2012 Fiscal Year Final Research Report
Roles of the ribosomal RNA gene to maintain genome stability
| Project/Area Number |
21247003
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IIDA Tetsushi 国立遺伝学研究所, 細胞遺伝研究系, 助教 (60391851)
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| Project Period (FY) |
2009 – 2012
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| Keywords | リボソームRNA遺伝子 / ゲノムの安定性 / 細胞老化 / 染色体分配 / 出芽酵母 |
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| Research Abstract |
The genes encoding ribosomal RNA are the most abundant genes in the eukaryotic genome. They reside in tandem repetitive clusters, in some cases totaling hundreds of copies. Due to their repetitive structure, the ribosomal RNA gene repeats are some of the most fragile sites in the chromosome. The unusual nature of ribosomal RNA gene repeats affects cellular functions. In this study, we established a system in which rDNA stability is artificially manipulated and found that rDNA stability affects the yeast lifespan. In addition, we found that the copy number determines sensitivity to DNA damage, especially, non-transcibed copies function as "foothold" for repair enzymes. Moreover, repeat length affect the chromosome segregation rate.
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[Remarks] 平成24年度文部科学大臣表彰(研究部門)受賞(2012)
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[Remarks] 朝日新聞(科学面)、「余分な遺伝子は実はDNAを守っていた」2010年2月16日掲載
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[Remarks] 科学新聞(2面)、「働かない遺伝子の役割」2010年2月掲載
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[Remarks] 朝日新聞(科学面)、「細胞老化に関与の遺伝子」2009年9月25日掲載
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[Remarks] 東京新聞(科学面)、「細胞老化の鍵ゲノム特定領域に」2009年9月11日掲載
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[Remarks] 中日新聞(1面)、「細胞老化に関する遺伝子領域を特定」2009年9月11日掲載
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[Remarks] 静岡新聞(科学面)、「細胞若返りの鍵ゲノム領域」2009年9月11日掲載
