2011 Fiscal Year Final Research Report
Investigation of intestinal macrophage in contribution to gut immune homeostasis and its disruption in Crohn's disease
| Project/Area Number |
21249048
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Takanori 慶應義塾大学, 医学部, 准教授 (40245478)
HISAMATSU Tadakazu 慶應義塾大学, 医学部, 講師 (60255437)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 炎症性腸疾患 / マクロファージ / 腸内細菌 / NK細胞 / サイトカイン |
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| Research Abstract |
We identified that resident intestinal macrophages include a subpopulation of MCP-1 dependent CCR2+IL-10 producing M. which contributes to gut homeostasis. In IL-10 KO mice, we showed intracellular signaling after phagocytosis is important for production of proinflammatory cytokines by intestinal macrophages. In human Crohn's disease, we demonstrated that intestinal macrophages interact with mucosal NK cells and contribute to enhance of Th1 immune response. Furthermore, our studies demonstrated that bile acids can induce differentiation into IL-12 hypo-producing DCs. Thus, conditioning and regulation of innate immune cells such as macrophages and dendritic cells(DCs) have a potential to be a therapeutic target of Crohn's disease.
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Research Products
(32 results)
