2011 Fiscal Year Final Research Report
Mother-to-child kinetics and exposure assessment model for co-exposure to methylmercury and POPs during perinatal periods
| Project/Area Number |
21249039
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Tohoku University |
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Principal Investigator |
SATOH Hiroshi 東北大学, 大学院・医学系研究科, 名誉教授 (40125571)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAI Kunihiko 東北大学, 大学院・医学系研究科, 教授 (00291336)
KUROKAWA Naoyuki 東北大学, 大学院・医学系研究科, 助教 (30431505)
TATSUTA Nozomi 東北大学, 大学院・医学系研究科, 助手 (40547709)
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| Research Collaborator |
IWAI Miyuki (SHIMADA Miyuki) 東北大学, 大学院・医学系研究科, 日本学術振興会特別研究員
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| Project Period (FY) |
2009 – 2011
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| Keywords | 環境保健 / トキシコキネティクス |
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| Research Abstract |
Methylmercury (MeHg)and persistent organic pollutantspoly (POPs)such as PCBs and DDTs are environmentally persistent neurodevelopmental toxicants. They can be transferred from the mother to the fetus via palacenta and to the infant via breastfeeding. The main sources of the exposures to MeHg and POPs are food, particularly the consumption of fish and fish products in Japan. We previously carried out an animal experiment to examine the effect of co-exposure to MeHg and POPs on mother-to-child kinetics using mice and guinea pig. We administered MeHg and POPs using whale oil for POPs exposure. p, p'-DDE-d8 added was similarly accumulated and, d8 provided a useful index for predicting the distribution of DDTs. We observed negative effects on eye opening and open field test in group of mice of high contaminated POPs oil.
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[Presentation] Co-exposure to methylmercury and PCBs increases accumulation of PCBs in the brains of offspring mice2010
Author(s)
Shimada, M., T. Nakamura, N. Sugawara, K. Yaginuma, N. Tatsuta, N. Kurokawa, K. Nakai, H. Satoh
Organizer
30th International Symposium on Halogenated Persistent Organic Pollutants
Place of Presentation
San Antonio, Texas, USA
Year and Date
20100912-17
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