島市)
    • Year and Date
      2009-09-16
  • [Presentation] Cells surface modification witha ultra thin membrane2009

    • Author(s)
      Iwata, H
    • Organizer
      2009 InternationalWorkshop on Nano Biomedicine
    • Place of Presentation
      National Cheng Kung University(Taiwan)
    • Year and Date
      2009-08-21
  • [Presentation] サルES細胞の神経細胞への分化誘導とEGF固定化基板における選択2009

    • Author(s)
      山本英樹, 中路正, 藤田聡, 加藤功一, 岩田博夫
    • Organizer
      日本バイオマテリアル学会第4回関西若手研究発表会
    • Place of Presentation
      銀杏会館(大阪市)
    • Year and Date
      2009-08-07
  • [Presentation] 人工多能性幹細胞の凍結保存液の検討2009

    • Author(s)
      西垣達矢, 寺村裕治, 岩田博夫
    • Organizer
      日本バイオマテリアル学会第4回関西若手研究発表会
    • Place of Presentation
      銀杏会館(大阪市)
    • Year and Date
      2009-08-07
  • [Presentation] 平面脂質膜と両親媒性高分子の相互作用解析2009

    • Author(s)
      山本寿弘, 寺村裕治, 岩田博夫
    • Organizer
      日本バイオマテリアル学会第4回関西若手研究発表会
    • Place of Presentation
      銀杏会館(大阪市)
    • Year and Date
      2009-08-07
  • [Presentation] Cell surface modification forregenerative medicine2009

    • Author(s)
      Iwata, H
    • Organizer
      Nanobio-materials and technologies forbreakthrough in future medicine
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Year and Date
      2009-07-22
  • [Presentation] 高分子薄膜による表面プラズモン場励起蛍光法におけるエネルギー移動の抑制2009

    • Author(s)
      村上隆史, 岩田博夫, 有馬祐介, 戸田満秋
    • Organizer
      第55回高分子研究発表会
    • Place of Presentation
      兵庫県民会館(神戸市)
    • Year and Date
      2009-07-17
  • [Presentation] Biointerface-analysis+ design+ application2009

    • Author(s)
      Iwata, H
    • Organizer
      Biomaterials Asia 2009
    • Place of Presentation
      Regal Airport Hotel(Hong Kong)
    • Year and Date
      2009-04-08
  • [Book] Polymeric Biomaterials : Volume II, Medicinal and Pharmaceutical Applications of Polymers2012

    • Author(s)
      Teramura Y., Chen H., Takemoto N., Sakurai K., Iwata H
    • Publisher
      CRC Press
  • [Remarks]

    • URL

      http://www.frontier.kyoto-u.ac.jp/te03/index-j.htm

URL: 

Published: 2013-07-31  

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