2012 Fiscal Year Final Research Report
embryonic patterning by Nodal and Lefty
| Project/Area Number |
21247034
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Osaka University |
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Principal Investigator |
HAMADA Hiroshi 大阪大学, 生命機能研究科, 教授 (00208589)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRATORI Hidetaka 大阪大学, 生命機能研究科, 准教授 (90362590)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 胚発生 / Nodal シグナル / Lefty / 胚葉形成 / 体軸形成 |
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| Research Abstract |
1. We have clarified the origin and role of DVE in anterior-posterior patterning.
2. We have identified a number of FoxH1 target genes in the mouse embryo.
3. A retinoic acid-responsive enhancer regulates Nodal expression at the pre-gastrulation stage.
4. Cerl2 is the earliest responding gene to the nodal fluid flow.
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Research Products
(25 results)
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[Journal Article] Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA in the mouse embryo2012
Author(s)
Nakamura, T., Saito, D., Kawasumi, A., Shinohara, K., Asai, Y., Takaoka, K., Dong, F., Takamatsu, A., Belo, J.A., Mochizuki, A., and Hamada, H.
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Journal Title
Nat.Communic
Volume: 3
Pages: 1322
DOI
Peer Reviewed
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[Journal Article] Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd22012
Author(s)
Yoshiba, S., Shiratori, H., Kawasumi, A., Shinohara, K., Sasaki, G., Belo, J.A., Nonaka, S., Sasaki, H., Kuo, I., Ehrlich, B., Pennekamp, P., Dworniczak, B., and Hamada, H
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Journal Title
Science.
Volume: 338
Pages: 226-231
Peer Reviewed
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[Journal Article] Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo.2012
Author(s)
Shinohara, K.,* Kawasumi, A.,* Takamatsu, A., Yoshiba, S., Botilde, Y., Motoyama, N., Reith, W., Durand, B., Shiratori, H. and Hamada, H.
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Journal Title
(*equally contributed) Nature Commun
Volume: 3
Pages: 622
Peer Reviewed
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[Journal Article] Left-right asymmetry in the level of active Nodal protein produced in the node is translated into the asymmetry in the lateral plate of mouse embryo.2011
Author(s)
Kawasumi, A., Nakamura, T., Iwai, N., Yashiro, K., Saijoh, Y., Belo, J.A., Shiratori, H. and Hamada, H
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Journal Title
Dev Biol.
Volume: 353
Pages: 321-330
Peer Reviewed
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[Journal Article] Planar polarization of the node cells determines the rotation axis of the node cilia2010
Author(s)
Hashimoto, M., Shinohara, K., Wang, J., Ikeuchi, S., Meno, C., Yoshiba, S., Takada S., Hatta, K., Wynshaw-Boris, T.,and Hamada, H.
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Journal Title
Nat. Cell Biol
Volume: 12
Pages: 170-176
Peer Reviewed
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[Journal Article] Reversal of left-right asymmetry by aberrant Nodal signaling in the node of mouse embryos.2009
Author(s)
Oki, S., Kitajima, K., Belo, J.A., Yokoyama, T., Hamada, H.* and Meno, C.*
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Journal Title
(*corresponding authors). Development
Volume: 136
Pages: 3917-3925
Peer Reviewed
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[Journal Article] Antagonism between Smad1 and Smad2 signaling regulates formation of the distal visceral endoderm in the mouse embryo2009
Author(s)
Yamamoto M., Beppu, X., Takaoka, K., Meno, C., Li, E., Miyazono, K., and Hamada, H
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Journal Title
J. CellBiol
Volume: 184
Pages: 323-334
Peer Reviewed
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