2011 Fiscal Year Final Research Report
Study on Peptide Display on Liposome Membranes for Disaggregation of Amyloid Fibrils
| Project/Area Number |
21246121
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biofunction/Bioprocess
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIMANOUCHI Toshinori 大阪大学, 大学院・基礎工学研究科, 助教 (10335383)
HIROSHI Umakoshi 大阪大学, 大学院・基礎工学研究科, 准教授 (20311772)
YOSHIMOTO Makoto 山口大学, 医学系・研究科 (80322246)
SHIOMORI Kouichiro 宮崎大学, 工学研究科, 准教授 (80235506)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
GOTO Yuji 大阪大学, 蛋白質研究所, 教授 (40153770)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | メンブレン・ストレスバイオテクノロジー / LIPOzyme / 生体膜 / 人工酵素 / バイオリアクター |
|---|
| Research Abstract |
We systematically investigated the polymorphism of amyloid Aβ/ Cu fibrils and their catalytic oxidation activity using the liposome as a model biomembrane. It was clarified that the oxidized surface of liposome could affect the catalytic oxidation activity of amyloids as well as their morphology. It was revealed that the experiments using peptide fragments-displayed liposomes could contribute to the better understanding on the regulatory mechanism of catalytic oxidation activity of Aβ/ Cu. Besides, we developed the novel loading method of liposomes into the module. Those results suggested that a recognition system of abnormal/ damaged biomembranes for their repairmen could be in principle developed, from those results.
|
