2011 Fiscal Year Final Research Report
Structure, function and physiological significance of vesicular nucleotide transporter(VNUT)
| Project/Area Number |
21249005
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生化学 / 化学伝達 / トランスポーター / プリン作動性 / ATP / ノックアウトマウス / 神経 / アストロサイト |
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| Research Abstract |
ATP is a major chemical transmitter in purinergic signal transmission, which distributes throughout the body and plays an essential role in varuous physiological and pathological processes such as the reception of chemical senses and pains, neuroregeneration, platelet aggregation, inflammation. Before secretion, ATP is stored in the secretory vesicles. Vesicular nucleotide transporter(VNUT) is responsible for vesicular storage of nucleotide and thus plays an essential role in the purinergic chemial transmission. This study revealed sturucturral and functional relationship, and physiological significance of VNUT. In particular we established(1) potent and reversible modifiers of VNUT and(2) knockout mice. Using these two tools, we can control purinergic chemical transmisson in vitro and in vivo.
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