2011 Fiscal Year Final Research Report
Mammalian organ regeneration method using the roadmap for amphibian organogenesis.
| Project/Area Number |
21241048
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied genomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ASASHIMA Makoto 東京大学, 大学院・総合文化研究科, 名誉教授 (00090564)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yuzuru 産業技術総合研究所, 幹細胞工学研究センター, 研究チーム長 (30500079)
ARIIZUMI Takashi 玉川大学, 農学部, 教授 (30286166)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 臓器 / 幹細胞 / 分化 / 再生 / ES細胞 / 心臓 |
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| Research Abstract |
The establishment of efficient methods for promoting stem cell differentiation into target cells is important in regenerative medicine. Although various stem cells, such as ES and iPS cells, are being described, there remains a lack of protocols for inducing the differentiation of these cells. Based on the in vitro organogenesis methods using Xenopus, we have identified many "roadmap" genes that are indispensable for normal development in various organs. We have applied the roadmap of the amphibian organogenesis to mammalian stem cells, so as to facilitate the development of efficient methodologies for in vitro differentiation.
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[Journal Article] The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme2011
Author(s)
Yoshiyama-Yanagawa T, Enya S, Shimada-Niwa Y, Yaguchi S, Haramoto Y, Matsuya T, Shiomi K, Sasakura Y, Takahashi S, Asashima M, Kataoka H, Niwa R
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Journal Title
J Biol Chem
Volume: 286
Pages: 25756-25762
Peer Reviewed
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[Journal Article] Glycome diagnosis of human induced pluripotent stem cells using lectin microarray2011
Author(s)
Tateno H., Toyoda M., Saito S., Onuma Y., Ito Y., Hiemori K., Fukumura M., Nakasu A., Nakanishi M., Ohnuma K., Akutsu H., Umezawa A., Horimoto K., Hirabayashi J., Asashima M
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 20345-20353
Peer Reviewed
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[Journal Article] Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb2011
Author(s)
Kuwabara T., Kagalwala M. N., Onuma Y., Ito Y., Warashina M., Terashima K., Sanosaka T., Nakashima K., Gage F. H., Asashima, M
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Journal Title
EMBO Mol. Med
Volume: 3
Pages: 742-754
Peer Reviewed
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[Journal Article] Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder-and Serum-Free Defined Conditions2010
Author(s)
Hayashi Y, Chan T-C, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Kusuda Furue M, Michiue T, Ohnuma K, Nakauchi H, Asashima M
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Journal Title
Plos One
Volume: 5
Pages: 14099
Peer Reviewed
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