2011 Fiscal Year Final Research Report
Regulation of immune cell responses by heme
| Project/Area Number |
21249014
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MOTOHASHI Hozumi 東北大学, 大学院・医学系研究科, 准教授 (00282351)
MUTO Akihiko 東北大学, 大学院・医学系研究科, 准教授 (80343292)
KATOH Yasutake 東北大学, 大学院・医学系研究科, 助教 (40397914)
MURAYAMA Kazutaka 東北大学, 大学院・医工学研究科, 准教授 (40400452)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 遺伝子 / 免疫学 / 発生分化 / 蛋白質 / ストレス |
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| Research Abstract |
The transcription factor Bach2 is required in B cells for the antibody class switch DNA recombination and somatic hypermutation. In this project, we have established that the prosthetic group heme binds directly to Bach2 to inhibits its DNA binding activity and to induce rapid turnover within cells. We also identified a domain-like structure within Bach2 that mediates the regulation by heme. Three cysteine residues within this domain were critical for the heme-Bach2 interaction. These results suggest that heme functions as a signaling molecule in B cells to regulate immune responses.
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Research Products
(7 results)
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[Journal Article] Heme regulates B cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach22011
Author(s)
Watanabe-Matsui, M., Muto, A., Matsui, T., Itoh-Nakadai, A., Nakajima, O., Murayama, K., Yamamoto, M., Ikeda-Saito, M., Igarashi, K.
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Journal Title
Blood
Volume: 117巻
Pages: 5438-5448
Peer Reviewed
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[Journal Article] Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch2010
Author(s)
Muto, A., Ochiai, K., Kimura, Y., Itoh-Nakadai, A., Calame, K. L., Ikebe, D., Tashiro, S. and Igarashi, K.
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Journal Title
EMBO J.
Volume: 29巻
Pages: 4048-4061
Peer Reviewed
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