2012 Fiscal Year Final Research Report
Development of a photo-driven molecular machine with photo-responsive DNA
| Project/Area Number |
21241031
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
LIANG Xingguo 名古屋大学, 大学院・工学研究科, 准教授 (60447828)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 光応答性 DNA / アゾベンゼン / 分子マシン |
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| Research Abstract |
In this project, we aimed at creating new photo-driven DNA machines with photo-responsive DNA involving azobenzenes. First, we designed a newly modified azobenzene that enables efficient photo-regulation of DNA hybridization. We found that modification of a distal benzene ring at two ortho-positions was effective for the improvement of both photoregulatory efficiency and thermal stability of cis-form. Furthermore, we also clarified that the modified duplex of alternating base-pair and azobenzene residues allowed complete photo-regulation of DNA hybridization only by light-irradiation. Based on these results, we successfully constructed 1) photo-driven DNA machine that can reversibly digest target RNA, 2) photo-degradable DNA nano-capsule, and 3) DNA machine that can move like seesaw by the combination with visible light-responsive azobenzene.
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[Journal Article] Robust and photo-controllable DNA capsules using azobenzenes2010
Author(s)
Tanaka, F.; Mochizuki, T.; Liang, X.G.; Asanuma, H.; Tanaka, S.; Suzuki, K.; Kitamura, S.; Nishikawa, A.; Ui-Tei, K.; Hagiya, M
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Journal Title
Nano Lett.
Volume: 10
Pages: 3560-3565
Peer Reviewed
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