2011 Fiscal Year Final Research Report
Actin filaments work as a negative tension sensor: elucidation of itsphysiochemical mechanism
| Project/Area Number |
21247021
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Hitoshi 名古屋大学, 医学系研究科, 准教授 (20171720)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYAKAWA Kimihide 名古屋大学, 工学研究科, 特任講師 (60467280)
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| Project Period (FY) |
2009 – 2011
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| Keywords | メカノセンサー / アクチン線維 / コフィリン / ゆらぎ / 1分子観察 / 分子動力学 |
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| Research Abstract |
The actin depolymerizing factor (ADF) cofilin was found to bind selectively to relaxed actin filaments and severed them, indicating that actin filaments work as a negative tension sensor through a tension dependent regulation of cofilin activity. It is supposed that increased torsional fluctuations of relaxed actin filaments accelerate the cofilin binding to them.
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[Journal Article] Protective role of Gipie, a Girdinfamily protein, in endoplasmic reticulum stress responses in endothelial cells2011
Author(s)
Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Maeda K, Hattori S, Hagikura M, Takahashi K, Sokabe M, Murakumo Y, Murohara T, Takahashi M
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Journal Title
Mol Biol Cell
Volume: 22(6)
Pages: 736-747
Peer Reviewed
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