2012 Fiscal Year Final Research Report
Fine Organic Synthesis based on Catalytic Regioselective Functionalization
| Project/Area Number |
21249001
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Tomoyuki 京都大学, 化学研究所, 助教 (20432320)
FURUTA Takumi 京都大学, 化学研究所, 准教授 (30336656)
|
|---|
| Project Period (FY) |
2009 – 2012
|
| Keywords | 位置選択性 / 配糖体天然物 / アシル化 / 全合成 / 幾何異性 / 遠隔位不斉誘導 |
|---|
| Research Abstract |
Short-step total synthesis of natural glycoside, tellimagrandin II, was achieved via organocatalytic regioselective acylation. A method for one-step regioselective functionalization of natural cardiac glycoside, lanatoside C, was developed. Geometry-selective acylation of tetrasubstituted alkendiols and highly enantioselective asymmetric desymmterization of σ-symmetric long-chain alkane diols were also developed by organocatalysis.
|
