2012 Fiscal Year Final Research Report
Development of micrRNA-targeting cancer prevention
| Project/Area Number |
21249042
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SAKAI Toshiyuki 京都府立医科大学, 医学研究科, 教授 (20186993)
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| Co-Investigator(Kenkyū-buntansha) |
SOWA Yoshihiro 京都府立医科大学, 医学研究科, 准教授 (70315935)
YOGOSAWA Shingo 京都府立医科大学, 医学研究科, 助教 (70381936)
TOMOSUGI Mano (HORINAKA Mano) 京都府立医科大学, 医学研究科, 助教 (80512037)
友杉 充宏 京都府立医科大学, 医学部, 研究員 (60533429)
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| Project Period (FY) |
2009 – 2012
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| Keywords | フラボン / miR-34a / G1 期停止 / E2F |
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| Research Abstract |
Flavone, which is known as a cancer preventive agent, induced growth inhibiton, G1 arrest and the decrease of the E2F1 and E2F3, which act for G1/S progression, in prostate cancer cells. Flavone also induced miR-34a, which regulates the expression of E2F1 and E2F3. Furthermore, the inhibition of miR-34a suppressed the G1 arrest and decrease of the E2F1 and E2F3 by the treatment of flavone. These results raise a possibility that cancer preventive agents inhibit the cell proliferation through the in duction of microRNAs.
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[Journal Article] Histone deacetylase inhibitors and 15-deoxy-・12,14-prostaglandin J2 synergistically induce apoptosis2010
Author(s)
Koyama M, Izutani Y, Goda AE, Matsui TA, Horinaka M, Tomosugi M, Fujiwara J, Nakamura Y, Wakada M, Yogosawa S, Sowa Y, Sakai T
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Journal Title
Clin Cancer Res.
Volume: Vol. 16、No. 8
Pages: 2320-2332
DOI
Peer Reviewed
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