2011 Fiscal Year Final Research Report
Total Synthesis and Functional Analysis of Complex Natural Products
| Project/Area Number |
21241050
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
SASAKI Makoto 東北大学, 大学院・生命科学研究科, 教授 (80235267)
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| Co-Investigator(Kenkyū-buntansha) |
FUWA Haruhiko 東北大学, 大学院・生命科学研究科, 准教授 (90359638)
KONOKI Keiichi 東北大学, 大学院・農学研究科, 准教授 (40292825)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生物活性分子の設計・合成 / 天然物全合成 |
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| Research Abstract |
Efficient synthetic routes to architecturally complex natural products with potent biological activities and molecular weights over 500 have been developed for exploring their biological functions. In particular, the first total synthesis and complete stereostructure determination of gambieric acid A have been accomplished. An efficient total synthesis of polycavernoside A has been also achieved in a convergent approach. In addition, efficient synthetic routes to the C1. C16 and C12. C36 fragments of goniodomin A have been developed by exploiting Stille-type coupling of thioesters.
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