2013 Fiscal Year Final Research Report
Reconsideration on the molecular identity of MPF
| Project/Area Number |
21247030
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Ochanomizu University (2012-2013)
Tokyo Institute of Technology (2009-2011) |
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Principal Investigator |
KISHIMOTO Takeo お茶の水女子大学, サイエンス&エデュケーションセンター, 客員教授 (00124222)
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| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Eiichi 東京工業大学, 大学院生命理工学研究科, 助教 (00323808)
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| Co-Investigator(Renkei-kenkyūsha) |
TACHIBANA Kazunori 東京工業大学, バイオ研究基盤支援総合センター, 准教授 (60212031)
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| Project Period (FY) |
2009-05-11 – 2013-03-31
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| Keywords | 細胞周期 / 卵細胞 / ＭＰＦ / サイクリンＢ-Cdk1/Cdc2 / Greatwallキナーゼ / Ensa/Arpp19 / PP2A-B55 |
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| Research Abstract |
MPF (maturation/M phase-promoting factor) is the universal inducer of M-phase in eukaryotic cells. It is currently accepted that MPF is identical to the kinase cyclin B-Cdk1. Here we show that MPF and cyclin B-Cdk1 are not synonymous, and istead, that MPF is a system consisting of cyclin B-Cdk1 and another kinase, Greatwall kinase.
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