2011 Fiscal Year Final Research Report
Morphogenetic regulation through D-serine/serine racemase
| Project/Area Number |
21249009
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Keio University |
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Principal Investigator |
AISO Sadakazu 慶應義塾大学, 医学部, 教授 (60138013)
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| Co-Investigator(Renkei-kenkyūsha) |
SASABE Jumpei 慶應義塾大学, 医学部, 助教 (10398612)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 発生学 / 形態形成学 |
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| Research Abstract |
This study aims at elucidating physiological and pathophysiological significances of D-serine regulation in the central nervous system. In association with its physiological roles, we found D-serine-degrading enzyme, D-amino acid oxidase, distributed to a motoneuronal input and maintain D-serine at a low level in the region. As a pathophysiological approach, we found D-amino acid oxidase controls motoneuron degeneration and loss of its activity increases spinal D-serine level in amyotrophic lateral sclerosis. Independently, we found that streptozotocin-induced type1 diabetes increases hippocampal D-serine through loss of insulin.
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