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2011 Fiscal Year Final Research Report

Establishment of magnetic hyperthermic prostate cancer therapy using brachytherapy systems

Research Project

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Project/Area Number 21240055
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionOsaka University

Principal Investigator

NAKAGAWA Takashi  大阪大学, 大学院・工学研究科, 准教授 (70273589)

Co-Investigator(Kenkyū-buntansha) TACHIBANA Masaaki  東京医科大学, 医学部, 教授 (70129526)
OOHORI Makoto  東京医科大学, 医学部, 教授 (50203930)
HANDA Hiroshi  東京工業大学, 統合研究院, 教授 (80107432)
UEDA Tomoaki  東京工業大学, 統合研究院, 特任教授 (50456258)
YAMAMOTO Takao  大阪大学, 大学院・工学研究科, 教授 (00174798)
SEINO Satoshi  大阪大学, 大学院・工学研究科, 講師 (90432517)
Project Period (FY) 2009 – 2011
Keywords低侵襲治療システム / 前立腺がん / 磁気温熱療法
Research Abstract

Basic studies were performed to realize the combined therapy of the local radiation and the local hyperthermic treatments with less side-effects and high curative effect utilizing small seeds used for prostate cancer treatment also as heating mediators in magnetic hyperthermia. When applying the exchange magnetic field of 1 MHz and 50 Oe-rms, Ti needles, used as cold dummy of small seeds, functioned enough as heating mediators of magnetic hyperthermia through in-vivo tests. Moreover, it was found that the heat-shock protein(said to heighten the immunity effect) concentration in blood became high intentionally. This means that not only radiation and hyperthermia but also immune-therapies were expected when small seeds were used as heating mediators.

  • Research Products

    (10 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] 前立腺がんの治療用密封小線源を磁気ハイパーサーミア発熱体として併用する可能性の検証2011

    • Author(s)
      吉岡朋宏、中川貴、堀木麻由美、清野智史、山本孝夫、権藤立男、橋本剛、大堀理、阿部正紀
    • Journal Title

      J. Magn. Soc. Jpn

      Volume: 35(3) Pages: 330-333

    • Peer Reviewed
  • [Journal Article] 磁気ハイパーサーミア用自己温度制御発熱体としてのLSMCペロブスカイト焼結体の作製と交流磁場中での発熱特性評価2011

    • Author(s)
      堀木麻由美, 中川貴, 吉岡朋宏, 清野智史, 山本孝夫, 阿部正紀
    • Journal Title

      J. Magn. Soc. Jpn.

      Volume: 35(1) Pages: 22-26

    • Peer Reviewed
  • [Journal Article] 磁気ビーズのバイオメディカル応用2010

    • Author(s)
      中川貴, 清野智史, 山本孝夫, 阿部正紀
    • Journal Title

      低温工学

      Volume: Vol.45No.10 Pages: 436. 443

    • Peer Reviewed
  • [Presentation] La_<2/ 3> Sr_<1/ 3> Mn_<1-x> Cu_xO_3ペロブスカイト球の合成と交流磁場中での発熱特性評価2011

    • Author(s)
      堀木麻由美, 中川貴, 清野智史, 山本孝夫
    • Organizer
      第108回粉体粉末冶金協会
    • Place of Presentation
      大阪大学
    • Year and Date
      20111026-28
  • [Presentation] Hyperthermic in vivo experiments using Ti needles as magnetic induction heating mediators2011

    • Author(s)
      Nakagawa, T.; Yoshioka, T.; Horiki, M.; Seino, S.; Yamamoto, T. A.; Abe, M.; Gondo, T.; Hashimoto, T.; Tachibana, M.; Ohori, M.
    • Organizer
      INTERMAG 2011 Conference
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      20110425-29
  • [Presentation] 密封小線源治療用チタンを用いた新しい前立腺磁気温熱治療の開発2010

    • Author(s)
      権藤立男, 大堀理, 中川貴, 橋本剛, 秦野直, 橘政昭
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      20100922-24
  • [Presentation] 前立腺がん治療用密封小線源の磁気ハイパーサーミアへの応用2010

    • Author(s)
      中川貴, 吉岡朋宏, 堀木麻由美, 清野智史, 山本孝夫, 権藤立男, 橋本剛, 橘政昭, 大堀理, 川島啓, 多田大, 半田宏, 阿部正紀
    • Organizer
      第34回日本磁気学会学術講演会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      20100904-07
  • [Presentation] Development of various types of heating mediators for anti-cancer hyperthermia2009

    • Author(s)
      Takashi Nakagawa, Masaru Tada, Tomoaki Ueda, Masanori Abe, Hiroshi Handa, Makoto Ohori
    • Organizer
      第33回日本磁気学会学術講演会
    • Place of Presentation
      長崎大学
    • Year and Date
      20090912-15
  • [Presentation] 密封小線源を磁気ハイパーサーミア発熱体に用いる前立腺がん治療法の開発2009

    • Author(s)
      中川貴, 川島啓, 多田大, 上田智章, 半田宏, 阿部正紀, 大堀理, 橘政昭, 清野智史, 山本孝夫
    • Organizer
      日本ハイパーサーミア学会第26回大会
    • Place of Presentation
      千葉大学
    • Year and Date
      20090911-12
  • [Remarks]

    • URL

      http://www.mit.eng.osaka-u.ac.jp/mt2/yamamotolab.html

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Published: 2013-07-31  

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