2011 Fiscal Year Final Research Report
Innovative research on molecular systems of immune cells using combination of single molecule imaging and numerical modeling
| Project/Area Number |
21247019
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
TOKUNAGA Makio 東京工業大学, 大学院・生命理工学研究科, 教授 (00192659)
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| Co-Investigator(Renkei-kenkyūsha) |
SOGAWA Kumiko (SAKATA Kumiko) 東京工業大学, 大学院・生命理工学研究科, 准教授 (20291073)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 1分子イメージング / 分子システム / その場計測 / 3次元イメージング / マルチカラーイメージング / HILO照明法 / 分子定量 / 数値モデル |
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| Research Abstract |
Single molecule imaging coupled with the ability to simultaneously visualize several different proteins in cells has enabled the quantification of molecular dynamics, interactions, and kinetics. Based on these three-dimensional and temporal parameters, we examine numerical modeling and computer simulations of cell functions. Using the combination of single molecule quantification and "in silico" modeling, we opened up new frontiers for understanding cells as molecular systems.
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[Journal Article] Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity2009
Author(s)
Miletic AV, Graham DB, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Cemerski S, Kloeppel T, Billadeau DD, Kanagawa O, Tokunaga M, Swat W
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Journal Title
PLoS One
Volume: Vol.4
Pages: e6599
Peer Reviewed
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