Study for epigenetic control through cross-talk among biomolecules

2011 Fiscal Year Final Research Report

• Project/Area Number: 21247016
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: University of Tsukuba
• Principal Investigator: YANAGISAWA Junn 筑波大学, 生命環境系, 教授 (50301114)
• Project Period (FY): 2009 – 2011
• Keywords: エピジェネティクス / 転写 / エネルギー代謝 / 核内レセプター / ネットワーク

Research Abstract

Some bio-molecules, such as hormones, regulate transcription through epigenetic control of genes. In this study, we have focused on such bio-molecules, and investigated the mechanisms of bio-molecule-dependent epigenetic control. From our study, we have successfully developed chemical compounds which are able to control epigenetic status and cure some diseases, such as cancers and fibrosis.

Research Products

• [Journal Article] Enhancer of rudimentary homolog (ERH) plays an essential role in the progression of mitosis by promoting mitotic chromosome alignment (2012)
  • Author(s): Fujimura A, Kishimoto H, Yanagisawa J, Kimura K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 423 Pages: 588-92
  • Peer Reviewed
• [Journal Article] Global analysis of DNA methylation in early-stage liver fibrosis (2012)
  • Author(s): Komatsu Y, Waku T, Iwasaki N, Ono W, Yamaguchi C , Yanagisawa J
  • Journal Title: BMC Medical Genomics Volume: 5 Pages: 5
  • Peer Reviewed
• [Journal Article] The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis (2011)
  • Author(s): Kajiro M, Tsuchiya M, Kawabe Y, Furumai R, Iwasaki N, Hayashi Y, Katano M, Nakajima Y, Goto N, Watanabe T, Murayama A, Oishi H, Ema M, Takahashi S, Kishimoto H, Yanagisawa J
  • Journal Title: PLoS One Volume: 6(10) Pages: e25871.
  • Peer Reviewed
• [Journal Article] Estrogen and antiestrogens alter breast cancer invasiveness by modulating TGF- βsignaling pathway (2011)
  • Author(s): Goto N, Hiyoshi H, Ito I, Tsuchiya M, Nakajima Y, Yanagisawa J.
  • Journal Title: Cancer Science Volume: 102(8) Pages: 1501-8
  • Peer Reviewed
• [Journal Article] Novel nucleolar pathway connecting intracellular energy status with p53 activation (2011)
  • Author(s): Kumazawa T, Nishimura K, Kuroda T, Ono W, Yamaguchi C, Katagiri N, Tsuchiya M, Masumoto H, Nakajima Y, Murayama A, Kimura K, Yanagisawa J
  • Journal Title: J. Biol. Chem Volume: 286(23) Pages: 20861-9
  • Peer Reviewed
• [Journal Article] Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5 (2011)
  • Author(s): Nakajima Y, Akaogi K, Suzuki T,Osakabe A, Yamaguchi C, Sunahara N, Ishida J, Kako K, Ogawa S, Fujimura T, Homma Y, Fukamizu A, Murayama A, Kimura K, Inoue S, Yanagisawa J
  • Journal Title: Science Signaling Volume: 4(168) Pages: ra22
  • Peer Reviewed
• [Journal Article] Critical role of the nucleolus in activation of the p53-dependent postmitotic checkpoint (2011)
  • Author(s): Tsuchiya M, Katagiri N, Kuroda T, Kishimoto H, Nishimura K, Kumazawa T, Iwasaki N, Kimura K, Yanagisawa J
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 407(2) Pages: 378-82
  • Peer Reviewed
• [Journal Article] RNA content in the nucleolus alters p53 acetylation via MYBBP1A (2011)
  • Author(s): Kuroda T, Murayama A, Katagiri N, Ohta Y, Fujita E, Masumoto H, Ema M, Takahashi S, Kimura K, Yanagisawa J
  • Journal Title: EMBO J Volume: 30(6) Pages: 1054-1066
  • Peer Reviewed
• [Journal Article] Estrogen inhibits transforming growth factor β signaling by promoting Smad2/3 degradation (2010)
  • Author(s): Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J
  • Journal Title: J.Biol. Chem Volume: 285(19) Pages: 14747-14755
  • Peer Reviewed
• [Journal Article] The nucleolar protein NML regulates hepatic ATP levels during liver regeneration after partial hepatectomy (2009)
  • Author(s): Mikogai A, Yanagisawa J, Yasuzawa-Tanaka K, Murayama A
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 390(3) Pages: 591-596
  • Peer Reviewed
• [Presentation] 核小体ダイナミクス (2011)
  • Author(s): 柳澤 純
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学 札幌
  • Year and Date: 2011-06-27
• [Presentation] 核小体の新規機能と分子修飾 (2010)
  • Author(s): 柳澤 純
  • Organizer: 第33回日本分子生物学会年会 第82回日本生化学会大会合同大会ワークショップ
  • Place of Presentation: 神戸ポートアイランド 神戸
  • Year and Date: 20101207-10
• [Presentation] 核内受容体の新しいネットワークと化学物質による制御 (2010)
  • Author(s): 柳澤 純
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 就実大学 岡山
  • Year and Date: 20100328-30
• [Presentation] Epigenetic control of rDNA loci inresponse to intracellular energy status (2009)
  • Author(s): 柳澤 純
  • Organizer: 第32回日本分子生物学会年会ワークショップ
  • Place of Presentation: パシフィコ横浜 横浜
  • Year and Date: 20091209-12
• [Presentation] 核内受容体によるエピゲノム制御 (2009)
  • Author(s): 柳澤 純
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド神戸
  • Year and Date: 20091021-24
• [Patent(Industrial Property Rights)] 標的遺伝子の発現制御方法 (2012)
  • Inventor(s): 柳澤 純
  • Industrial Property Rights Holder: 国立大学法人筑波大学
  • Industrial Property Number: 特願2012-187212
  • Filing Date: 2012-08-28