2011 Fiscal Year Final Research Report
Regulation of signaling network and cellular responses by Wnt
Project/Area Number |
21249017
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Osaka University |
Principal Investigator |
KIKUCHI Akira 大阪大学, 医学系研究科, 教授 (10204827)
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Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hideki 大阪大学, 大学院・医学系研究科, 准教授 (20372691)
SATO Akira 大阪大学, 大学院・医学系研究科, 助教 (70464302)
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Project Period (FY) |
2009 – 2011
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Keywords | Wnt / シグナル伝達 / 受容体 / エンドサイトーシス / 極性 / がん / 転移 |
Research Abstract |
In this study we analyzed the molecular mechanism of the regulation of Wnt signaling and the pathogenesis of diseases due to its abnormalities. The following points were clarified.(1) The selective activation of Wnt signaling was regulated by receptor-mediated endocytosis.(2) Wnt5a regulated cell migration through the organization of microtubule stability by the binding of Dvl and APC.(3) Overexpression of Wnt5a promoted aggressiveness of gastric cancer through the induction of laminin 2.
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[Journal Article] An Wnt5a-antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis2012
Author(s)
Hanaki, H., Yamamoto, H., Sakane, H., Matsumoto, S., Ohdan, H., Sato, A., and Kikuchi, A
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Journal Title
Mol. Cancer Ther
Volume: 11
Pages: 298-307
Peer Reviewed
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[Journal Article] Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates2011
Author(s)
Miyamoto, T., Porazinski, S., Wang, H., Borovina, A., Ciruna, B., Shimizu, A., Kajii, T., Kikuchi, A., Furutani-Seiki, M., and Matsuura, S
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Journal Title
Hum. Mol. Genet
Volume: 20
Pages: 2058-2070
Peer Reviewed
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[Journal Article] The transmembrane protein Waif1/ 5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization2011
Author(s)
Kagermeier-Schenk, B., Wehner, D., Ozhan-Kizil, G., Yamamoto, H., Jian Li, Kirchner, K., Hoffmann, C., Stern, P., Kikuchi, A., Schambony, A., and Weidinger, G
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Journal Title
Dev. Cell
Volume: 21
Pages: 1129-1143
Peer Reviewed
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[Journal Article] MMP-10/ Stromelysin-2 Promotes Invasion of Head and Neck Cancer2011
Author(s)
Deraz, E. M., Kudo, Y., Yoshida, M., Obayashi, M., Tsunematsu, T., Tani, H., Siriwardena, S., Keikhaee, M. R., Qi, G., Iizuka, S., Ogawa, I., Campisi, G., Lo Muzio, L., Abiko, Y., Kikuchi, A., Takata, T
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Journal Title
PLoS ONE
Volume: 6
Pages: e25438
Peer Reviewed
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[Journal Article] Ror2/ Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization2010
Author(s)
Nishida, M., Itsukushima, S., Nomachi, A., Endo, M., Wang, Z., Inaba, D., Qiao, S., Takada, S., Kikuchi, A., and Minami, Y
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Journal Title
Mol. Cell. Biol
Volume: 30
Pages: 3610-3619
Peer Reviewed
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[Journal Article] Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase2010
Author(s)
Yamamoto, H., Oue, N., Sato, A., Hasegawa, Y., Matsubara, A., Yamamoto, H., Yasui, W., and Kikuch, A
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Journal Title
Oncogene
Volume: 29
Pages: 2036-2046
Peer Reviewed
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[Journal Article] Laminin・2 mediates Wnt5a-induced invasion of gastric cancer cells2009
Author(s)
Yamamoto, H., Kitadai, . Y., Yamamoto, H., Oue, N., Ohdan, H., Yasui, W., and Kikuchi, A
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Journal Title
Gastroenterology
Volume: 137
Pages: 242-252
Peer Reviewed
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[Journal Article] CHD8 suppreses p53-mediated apoptosis through histone H1 recruotment during early embryogenesis2009
Author(s)
Nishiyama, M., Oshikawa, K., Tukada, Y., Nakagawa, T., Iemura S., Natsume, T., Fan Y., Kikuchi, A., Skoultchi, A. I., and Nakayama, K
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Journal Title
Nat. Cell Biol
Volume: 11
Pages: 172-182
Peer Reviewed
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[Journal Article] Wnt-Ryk signaling mediates axon growth inhibition andlimits functional recovery after spinal cord injury2009
Author(s)
Miyashita, T., Koda, M., Kitajo, K., Yamazaki, M., Takahashi, K., Kikuchi, A. and Yamashita, T
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Journal Title
J Neurotrauma
Volume: 26
Pages: 955-964
Peer Reviewed
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