2011 Fiscal Year Final Research Report
Elucidating gene X environment interaction in the pathophysiology of schizophrenia using twin research
| Project/Area Number |
21249064
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KASAI Kiyoto 東京大学, 医学部附属病院, 教授 (80322056)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Tadafumi 独立行政法人理化学研究所, チームリーダー (30214381)
ABE Osamu 東京大学, 医学部附属病院, 講師 (50302716)
KAKIUCHI Chihiro 独立行政法人理化学研究所, 客員研究員 (90342766)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 精神生理学 |
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| Research Abstract |
We collected neuroimaging and blood samples from monozygotic and dizygotic twin pairs and from patients with schizophrenia. We recruited 62 healthy twin adults and 44 twin children. MEG recording of mismatch negativity(MMN) indicated that MMN is heritable. MMN was associated with genetic variation in the GRM3. These results suggest that MMN may be a useful intermediate phenotype for schizophrenia. We also showed that prefrontal cortex activation as measured by NIRS may be also heritable and that these indices were significantly reduced in early phases of schizophrenia, which indicates the usefulness of NIRS as an efficient intermediate phenotype for schizophrenia.
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[Journal Article] Reply to "Neurogenetic effects of OXTR rs2254298 in the extended limbic system of healthy Caucasian adults"2011
Author(s)
Yamasue H, Suga M, Yahata N, Inoue H, Tochigi M, Abe O, Xiaoxi Liu, Kawamura Y, Mark A Rogers, Takei K, Yamada H, Aoki S, Sasaki T, Kasai K
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Journal Title
Biol Psychiatry
Volume: 70
Pages: e41-42
Peer Reviewed
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[Journal Article] Different hemodynamic response patterns in the prefrontal cortical sub-regions according to the clinical stages of psychosis2011
Author(s)
Koike S, Takizawa R, Nishimura Y, Takano Y, Takayanagi Y, Kinou M, Araki T, Harima H, Fukuda M, Okazaki Y, Kasai K
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Journal Title
Schizophr Res
Volume: 132
Pages: 54-61
Peer Reviewed
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[Journal Article] Association between the oxytocin receptor gene(OXTR) and amygdalar volume in healthy adults2010
Author(s)
Inoue H, Yamasue H, Tochigi M, Abe O, Liu X, Kawamura Y, Takei K, Suga M, Yamada H, Rogers MA, Aoki S, Sasaki T, Kasai K
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Journal Title
Biol Psychiatry
Volume: 68
Pages: 1066-1072
Peer Reviewed
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[Journal Article] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes2010
Author(s)
Inoue H, Yamasue H, Tochigi M, Takei K, Suga M, Abe O, Yamada H, Rogers MA, Aoki S, Sasaki T, Kasai K
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Journal Title
Brain Re
Volume: 331
Pages: 51-57
Peer Reviewed
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[Journal Article] Functional(GT) n polymorphisms in promoter region of N-methyl-D-aspartate receptor 2A subunit(GRIN2A) gene affect hippocampal and amygdala volumes2010
Author(s)
Inoue H, Yamasue H, Tochigi M, Suga M, Iwayama Y, Abe O, Yamada H, Rogers M, Aoki S, Kato T, Sasaki T, Yoshikawa T, Kasai K
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Journal Title
Genes Brain Behav
Volume: 9
Pages: 269-275
Peer Reviewed
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[Journal Article] Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia2010
Author(s)
Takayanagi Y, Takahashi T, Orikabe L, Masuda N, Mozue Y, Nakamura K, Kawasaki Y, Itokawa M, Sato Y, Yamasue H, Kasai K, Okazaki Y, Suzuki M
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Journal Title
Schizophr Res
Volume: 121
Pages: 55-65
Peer Reviewed
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