2013 Fiscal Year Final Research Report
Studies for the detail mechanisms of depression onset and the development of novel antidepressants based on "the Wakan-yaku, Sino-Japanese traditional medicine, theory"
| Project/Area Number |
21249047
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
TOHDA Michihisa 富山大学, 和漢医薬学総合研究所, 准教授 (20207525)
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| Co-Investigator(Kenkyū-buntansha) |
KOMATSU Katsuko 富山大学, 和漢医薬学総合研究所, 教授 (50225570)
NAMIKI Takao 千葉大学, 医学(系)研究科(研究院), 准教授 (20312001)
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Hirozou 北聖病院(富山市), 医師 (40313598)
TOHDA Chihiro 富山大学, 和漢医薬学総合研究所, 准教授 (10272931)
TEI Miwa 北里大学, 北里生命科学研究所, 特任助教 (50464029)
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| Research Collaborator |
YOKAWA Takashi BioView 社, 代表取締役
MONRUDEE Sukma シラパコーン大学 (タイ国), 薬学部, 助教
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | 和漢薬 / 統合薬理学 / MRI / 病態モデル / 遺伝子発現 / 機能性精神疾患 / 3D-HPLC / テーラーメード医療 |
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| Research Abstract |
The Wakan-yaku is systematized medical care that has been practiced for several hundred years in Japan. Based on the theories of Wakan-yaku and using various Wakan-yaku prescriptions for depression treatment, the experimental studies for 1) novel-classification of depressive disorders, 2) establishment of highly effective drug treatment including the Wakan-yaku prescriptions, and 3) to supply of novel basic knowledge for development of new antidepressants were carried out. The following results were obtained; Wakan-yaku effects in the brain of drug-sensitive/-insensitive human and depression-model mice by image analytical method (MRI), the integrated viewpoint of the action mechanism using the model animal, identification and the significance of genes which changes the expression by Wakan-yaku or the constitutions in cultured cells, and the bioassay of active compounds by using the combined methods of electrophysiological technique with 3D-HPLC analysis/purification.
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