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2009 Fiscal Year Annual Research Report

ヒト化アクティブモデルマウスによる水疱性類天疱瘡の発症機序解明と新規治療法開発

Research Project

Project/Area Number 21249063
Research InstitutionHokkaido University

Principal Investigator

清水 宏  Hokkaido University, 大学院・医学研究科, 教授 (00146672)

Co-Investigator(Kenkyū-buntansha) 芝木 晃彦  北海道大学, 大学病院, 講師 (40291231)
秋山 真志  北海道大学, 大学院・医学研究科, 准教授 (60222551)
阿部 理一郎  北海道大学, 大学病院, 講師 (60344511)
西村 栄美  東京医科歯科大学, 難治疾患研究所, 教授 (70396331)
Keywords自己免疫性疾患
Research Abstract

1)17型コラーゲンヒト化免疫不全マウスの作成
水疱性類天疱瘡(BP)のヒト化アクティブマウスモデル樹立のため、17型コラーゲン(COL17)ヒト化マウスと免疫不全マウスを交配し、COL17ヒト化免疫不全マウスを作成中である。COL17ヒト化マウスをRag2ノックアウトマウスと交配させて、COL17ヒト化Rag2ノックアウトマウスを得ることができた。また、既存のCOL17ヒト化マウスはC57BL/6をバックグラウンドとしているため、BALB/c由来の免疫不全マウスと直接交配できなかった。このため、まずCOL17ヒト化マウスのバッククロスを繰り返すことでBALB/cのCOL17ヒト化マウスの作成に成功した。
2)免疫不全マウスへの正常人末梢リンパ球移植
COL17ヒト化免疫不全マウスの作成に成功した場合、これらのマウスに対してBP患者由来の末梢血リンパ球を移植し、持続的にBPの臨床像を再現できるBPヒト化アクティブマウスモデルを樹立する予定である。本年度では免疫不全マウスの一つであるNOGマウスに対して、正常人由来末梢血リンパ球を移植することにより、リンパ球の生着が確認できるかどうか検討を行った。移植後4週間までの時点ではヒト由来リンパ球の生着は良好であった。しかしながら、移植後8週間の時点ではヒト由来リンパ球の数の減少とともに、マウスの脱毛や紅斑などの症状があらわれるようになり、移植片対宿主病の表現型の発現と考えられた。

  • Research Products

    (146 results)

All 2010 2009 Other

All Journal Article (63 results) (of which Peer Reviewed: 63 results) Presentation (75 results) Book (8 results)

  • [Journal Article] Blockade of autoantibody-initiated tissue damage by using recombinant fab antibody fragments against pathogenic autoantigen2010

    • Author(s)
      Wang G, Ujiie H, Shibaki A, Nishie W, Tateishi Y, Kikuchi K, Li Q, McMillan JR, Morioka H, Sawamura D, Nakamura H, Shimizu H
    • Journal Title

      Am J Pathol 176

      Pages: 914-925

    • Peer Reviewed
  • [Journal Article] A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen2010

    • Author(s)
      Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Moriuchi R, Qiao H, Nakamura H, Akiyama M, Shimizu H
    • Journal Title

      J Immunol 184

      Pages: 2166-2174

    • Peer Reviewed
  • [Journal Article] Successful treatment of nail lichen planus with topical tacrolimus2010

    • Author(s)
      Ujiie H, Shibaki A, Akiyama M, Shimizu H
    • Journal Title

      Acta Derm Venereol 90

      Pages: 218-219

    • Peer Reviewed
  • [Journal Article] Hereditary benign telangiectasia : two families with punctate telangiectasias surrounded by anemic halos2010

    • Author(s)
      Ujiie H, Kodama K, Akiyama M, Shimizu H
    • Journal Title

      Arch Dermatol 146

      Pages: 98-99

    • Peer Reviewed
  • [Journal Article] Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome2010

    • Author(s)
      Ujihara M, Nakajima K, Yamamoto M, Teraishi M, Uchida Y, Akiyama M, Shimizu H, Sano S
    • Journal Title

      J Dermatol Sci 57

      Pages: 102-107

    • Peer Reviewed
  • [Journal Article] Response of intractable skin ulcers in recessive dystrophic epidermolysis bullosa patients to an allogeneic cultured dermal substitute2010

    • Author(s)
      Natsuga K, Sawamura D, Goto M, Homma E, Goto-Ohguchi Y, Aoyagi S, Akiyama M, Kuroyanagi Y, Shimizu H
    • Journal Title

      Acta Derm Venereol 90

      Pages: 165-169

    • Peer Reviewed
  • [Journal Article] Circulating IgA and IgE autoantibodies in antilaminin-332 mucous membrane pemphigoid2010

    • Author(s)
      Natsuga K, Nishie W, Shinkuma S, Moriuchi R, Shibata M, Nishimura M, Hashimoto T, Shimizu H
    • Journal Title

      Br J Dermatol 162

      Pages: 513-517

    • Peer Reviewed
  • [Journal Article] Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex2010

    • Author(s)
      Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Bruckner-Tuderman L, Shimizu H
    • Journal Title

      Hum Mutat 31

      Pages: 308-316

    • Peer Reviewed
  • [Journal Article] Controlling the histological margin for non-melanoma skin cancer conveniently using a double-bladed scalpel2010

    • Author(s)
      Aoyagi S, Hata H, Homma E, Shimizu H
    • Journal Title

      J Surg Oncol 101

      Pages: 175-179

    • Peer Reviewed
  • [Journal Article] CD30-positive primary cutaneous anaplastic large-cell lymphoma and definite squamous cell carcinoma2009

    • Author(s)
      Yanagi T, Shimizu T, Kodama K, Nemoto-Hasebe I, Kasai M, Shimizu H
    • Journal Title

      Clin Exp Dermatol 34

      Pages: e293-294

    • Peer Reviewed
  • [Journal Article] Primary cutaneous CD30+ anaplastic large-cell lymphoma with generalized skin involvement and involvement of one peripheral lymph node, successfully treated with low-dose oral etoposide2009

    • Author(s)
      Yamane N, Kato N, Nishimura M, Ito M, Yanagi T, Osawa R
    • Journal Title

      Clin Exp Dermatol 34

      Pages: e56-59

    • Peer Reviewed
  • [Journal Article] Bloody nipple discharge in an infant2009

    • Author(s)
      Ujiie H, Akiyama M, Osawa R, Shida S, Aoyagi S, Shimizu H
    • Journal Title

      Arch Dermatol 145

      Pages: 1068-1069

    • Peer Reviewed
  • [Journal Article] Glycosylation specific for adhesion molecules in epidermis and its receptor revealed by glycoform-focused reverse genomics2009

    • Author(s)
      Uematsu R, Shinohara Y, Nakagawa H, Kurogochi M, Furukawa J, Miura Y, Akiyama M, Shimizu H, Nishimura S
    • Journal Title

      Mol Cell Proteomics 8

      Pages: 232-244

    • Peer Reviewed
  • [Journal Article] Embryonic hair follicle fate change by augmented{beta}-catenin through Shh and Bmp signaling2009

    • Author(s)
      Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, Taketo MM, Nakagata N, Tsukiyama T, Yamaguchi TP, Birchmeier W, Kato S, Yamada G
    • Journal Title

      Development 136

      Pages: 367-372

    • Peer Reviewed
  • [Journal Article] Pemphigus foliaceus associated with oesophageal cancer2009

    • Author(s)
      Shinkuma S, Akiyama M, Torii-Saito N, Natsuga K, Tateishi Y, Ito K, Hirota J, Shimizu Y, Shichinohe T, Shimizu H
    • Journal Title

      J Eur Acad Dermatol Venereol 23

      Pages: 473-474

    • Peer Reviewed
  • [Journal Article] Secondary syphilis mimicking warts in an HIV-positive patient2009

    • Author(s)
      Shinkuma S, Abe R, Nishimura M, Natsuga K, Fujita Y, Nomura T, Nishie W, Shimizu H
    • Journal Title

      Sex Transm Infect 85

      Pages: 484

    • Peer Reviewed
  • [Journal Article] ABCA12 is a major causative gene for non-bullous congenital ichthyosiform erythroderma2009

    • Author(s)
      Sakai K, Akiyama M, Yanagi T, McMillan JR, Suzuki T, Tsukamoto K, Sugiyama H, Hatano Y, Hayashitani M, Takamori K, Nakashima K, Shimizu H
    • Journal Title

      J Invest Dermatol 129

      Pages: 2306-2309

    • Peer Reviewed
  • [Journal Article] Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38MAPK-dependent migration and cell signaling2009

    • Author(s)
      Qiao H, Shibaki A, Long HA, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H, McMillan JR
    • Journal Title

      J Invest Dermatol 129

      Pages: 2288-2295

    • Peer Reviewed
  • [Journal Article] A novel PTPN11 missense mutation in a patient with LEOPARD syndrome2009

    • Author(s)
      Osawa R, Akiyama M, Yamanaka Y, Ujiie H, Nemoto-Hasebe I, Takeda A, Yanagi T, Shimizu H
    • Journal Title

      Br J Dermatol 161

      Pages: 1202-1204

    • Peer Reviewed
  • [Journal Article] Disseminated cutaneous Mycobacterium kansasii infection in an patient infected with the human immunodeficiency virus2009

    • Author(s)
      Nomura Y, Nishie W, Shibaki A, Ibata M, Shimizu H
    • Journal Title

      Clin Exp Dermatol 34

      Pages: 625-626

    • Peer Reviewed
  • [Journal Article] Progressive Refractory Ulcer of the Nipple : A Quiz2009

    • Author(s)
      Nomura Y, Akiyama M, Nishie W, SHimizu H
    • Journal Title

      Acta Derm Venereol 89

      Pages: 445-447

    • Peer Reviewed
  • [Journal Article] Widespread keratosis follicularis squamosa2009

    • Author(s)
      Nomura Y, Abe M, Natsuga K, Moriuchi R, Kawasaki H, Mayuzumi M, Yasuoka A, Shimizu H
    • Journal Title

      Clin Exp Dermatol 34

      Pages: 519-520

    • Peer Reviewed
  • [Journal Article] Prevalent and rare mutations in the gene encoding filaggrin in Japanese patients with ichthyosis vulgaris and atopic dermatitis2009

    • Author(s)
      Nomura T, Akiyama M, Sandilands A, Nemoto-Hasebe I, Sakai K, Nagasaki A, Palmer CN, Smith FJ, McLean WH, Shimizu H
    • Journal Title

      J Invest Dermatol 129

      Pages: 1302-1305

    • Peer Reviewed
  • [Journal Article] A novel humanized neonatal autoimmune blistering skin disease model induced by maternally transferred antibodies2009

    • Author(s)
      Nishie W, Sawamura D, Natsuga K, Shinkuma S, Goto M, Shibaki A, Ujiie H, Olasz E, Yancey KB, Shimizu H
    • Journal Title

      J Immunol 183

      Pages: 4088-4093

    • Peer Reviewed
  • [Journal Article] FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema2009

    • Author(s)
      Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean WH, Shimizu H
    • Journal Title

      Br J Dermatol 161

      Pages: 1387-1390

    • Peer Reviewed
  • [Journal Article] Clinical severity correlates with impaired barrier in filaggrin-related eczema2009

    • Author(s)
      Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean WH, Shimizu H
    • Journal Title

      J Invest Dermatol 129

      Pages: 682-689

    • Peer Reviewed
  • [Journal Article] Novel mutation p.Gly59Arg in GJB6 encoding connexin 30 underlies plamoplantar keratoderma with pseudoainhum, knuckle pads and hearing loss2009

    • Author(s)
      Nemoto-Hasebe I, Akiyama M, Kudo S, Ishiko A, Tanaka A, Arita K, Shimizu H
    • Journal Title

      Br J Dermatol 161

      Pages: 452-455

    • Peer Reviewed
  • [Journal Article] Animal models of epidermolysis bullosa2009

    • Author(s)
      Natsuga K, Shinkuma S, Nishie W, Shimizu H
    • Journal Title

      Dermatol Clin 28

      Pages: 137-142

    • Peer Reviewed
  • [Journal Article] Epidermolysis bullosa(EB)-diagnosis and therapy2009

    • Author(s)
      McMillan JR, Long HA, Akiyama M, Shimizu H, Kimble RM
    • Journal Title

      Wound Practice and Research 17

      Pages: 62-70

    • Peer Reviewed
  • [Journal Article] Current advances in gene therapy for the treatment of genodermatoses2009

    • Author(s)
      Long HA, McMillan JR, Qiao H, Akiyama M, Shimizu H
    • Journal Title

      Curr Gene Ther 9

      Pages: 487-494

    • Peer Reviewed
  • [Journal Article] Spontaneous giant aneurysm of the superficial temporal artery : case report2009

    • Author(s)
      Kawabori M, Kuroda S, Nakayama N, Kenmotsu Y, Shimizu H, Tanino M, Iwasaki Y
    • Journal Title

      Neurol Med Chir 49

      Pages: 198-201

    • Peer Reviewed
  • [Journal Article] Morphological and genetic analysis of steatocystoma multiplex in an Asian family with pachyonychia congenita type 2 harbouring a KRT17 missense mutation2009

    • Author(s)
      Kanda M, Natsuga K, Nishie W, Akiyama M, Nagasaki A, Shimizu T, Shimizu H
    • Journal Title

      Br J Dermatol 160

      Pages: 465-468

    • Peer Reviewed
  • [Journal Article] Keratinocyte-/fibroblast-targeted rescue of Co17a1-disrupted mice and generation of an exact dystrophic epidermolysis bullosa model using a-human COL7A1 mutation2009

    • Author(s)
      Ito K, Sawamura D, Goto M, Nakamura H, Nishie W, Sakai K, Natsuga K, Shinkuma S, Shibaki A, Uitto J, Denton CP, Nakajima O, Akiyama M, Shimizu H
    • Journal Title

      Am J Pathol 175

      Pages: 2508-2517

    • Peer Reviewed
  • [Journal Article] Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation2009

    • Author(s)
      Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E, Masunaga T, Shimizu H, Nishimura EK
    • Journal Title

      Cell 137

      Pages: 1088-1099

    • Peer Reviewed
  • [Journal Article] Scleroedema adultorum associated with sarcoidosis2009

    • Author(s)
      Inokuma D, Sawamura D, Shibaki A, Abe R, Shimizu H
    • Journal Title

      Clin Exp Dermatol 34

      Pages: e428-429

    • Peer Reviewed
  • [Journal Article] Autoantibodies against type XVII collagen C-terminal domain in patient with bullous pemphigoid associated with psoriasis vulgaris2009

    • Author(s)
      Inokuma D, Kodama K, Natsuga K, Kasai M, Abe M, Nishie W, Abe R, Hashimoto T, Shimizu H
    • Journal Title

      Br J Dermatol 160

      Pages: 451-454

    • Peer Reviewed
  • [Journal Article] Bowen's disease of the nail matrix presenting as melanonychia : detection of human papillomavirus type 562009

    • Author(s)
      Inokuma D, Aoyagi S, Saito N, Iitani MM, Homma E, Hamasaka K, Shimizu H
    • Journal Title

      Acta Derm Venereol 89

      Pages: 638-639

    • Peer Reviewed
  • [Journal Article] Birt-Hogg-Dube syndrome with clear-cell and oncocytic renal tumour and trichoblastoma associated with a novel FLCN mutation2009

    • Author(s)
      Imada K, Dainichi T, Yokomizo A, Tsunoda T, Song YH, Nagasaki A, Sawamura D, Nishie W, Shimizu H, Fukagawa S, Urabe K, Furue M, Hashimoto T, Naito S
    • Journal Title

      Br J Dermatol 160

      Pages: 1350-1353

    • Peer Reviewed
  • [Journal Article] Analysis of Taiwanese ichthyosis vulgaris families further demonstrates differences in FLG mutations between European and Asian populations2009

    • Author(s)
      Hsu CK, Akiyama M, Nemoto-Hasebe I, Nomura T, Sandilands A, Chao SC, Lee JY, Sheu HM, McLean WH, Shimizu H
    • Journal Title

      Br J Dermatol 161

      Pages: 448-451

    • Peer Reviewed
  • [Journal Article] Deficient deletion of apoptotic cells by macrophage migration inhibitory factor(MIF)overexpression accelerates photocarcinogenesis2009

    • Author(s)
      Honda A, Abe R, Yoshihisa Y, Makino T, Matsunaga K, Nishihira J, Shimizu H, Shimizu T
    • Journal Title

      Carcinogenesis 30

      Pages: 1597-1605

    • Peer Reviewed
  • [Journal Article] Melanonychia caused by Stenotrophomonas maltophilia2009

    • Author(s)
      Hamasaka E, Akiyama M, Hala H, Aoyagi S, Shimizu H
    • Journal Title

      Clin Exp Dermatol 34

      Pages: 242-243

    • Peer Reviewed
  • [Journal Article] DNA vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine models2009

    • Author(s)
      Hamasaka A, Abe R, Koyama Y, Yoshioka N, Fujita Y, Hoshina D, Sasaki M, Hirasawa T, Onodera S, Ohshima S, Leng L, Bucala R, Nishihira J, Shimizu T, Shimizu H
    • Journal Title

      J Allergy Clin Immunol 124

      Pages: 90-99

    • Peer Reviewed
  • [Journal Article] A severe and refractory case of anti-p200 pemphigoid resulting in multiple skin ulcers and scar formation2009

    • Author(s)
      Goto-Ohguchi Y, Nishie W, Akiyama M, Tateishi Y, Aoyagi S, Tsuji-Abe Y, Sawamura D, Ishii N, Hashimoto T, Shimizu H
    • Journal Title

      Dermatology 218

      Pages: 265-270

    • Peer Reviewed
  • [Journal Article] Immunological reconstitution after autologous hematopoietic stem cell transplantation in patients with systemic sclerosis : relationship between clinical benefits and intensity of immunosuppression2009

    • Author(s)
      Bohgaki T, Atsumi T, Bohgaki M, Furusaki A, Kondo M, Sato-Matsumura KC, Abe R, Kataoka H, Horita T, Yasuda S, Amasaki Y, Nishio M, Sawada K, Shimizu H, Koike T
    • Journal Title

      J Rheumatol 36

      Pages: 1240-1248

    • Peer Reviewed
  • [Journal Article] Higher density of label-retaining cells in gingival epithelium2009

    • Author(s)
      Asaka T, Akiyama M, Kitagawa Y, Shimizu H
    • Journal Title

      J Dermatol Sci 55

      Pages: 132-134

    • Peer Reviewed
  • [Journal Article] Type XVII collagen is a key player in tooth enamel formation2009

    • Author(s)
      Asaka T, Akiyama M, Domon T, Nishie W, Natsuga K, Fujita Y, Abe R, Kitagawa Y, Shimizu H
    • Journal Title

      Am J Pathol 174

      Pages: 91-100

    • Peer Reviewed
  • [Journal Article] A novel OSMR mutation in familial primary localized cutaneous amyloidosis in a Japanese family2009

    • Author(s)
      Arita K, Abe R, Baba K, McGrath JA, Akiyama M, Shimizu H
    • Journal Title

      J Dermatol Sci 55

      Pages: 64-65

    • Peer Reviewed
  • [Journal Article] Usefulness of real-time tissue elastography for detecting lymph-node metastases in squamous cell carcinoma2009

    • Author(s)
      Aoyagi S, Izumi K, Hata H, Kawasaki H, Shimizu H
    • Journal Title

      Clin Exp Dermatol 34

      Pages: e744-e747

    • Peer Reviewed
  • [Journal Article] Squamous cell carcinoma of the auricle with rhabdoid features2009

    • Author(s)
      Aoyagi S, Hata H, Iitani MM, Homma E, Inokuma D, Shimizu H
    • Journal Title

      J Cutan Pathol 36

      Pages: 919-921

    • Peer Reviewed
  • [Journal Article] Desmogleinl and BP 180 ELISA indexes correlating with disease activity in a patient with coexisting pemphigus foliaceus and bullous pemphigoid2009

    • Author(s)
      Ando S, Sato-Matsumura KC, Kasai M, Nemoto-Hasebe I, Hoshina D, Ohyama B, Hashimoto T, Shimuzu H
    • Journal Title

      Clin Exp Dermatol 34

      Pages: e995-996

    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells are not the origin of the cancer stem cells in ultraviolet-induced skin cancer2009

    • Author(s)
      Ando S, Abe R, Sasaki M, Murata J, Inokuma D, Shimizu H
    • Journal Title

      Am J Pathol 174

      Pages: 595-601

    • Peer Reviewed
  • [Journal Article] A randomized double-blind trial of intravenous immunoglobulin for pemphigus2009

    • Author(s)
      Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K, Aiba S, Kaneko F, Izaki S, Tamaki K, Ikezawa Z, Takigawa M, Seishima M, Tanaka T, Miyachi Y, Katayama I, Horiguchi Y, Miyagawa S, Furukawa F, Iwatsuki K, Hide M, Tokura Y, Furue M, Hashimoto T, Ihn H, Fujiwara S, Nishikawa T, Ogawa H, Kitajima Y, Hashimoto K
    • Journal Title

      J Am Acad Dermatol 60

      Pages: 595-603

    • Peer Reviewed
  • [Journal Article] Conradi-Hunermann-Happle syndrome with abnormal lamellar granule contents2009

    • Author(s)
      Akiyama M, Sakai K, Hayasaka K, Tabata N, Yamada M, Ujiie H, Shibaki A, Shimizu H
    • Journal Title

      Br J Dermatol 160

      Pages: 1335-1337

    • Peer Reviewed
  • [Journal Article] Granulysin as a marker for early diagnosis of the Stevens-Johnson syndrome2009

    • Author(s)
      Abe R, Yoshioka N, Murata J, Fujita Y, Shimizu H
    • Journal Title

      Ann Intern Med 151

      Pages: 514-515

    • Peer Reviewed
  • [Journal Article] Revised nomenclature and classification of inherited ichthyoses : Results of the First Ichthyosis

    • Author(s)
      Vinzenz O, Gianluca T, Akiyama M, Claudine B-B, Christine B, Emmanuelle B, Philippe C, John JD, Peter E, Judith F, Philip F, Michal G, John H, Hashimoto T, Ingrid H, Hans CH, Daniel H, Alain H, Ishida-Yamamoto A, Withold KJ, Sancy L, Irene L, Juliette M-H, Leonhard M, Fanny M-P, Amy SP, Gabriele R, Matthias S, Shimizu H, Eli S, Maurice vS, Alain T, Jorge RT, Pierre V, Anders V, Mary W, Heiko T
    • Journal Title

      J Am Acad Dermatol (in press)

    • Peer Reviewed
  • [Journal Article] Three-base deletion mutation c. 120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease

    • Author(s)
      Tsuruta D, Akiyama M, Ishida-Yamamoto A, Imanishi H, Mizuno N, Sowa J, Kobayashi H, Ishii M, Kurokawa I, Shimizu H
    • Journal Title

      Br J Dermatol (in press)

    • Peer Reviewed
  • [Journal Article] An Indian family with Sjogren-Larsson syndrome caused by a novel ALDH3A2 mutation

    • Author(s)
      Sakai K, Akiyama M, Yanagi T, Nampoothiri S, Mampilly T, V S, Shimizu H
    • Journal Title

      Int J Dermatol (in press)

    • Peer Reviewed
  • [Journal Article] Extremely severe palmoplantar hyperkeratosis in a generalized epidermolytic hyperkeratosis patient with a keratin 1 gene mutation

    • Author(s)
      Osawa R, Akiyama M, Izumi K, Ujiie H, Sakai K, Nemoto-Hasebe I, Yanagi T, Koizumi H, Shimizu H
    • Journal Title

      J Am Acad Dermatol (in press)

    • Peer Reviewed
  • [Journal Article] Type XVII collagen ELISA indices significantly decreased after bullous pemphigoid remission

    • Author(s)
      Kusajima E, Akiyama M, Sato M, Natsuga K, Shimizu H
    • Journal Title

      Int J Dermatol (in press)

    • Peer Reviewed
  • [Journal Article] Two cases of cutaneous sporotrichosis in continental/microthermal climatezone : global warming alert?

    • Author(s)
      Inokuma D, Shibaki A, Shimizu H
    • Journal Title

      Clin Exp Dermatol (in press)

    • Peer Reviewed
  • [Journal Article] Aleukemic leukemia cutis with extensive bone involvement

    • Author(s)
      Iitani MM, Abe R, Yanagi T, Hamasaka A, Tateishi Y, Abe Y, Ito M, Kondo T, Kubota K, Shimizu H
    • Journal Title

      J Am Acad Dermatol (in press)

    • Peer Reviewed
  • [Journal Article] Transglutaminasel Preferred substrate peptide K5 is an efficient tool in diagnosis of lamellar ichthyosis

    • Author(s)
      Akiyama M, Sakai K, Yanagi T, Fukushima S, Ihn H, Hitomi K, Shimizu H
    • Journal Title

      Am J Pathol (in press)

    • Peer Reviewed
  • [Journal Article] Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis

    • Author(s)
      Abe R, Yamagishi SI, Fujita Y, Hoshina D, Sasaki M, Nakamura K, Matsui T, Shimizu T, Bucala R, Shimizu H
    • Journal Title

      J Dermatol Sci (in press)

    • Peer Reviewed
  • [Presentation] アトピー性皮膚炎におけるフィラグリン遺伝子変異2010

    • Author(s)
      清水宏
    • Organizer
      第34回小児皮膚科学セミナー
    • Place of Presentation
      新宿野村ビル48階野村コンファレンスプラザ東京
    • Year and Date
      2010-03-20
  • [Presentation] Humanization of autoantigen to develop novel models of autoimmunity2010

    • Author(s)
      Shimizu H
    • Organizer
      37th Annual Meeting"Arbeitsgemeinschaft Dermato logische Forschung"
    • Place of Presentation
      Univestity of Lubeck, Lubeck, Germany
    • Year and Date
      2010-02-18
  • [Presentation] アトピー性皮膚炎におけるフィラグリン遺伝子変異2010

    • Author(s)
      清水宏
    • Organizer
      日本皮膚科学会東北六県合同地方会学術大会第349回例会
    • Place of Presentation
      民陵会館2階「記念ホール」仙台
    • Year and Date
      2010-02-07
  • [Presentation] 眼部に生じた壊疽性膿皮症の2例2010

    • Author(s)
      齋藤奈央, 柳輝希, 林欣宇, 笠井聡美, 山根尚子, 猪熊大輔, 加瀬諭, 大野健太郎, 皆川英彦, 清水宏
    • Organizer
      第381回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2010-02-06
  • [Presentation] ステロイド外用にて早期に寛解した小児後天性表皮水疱症の1例2010

    • Author(s)
      林欣宇, 柳輝希, 飯谷麻里夏, 守内玲寧, 崎山幸雄, 清水宏
    • Organizer
      第381回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2010-02-06
  • [Presentation] Yellow nail syndromeの1例2010

    • Author(s)
      林韻欣, 阿部理一郎, 柳輝希, 阿部由紀子, 眞木賀奈子, 清水宏
    • Organizer
      第381回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2010-02-06
  • [Presentation] 重篤な眼症状を伴った木村氏病の1例2010

    • Author(s)
      渡邉美佳, 氏家英之, 齊藤奈央, 柳輝希, 阿部理一郎, 清水宏
    • Organizer
      第381回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2010-02-06
  • [Presentation] ペグインターフェロンfΩ-2bの局所注射にて皮膚潰瘍を生じた1例2010

    • Author(s)
      泉健太郎, 猪熊大輔, 松村若菜, 秦洋郎, 秋山真志, 清水宏, 西谷道子
    • Organizer
      第381回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2010-02-06
  • [Presentation] 角層下膿疱症(Subcorneal pustular dermatosis : SPD)の1例.2010

    • Author(s)
      水野修, 阿部理一郎, 新熊悟, 阿部由紀子, 清水宏
    • Organizer
      第381回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2010-02-06
  • [Presentation] 骨髄異形成症候群を合併した壊疽性膿皮症の1例2010

    • Author(s)
      松村若菜, 氏家英之, 泉健太郎, 秋山真志, 清水宏, 今野哲, 重松明男, 小野澤真弘
    • Organizer
      第381回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2010-02-06
  • [Presentation] アトピー性皮膚炎の予防・治療法の開発及び確立に関する研究2010

    • Author(s)
      清水宏, 戸倉新樹, 秋山真志, 有田賢
    • Organizer
      免疫アレルギ疾患等予防・治療研究事業研究報告会
    • Place of Presentation
      KKRホテル東京10階瑞宝の間東京
    • Year and Date
      2010-01-26
  • [Presentation] Genetic variation of DSG3 is associated with pemphigus vulgaris among Japanese2009

    • Author(s)
      Niizeki H, Asada H, Amagai M, Oka A, Inoko H, Hashimoto T, Ikeda S, Shimizu H, Kitajima Y, Miyagawa S, Yamamoto S, Aoyama Y, Ichiki Y, Shimizu T, Takahashi H, Kuwana M, Shirakata Y, Hashimoto K, Yamamoto T, Iwatsuki K, Inaoki M, Fujimoto W, Nakamura K, Kishimoto K, Kaneko F, Kunii T, Aiba S, Terui T
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      JAL resort, Fukuoka, Japan
    • Year and Date
      20091204-20091206
  • [Presentation] Genotoxic Stress Induces Hair Graying Through Melanocyte Stem Cell Differentiation in the niche2009

    • Author(s)
      Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E, Masunaga T, Shimizu H, Nishimura EK
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      JAL resort, Fukuoka, Japan
    • Year and Date
      20091204-20091206
  • [Presentation] Novel mutation of FLG, p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese atopic dermatitis patients2009

    • Author(s)
      Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean W, Shimizu H
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      JAL resort, Fukuoka, Japan
    • Year and Date
      20091204-20091206
  • [Presentation] Presence of plectin rodless isoform is a key predictor of phenotypic severity in plectin deficient epidermolysis bullosa simpex2009

    • Author(s)
      Natsuga K, Nishie W, Akiyama M, Shinkuma S, Nakamura H, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Leena B-T, Shimizu H
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      JAL resort, Fukuoka, Japan
    • Year and Date
      20091204-20091206
  • [Presentation] Expression of ABCA subfamily member in the epidermis is affected by knockout of ABCA122009

    • Author(s)
      Long HA, Akiyama M, Yanagi T, Shimizu H
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      JAL resort, Fukuoka, Japan
    • Year and Date
      20091204-20091206
  • [Presentation] Establishment of a novel experimental model of human angiosarcoma2009

    • Author(s)
      Hoshina D, Abe R, Hata H, Fujita Y, Yoshioka N, Aoyagi T, Shimizu H
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      JAL resort, Fukuoka, Japan
    • Year and Date
      20091204-20091206
  • [Presentation] Stem cell transplantation treatment restores deficient type XVII collagen in junctional epidermolysis bullosa model mice2009

    • Author(s)
      Fujita Y, Abe R, Inokuma D, Sasaki M, Natsuga K, Nishie W, Nakamura H, Akiyama M, Sawamura D, Shimizu H
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      JAL resort, Fukuoka, Japan
    • Year and Date
      20091204-20091206
  • [Presentation] Development of a rapid immunochromatographic test for the detection of high-level serum ranulysin in an early stage of SJS and TEN2009

    • Author(s)
      Abe R, Yoshioka N, Murata J, Fujita Y, Hoshina D, Mae H, Shimizu H
    • Organizer
      The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      JAL resort, Fukuoka, Japan
    • Year and Date
      20091204-20091206
  • [Presentation] フィラグリン遺伝子変異を有するアミロイド苔癬2009

    • Author(s)
      野村友希子, 秋山真志, 長谷部育恵, 剱持靖子, 乃村俊史, 清水宏
    • Organizer
      第36回皮膚かたち研究学会学術大会
    • Place of Presentation
      宮崎県医師会館宮崎
    • Year and Date
      20091121-20091122
  • [Presentation] ヒト血管肉腫実験モデルを用いた抗ヒトVEGF抗体(bevacizumab)の抗腫瘍効果の検討2009

    • Author(s)
      保科大地, 阿部理一郎, 秦洋郎, 藤田靖幸, 青柳哲, 清水宏
    • Organizer
      第16回分子皮膚科学フォーラム
    • Place of Presentation
      札幌グランドホテル札幌
    • Year and Date
      20091120-20091121
  • [Presentation] (Symposium)Lessons from a Novel Mouse Model for Epidermolysis Bullosa2009

    • Author(s)
      Shimizu H
    • Organizer
      11th World Congress of Pediatric Dermatology
    • Place of Presentation
      Queen Sirikit National Convention Center, Bangkok, Thailand
    • Year and Date
      20091117-20091118
  • [Presentation] (Symposium)Harlequin Ichthyosis and Lamellar Ichthyosis : Molecular Diagnosis and Prenatal Diagnosis2009

    • Author(s)
      Shimizu H
    • Organizer
      11th World Congress of Pediatric Dermatology
    • Place of Presentation
      Queen Sirikit National Convention Center, Bangkok, Thailand
    • Year and Date
      20091117-20091118
  • [Presentation] Kindler症候群の日本人症例2009

    • Author(s)
      夏賀健, 西江渉, 新熊悟, 中村秀樹, 長崎暁理, 清水宏, 立田彩, 小宮根真弓, 松島陽一郎
    • Organizer
      第31回水疱症研究会
    • Place of Presentation
      大和屋本店・愛媛県医師会館松山
    • Year and Date
      20091031-20091101
  • [Presentation] 重篤な後遺症を残した成人麻疹脳炎の1例2009

    • Author(s)
      飯谷麻里, 伊藤圭, 和田剛志, 澤村淳, 清水宏
    • Organizer
      第60回日本皮膚科学会中部支部学術大会
    • Place of Presentation
      国立京都国際会館京都
    • Year and Date
      20091010-20091011
  • [Presentation] Abca12. -|- harlequin ichthyosis model mouse shows alveolar collapse as well as severe fetal skin barrier defects2009

    • Author(s)
      Yanagi T, Akiyama M, Nishihara H, Sakai K, Nishie W, Tanaka S, Shimizu H
    • Organizer
      The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      20090710-20090712
  • [Presentation] Development of an active bullous pemphigoid mouse model2009

    • Author(s)
      Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Nakamura H, Akiyama M, Shimizu H
    • Organizer
      The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      20090710-20090712
  • [Presentation] A case of disseminated intravascular coagulation associated with Stevens-Johnson syndrome2009

    • Author(s)
      Nomura Y, Abe R, Ota H, Baba K, Hata H, Yamane N, Shimizu H
    • Organizer
      The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      20090710-20090712
  • [Presentation] Bone marrow transplantation restores deficient epidermal basement membrane protein and improves the clinical phenotype in epidermolysis bullosa model mice2009

    • Author(s)
      Fujita Y, Abe R, Inokuma D, Sasaki M, Hoshina D, Nishie W, Natsuga K, McMilan J, Nakamura H, Shimizu H
    • Organizer
      The 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      20090710-20090712
  • [Presentation] 血清granulysin値は重症薬疹の発症早期に上昇する2009

    • Author(s)
      吉岡直也, 阿部理一郎, 村田純子, 藤田靖幸, 清水宏
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      長良川国際会議場岐阜
    • Year and Date
      20090604-20090606
  • [Presentation] 基底細胞癌に対するdouble bladed scalpelを用いたmicrographic surgeryの経験2009

    • Author(s)
      青柳哲, 秦洋郎, 泉建太郎, 清水宏
    • Organizer
      第25回日本皮膚悪性種瘍学会学術大会
    • Place of Presentation
      岡山コンベンションセンター岡山
    • Year and Date
      20090522-20090523
  • [Presentation] 表在播種型汗孔角化症に有棘細胞癌およびBowen病を生じた1例2009

    • Author(s)
      山根尚子, 青柳哲, 馬慶場子, 秦洋郎, 清水宏, 菊池敏郎
    • Organizer
      第25回日本皮膚悪性腫瘍学会学術大会
    • Place of Presentation
      岡山コンベンションセンター岡山
    • Year and Date
      20090522-20090523
  • [Presentation] Hemidesmosomal collagen XVII enhances keratinocyte adhesion to collagen IV, and in p38-MAPK-dependent migration and cell signaling2009

    • Author(s)
      McMillan J, Qiao H, Shibaki A, Long H, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H
    • Organizer
      6th Annual Scientific Meeting Australasian Society for Dermatology Research
    • Place of Presentation
      Courtyard by Marriott Surfers Paradise, QLD, Australia
    • Year and Date
      20090520-20090521
  • [Presentation] Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38-MAPK-dependent migration and cell signaling2009

    • Author(s)
      Qiao H, Shibaki A, Long H, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H, McMillan J
    • Organizer
      the 69th Society for Investigative Dermatology Annual Meeting
    • Place of Presentation
      Palais des congres Montreal, Canada
    • Year and Date
      20090506-20090509
  • [Presentation] OSMR遣伝子変異を確認しえた日本人家族性皮膚限局性アミロイドーシスの1例2009

    • Author(s)
      有田賢, 阿部理一郎, 馬場慶子, 秋山真志, 清水宏
    • Organizer
      第108回日本皮膚科学会総会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡福岡
    • Year and Date
      20090424-20090426
  • [Presentation] 道化師様魚鱗癬モデルマウスは、肺胞拡張不全と重篤な皮膚バリア障害を来す2009

    • Author(s)
      柳輝希, 秋山真志, 西原広史, 坂井香織, 西江渉, 田中仲哉, 清水宏
    • Organizer
      第108回日本皮膚科学会総会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡福岡
    • Year and Date
      20090424-20090426
  • [Presentation] 皮膚結節性アミロイドーシスの2例2009

    • Author(s)
      泉健太郎, 猪熊大輔, 笠井麻希, 藤田靖幸, 氏家英之, 山中快子, 伊藤圭, 清水宏
    • Organizer
      第108回日本皮膚科学会総会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡福岡
    • Year and Date
      20090424-20090426
  • [Presentation] 道化師様魚鱗癬の1例2009

    • Author(s)
      高野優佳子, 後藤瑞生, 甲斐宜貴, 片桐一元, 藤原作平, 関口和人, 泉達郎, 山田喜三郎, 中塚和夫, 秋山真志, 清水宏
    • Organizer
      第108回日本皮膚科学会総会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡福岡
    • Year and Date
      20090424-20090426
  • [Presentation] フィラグリン遺伝子変異関連アトピー性皮膚炎では、臨床重症度とバリア障害重証度は相関する2009

    • Author(s)
      長谷部育恵, 秋山真志, 乃村後史, Sandilands A, Mclean I, 清水宏
    • Organizer
      第108回日本皮膚科学会総会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡福岡
    • Year and Date
      20090424-20090425
  • [Presentation] 幽門閉鎖合併単純型表皮水疱症におけるプレクチン発現パターンの解析2009

    • Author(s)
      清水宏, 夏賀健, 西江渉
    • Organizer
      稀少難治性皮膚疾患に関する調査研究班 平成21年度第2回総会
    • Place of Presentation
      KKRホテル東京11階丹頂の間東京
    • Year and Date
      2009-12-18
  • [Presentation] 塊状のIgA沈着を呈したDuhring疱疹状皮膚炎の1例2009

    • Author(s)
      林欣宇, 氏家英之, 渡邉美佳, 馬場慶子, 新熊悟, 阿部理一郎, 清水宏
    • Organizer
      第380回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2009-12-12
  • [Presentation] 第2期梅毒の1例2009

    • Author(s)
      林韻欣, 藤田靖幸, 有田賢, 清水宏
    • Organizer
      第380回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2009-12-12
  • [Presentation] 腹部に生じた血管肉腫の1例2009

    • Author(s)
      本間英里奈, 青柳哲, 笠井聡美, 松村若菜, 渡邉美佳, 馬場慶子, 飯谷麻里, 秦洋郎, 藤田靖幸, 清水宏
    • Organizer
      第380回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2009-12-12
  • [Presentation] 皮下型平滑筋肉腫の1例2009

    • Author(s)
      馬場慶子, 青柳哲, 西村真智子, 秦洋郎, 清水宏, 松村和子
    • Organizer
      第380回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2009-12-12
  • [Presentation] 筋肉内浸潤および脾梗塞を呈した進行期菌状息肉症の1例2009

    • Author(s)
      渡邉美佳, 氏家英之, 馬場慶子, 阿部理一郎, 芝木晃彦, 山田洋介, 山口圭介, 神山俊哉, 清水宏
    • Organizer
      第380回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2009-12-12
  • [Presentation] Wells症候群との鑑別を要したアレルギー性肉芽種性血管炎(AGA)の1例2009

    • Author(s)
      松村若菜, 藤田靖幸, 馬場慶子, 山根尚子, 芝木晃彦, 清水宏, 片岡浩
    • Organizer
      第380回日本皮膚科学会北海道地方会
    • Place of Presentation
      北海道大学学術交流会館札幌
    • Year and Date
      2009-12-12
  • [Presentation] Humanization of autoantigen:水疱性類天疱瘡の病態解明と新規治療法開発2009

    • Author(s)
      清水宏
    • Organizer
      第37回日本臨床免疫学会総会
    • Place of Presentation
      東京ステーションコンファレンス東京
    • Year and Date
      2009-11-14
  • [Presentation] アトピー性皮膚炎患者におけるフィラグリン遺伝子変異2009

    • Author(s)
      清水宏
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      国立京都国際会館京都
    • Year and Date
      2009-11-07
  • [Presentation] 亜鉛による歯科金属アレルギーの1例2009

    • Author(s)
      齋藤奈央, 山根尚子, 松村若菜, 藤田靖幸, 猪熊大輔, 黒嶋伸一郎, 浜坂幸吉, 清水宏
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      国立京都国際会館京都
    • Year and Date
      2009-11-07
  • [Presentation] 血漿交換療法が著効した中毒性表皮壊死症の一例2009

    • Author(s)
      馬場慶子, 阿部理一郎, 飯谷麻里, 猪熊大輔, 三浦正義, 安藤佐土美, 松村和子, 清水宏
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      国立京都国際会館京都
    • Year and Date
      2009-11-07
  • [Presentation] フィラグリン遺伝子変異による皮膚バリア機能障害は、アトピー性皮膚炎の重要な発症因子である2009

    • Author(s)
      清水宏
    • Organizer
      第61回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      別府国際コンベンションセンター大分
    • Year and Date
      2009-10-25
  • [Presentation] 北海道で発症したスポロトリコーシス2009

    • Author(s)
      猪熊大輔, 芝木晃彦, 清水宏, 芝木秀臣
    • Organizer
      第61回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      別府国際コンベンションセンター大分
    • Year and Date
      2009-10-25
  • [Presentation] (Plenary Lecture)"Mouse models of human diseases"2009

    • Author(s)
      Shimizu H
    • Organizer
      The 18th Annual Meeting of the European Academy of Dermatology and Venereology
    • Place of Presentation
      The Internationales Congress Centrum Berlin, Berlin, Germany
    • Year and Date
      2009-10-08
  • [Presentation] (JSID Symposium)Atopic dermatitis : Its skin barrier function and filaggrin mutations2009

    • Author(s)
      Shimizu H
    • Organizer
      The 18th Congress of the European Academy of Dermatology and Venereology
    • Place of Presentation
      The Internationales Congress Centrum Berlin, Berlin, Germany
    • Year and Date
      2009-10-07
  • [Presentation] 11歳男児にみられた乳腺嚢胞の1例2009

    • Author(s)
      林韻欣, 青柳哲, 齋藤奈央, 秦洋郎, 芝木晃彦, 清水宏
    • Organizer
      第379回日本皮膚科学会北海道地方会
    • Place of Presentation
      大正富山医薬品(株)5階会議室札幌
    • Year and Date
      2009-10-03
  • [Presentation] 胸肋関節から生じた皮膚腺病の一例2009

    • Author(s)
      松村若菜, 阿部理一郎, 泉健太郎, 保科大地, 阿部由紀子, 清水宏
    • Organizer
      第379回日本皮膚科学会北海道地方会
    • Place of Presentation
      大正富山医薬品(株)5階会議室札幌
    • Year and Date
      2009-10-03
  • [Presentation] プレクチンの発現様式の違いによって2種類の表皮水疱症の臨床型が決定される2009

    • Author(s)
      夏賀健, 西江渉, 秋山真志, 新熊悟, 中村秀樹, 長崎暁理, Has C, 大内健嗣, 石河晃, 平子義章, 尾張部克志, 澤村大輔, Leena B-T, 清水宏
    • Organizer
      第379回日本皮膚科学会北海道地方会
    • Place of Presentation
      大正富山医薬品(株)5階会議室札幌
    • Year and Date
      2009-10-03
  • [Presentation] 表皮水疱症の新しい治療法"骨髄移植"2009

    • Author(s)
      清水宏
    • Organizer
      第73回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      甲府富士屋ホテル山梨
    • Year and Date
      2009-09-27
  • [Presentation] 汎発性膿疱性乾癬に進展したPsoriatic onycho-pachydermo periostitis(POPP)の1例2009

    • Author(s)
      渡遷美佳, 氏家英之, 飯谷麻里, 阿部理一郎, 清水宏
    • Organizer
      第73回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      甲府富土屋ホテル山梨
    • Year and Date
      2009-09-27
  • [Presentation] タクロリム軟膏外用が奏効した爪扁平苔癬5例のまとめ2009

    • Author(s)
      氏家英之, 芝木晃彦, 秋山真志, 清水宏
    • Organizer
      第73回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      甲府富土屋ホテル山梨
    • Year and Date
      2009-09-27
  • [Presentation] 周囲への浸潤傾向を示した顆粒細胞腫の1例2009

    • Author(s)
      洪綺憶, 青柳哲, 本間英里奈, 西村真智子, 笠井麻希, 秦洋郎, 松村和子, 清水宏
    • Organizer
      第73回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      甲府富土屋ホテル山梨
    • Year and Date
      2009-09-27
  • [Presentation] Gemcitabineにより強皮症様皮疹を呈した一例2009

    • Author(s)
      笠井聡美, 阿部理一郎, 泉健太郎, 藤田靖幸, 阿部由紀子, 清水宏, 桑名将城, 河上洋
    • Organizer
      第73回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      甲府富土屋ホテル山梨
    • Year and Date
      2009-09-27
  • [Presentation] Plectin expression in epidermolysis bullosa simplex(EBS)with muscular dystrophy vs.in EBS with pyloric atresia2009

    • Author(s)
      Natsuga K, Nishie W, Akiyama M, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Buckner-Tuderman L, Shimizu H
    • Organizer
      The 39th European Society for Dermatological Research(ESDR)Annual Meeting
    • Place of Presentation
      Semmelweis University, Budapest, Hungary
    • Year and Date
      2009-09-10
  • [Presentation] ABCA subfamily member expression in the epidermis is altered by knockdown of ABCA122009

    • Author(s)
      Long H, Akiyama M, Yanagi T, Shimizu H
    • Organizer
      The 39th European Society for Dermatological Research(ESDR)Annual Meeting
    • Place of Presentation
      Semmelweis University, Budapest, Hungary
    • Year and Date
      2009-09-10
  • [Presentation] Both hematopoietic and mesenchymal stem cells contribute to the production of basement membrane protein in bone marrow transplantation treatment model mouse2009

    • Author(s)
      Fujita Y, Abe R, Inokuma D, Nishie W, Nakamura H, Akiyama M, Sawamura D, Shimizu H
    • Organizer
      The 39th European Society for Dermatological Research(ESDR)Annual Meeting
    • Place of Presentation
      Semmelweis University, Budapest, Hungary
    • Year and Date
      2009-09-10
  • [Presentation] Collagen XVII in hemidesmosomes is involved in keratinocyte-collagen IV adhesion and p38-MAPK-dependent cell migration and signaling2009

    • Author(s)
      McMillan J, Qiao H, Shibaki A, Long H, Wang G, Nishie W, Akiyama M, Shimizu H
    • Organizer
      The 39th European Society for Dermatological Research(ESDR)Annual Meeting
    • Place of Presentation
      Semmelweis University, Budapest, Hungary
    • Year and Date
      2009-09-10
  • [Presentation] Transdifferentiation of bone marrow stem cells into keratinocytes2009

    • Author(s)
      Shimizu H
    • Organizer
      EB 2009
    • Place of Presentation
      Mariott Hotel, Vienna, Austria
    • Year and Date
      2009-09-07
  • [Presentation] Novel animal models for skin diseases : Message from Sapporo2009

    • Author(s)
      Shimizu H
    • Organizer
      ADA 129th Annual Meeting
    • Place of Presentation
      Park City, Htah, U.S.A
    • Year and Date
      2009-08-22
  • [Presentation] 発熱を伴った紅斑、丘疹2009

    • Author(s)
      飯谷麻里, 小玉和郎, 馬場慶子, 野村友希子, 川崎浩之, 山中快子, 阿部由紀子, 阿部理一郎, 清水宏
    • Organizer
      第25回皮膚病理組織学会
    • Place of Presentation
      石垣記念ホール東京
    • Year and Date
      2009-07-29
  • [Presentation] 筋ジストロフィー合併単純型表皮水疱症におけるプレクチン発現パターンの解析2009

    • Author(s)
      清水宏, 夏賀健, 西江渉
    • Organizer
      稀少難治性皮膚疾患に関する調査研究班 平成21年度第1回総会
    • Place of Presentation
      KKRホテル東京11階丹頂の間東京
    • Year and Date
      2009-07-24
  • [Presentation] 頭皮円形欠損部に対する簡便な局所皮弁による再建例2009

    • Author(s)
      青柳哲, 本間英里奈, 秦洋郎, 清水宏
    • Organizer
      第24回日本皮膚外科学会・学術大会
    • Place of Presentation
      名鉄犬山ホテル愛知
    • Year and Date
      2009-06-21
  • [Presentation] 播種性血管内凝固症候群を合併したStevens-Johnson syndromeの1例2009

    • Author(s)
      野村友希子, 阿部理一郎, 太田光, 馬場慶子, 秦洋郎, 山根尚子, 清水宏
    • Organizer
      第378回日本皮膚科学会北海道地方会
    • Place of Presentation
      旭川市大雪クリスタルホール旭川
    • Year and Date
      2009-06-14
  • [Presentation] 北海道で発症したスポロトリコーシス2009

    • Author(s)
      猪熊大輔, 芝木晃彦, 清水宏, 芝木秀臣
    • Organizer
      第378回日本皮膚科学会北海道地方会
    • Place of Presentation
      旭川市大雪クリスタルホール旭川
    • Year and Date
      2009-06-14
  • [Presentation] 水疱性類天疱瘡:up-date2009

    • Author(s)
      清水宏
    • Organizer
      第1回関西皮膚自己免疫疾患談話会
    • Place of Presentation
      大阪リーガロイヤルホテルタワーウイング2階「桐の間」大阪
    • Year and Date
      2009-06-12
  • [Presentation] 水疱性類天疱瘡の病態解明と新規治療法の開発2009

    • Author(s)
      清水宏
    • Organizer
      第46回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム東京
    • Year and Date
      2009-04-13
  • [Book] Treatment of Skin Disease 3rd Edition-Comprehensive Therapeutic Strategies2010

    • Author(s)
      Tsuji-Abe, Y., Shimizu, H.
    • Total Pages
      2
    • Publisher
      Mosby-Elsevier
  • [Book] 皮膚科診療カラーアトラス大系2009

    • Author(s)
      乃村俊史, 清水宏
    • Total Pages
      4
    • Publisher
      講談社
  • [Book] 臨床検査データブック2009-20102009

    • Author(s)
      清水宏
    • Total Pages
      2
    • Publisher
      医学書院
  • [Book] 皮膚疾患最新の治療2009-20102009

    • Author(s)
      清水宏
    • Total Pages
      1
    • Publisher
      南江堂
  • [Book] からだの科学2009

    • Author(s)
      新熊悟, 夏賀健, 清水宏
    • Total Pages
      5
    • Publisher
      日本評論社
  • [Book] 第2版 皮膚疾患診療 実践ガイド 皮膚科遺伝相談2009

    • Author(s)
      守内玲寧, 芝木晃彦, 清水宏
    • Total Pages
      2
    • Publisher
      文光堂
  • [Book] 第2版 皮膚疾患診療 実践ガイド 膿疱を生じる疾患2009

    • Author(s)
      守内玲寧, 芝木晃彦, 清水宏
    • Total Pages
      1
    • Publisher
      文光堂
  • [Book] 第2版 皮膚疾患診療 実践ガイド 水疱を生じる疾患2009

    • Author(s)
      守内玲寧, 芝木晃彦, 清水宏
    • Total Pages
      1
    • Publisher
      文光堂

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Published: 2011-06-16   Modified: 2016-04-21  

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