2011 Fiscal Year Final Research Report
Research on Development of Biologically Functional Molecules Aiming at DrugDiscovery: An Approach by Creative Organic Syntheses
| Project/Area Number |
21249002
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DOHI Toshifumi 立命館大学, 薬学部, 助教 (50423116)
FUJIOKA Hiromichi 大阪大学, 薬学研究科, 教授 (10173410)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 創薬合成 / 生物活性物 / 生体機能分子 / 環境調和 / 立体選択的合成 / 高活性化学種 / 有機反応剤 / 有機触媒 |
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| Research Abstract |
We have advanced our creative methods to environmentally friendly and sustainable synthesis of a series of natural products which have complicated and high dimensional structures showing interesting biological activities but occur only in small amounts in nature, and also living body-functioned molecules for the purpose of obtaining many useful compounds for drug development. Using these newly synthesized compounds, research toward creation of novel medicinal target based on new mechanisms has been performed in collaboration with other research groups and institutes having original drug evaluation systems. Furthermore, we also developed a metal-free direct synthesis of the organic materials using our synthetic methods.
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