動体追跡医科学研究

2011 Fiscal Year Annual Research Report

• Project/Area Number: 21249065
• Research Institution: Hokkaido University
• Principal Investigator: 白土 博樹 北海道大学, 大学院・医学研究科, 教授 (20187537)
• Co-Investigator(Kenkyū-buntansha): 本間 さと 北海道大学, 大学院・医学研究科, 教授 (20142713) ; 玉木 長良 北海道大学, 大学院・医学研究科, 教授 (30171888) ; 芳賀 永 北海道大学, 大学院・先端生命科学研究院, 准教授 (00292045) ; 但野 茂 北海道大学, 大学院・工学研究科, 教授 (50175444) ; 石川 正純 北海道大学, 大学院・医学研究科, 教授 (80314772)
• Keywords: 量子線シミュレーション / 電子線トラック解析 / モンテカルロ法 / 放射線治療 / プラスチック檢出器 / 体幹部定位放射線照射 / 非線形最適化

Research Abstract

放射線を軸に、ナノレベルの物理現象から社会的存在としての患者まで生体の動体追跡科学の基盤研究を行った。
3次元培養環境下において、癌細胞の運動や増殖、放射線等への耐性を経時的かつ定量的に解析できる実験系を確立し、細胞外基質の存在によるバックグラウンド(自家蛍光)が観察の支障となるが、近赤外波長域を用いることによりS/N比を改善することができた。
10Gyの放射線照射に生残したヒト肺腺癌由来細胞A549細胞における転写因子ATF5の発現と浸潤能の亢進との関係について調べた.その結果,コラーゲンゲルを用いた3次元培養環境下では,放射線照射に生残した細胞株のATF5発現が有意に上昇し,浸潤能の亢進をもたらすことをRNA干渉法によって明らかにした。放射線耐性細胞においてHIF-1α (hypoxic-inducible factor 1alpha)が浸潤・転移といった悪性度に関与している可能性が高いことがmRNA発言の解析から示された。
24~72時間の間マウスに発光基質であるルシフェリンを連続投与しながら、体全体の発光を安定してイメージングする実験系を確立した。自由行動マウスの目的部位を追跡しながら、その部位の発光量の3次元空間内での補正するプログラムのプロトタイプが完成した。
動体追跡技術による体動の検出結果に基づく四次元PET撮影やCT撮影および再構成のための基礎検討として,位相分割時の投影データの角度分散のシミュレーションおよび限られた投影データからの再構成画像の画質評価を行い,本手法による四次元CT再構成の実現性および課題について検証した。
Linear-quadratic modelを利用した線量分割方法の最適化に関する検討を実施し、数理的フレームを構築し、動体追跡照射で、分割照射が適切な場合とそうではない場合を明確にした。
胃腸の動体追跡科学の基本となる生体への金マーカーの刺入技術の改良を行った。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

1)基礎的動体追跡技術のための顕微鏡開発につながり、2)in vitroの細胞動体追跡科学の研究が3次元培養という新しい方法との融合に発展し、3)小動物の観察ボックス内での動体追跡科学の知見が広がり、4)ヒト臓器内の動体追跡科学の研究は、カプセル内視鏡の活用よりも内視鏡下の金マーカー刺入術が改良され、胃リンパ腫に対する金マーカーを活用した、動体追跡放射線治療の有用性が臨床的に示された。

Strategy for Future Research Activity

放射線治療の臨床研究に端を発した動体追跡医科学は、PETに利用から細胞内の生体反応の解明まで、予想を超える規模に発展し、現在、動体追跡用顕微鏡や、3次元培養細胞系を利用したあらたな学問体系の発展につながりつつある。今後は、同技術を活用して、どのような「新しい知」が生まれるか、をさらに研究する必要がある。時間的連続体としての生体の解明と疾病の克服のために、研究者の幅を広げていく必要がある。その対応策として、他外部資金等を獲得しながら、世界的な研究者を集め、総合的な研究ができる拠点形成へ発展させることを検討する。

Research Products

• [Journal Article] Usefulness of portography and contrast-enhanced computed tomography to predict the embolized area in percutaneous transhepatic portal vein embolization with absolute ethanol under temporary balloon occlusion (2012)
  • Author(s): Hasegawa Y, Abo D, Sakuhara Y, Kato F, Kamishimma T, Shimizu T, Ito YM, Terae S, Shirato H
  • Journal Title: Jpn J Radiol Volume: 30(1) Pages: 53-61
  • DOI: doi: 10.1007/s11604-011-0008-9
  • Peer Reviewed
• [Journal Article] A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear-Quadratic Model (2012)
  • Author(s): Mizuta M, Takao S, Date H, Kishimoto N, Sutherland KL, Onimaru R, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84(3) Pages: 829-833
  • DOI: doi: 10.1016/j.ijrobp.2012.01.004
  • Peer Reviewed
• [Journal Article] A New Brain Positron Emission Tomography Scanner with Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients with Nasopharyngeal Carcinoma (2012)
  • Author(s): Katoh N, Yasuda K, Shiga T, Hasegawa M, Onimaru R, Shimizu S, Bengua G, Ishikawa M, Tamaki N, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 15;82(4) Pages: 671-676
  • DOI: 10.1016/j.ijrobp.2011.09.011
  • Peer Reviewed
• [Journal Article] De novo synthesis of PERIOD initiates circadian oscillation in cultures mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide (2012)
  • Author(s): Nishide S, Ono D, Yamada Y, Honma S, Honma K
  • Journal Title: Eur J Neurosci Volume: 35 Pages: 291-299
  • DOI: 10.1111/j.1460-9568.2011.07952.x
  • Peer Reviewed
• [Journal Article] Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis (2012)
  • Author(s): Kwon HJ, Ohmiya Y, Honma K-I, Hnma S, nagai T, Saito K, Yasuda K
  • Journal Title: Cell Death and Disease Volume: 3 Pages: e278
  • DOI: 10.1038/cddis.2012.20
  • Peer Reviewed
• [Journal Article] JNK regulates the photic response of the mammalian circadian clock (2012)
  • Author(s): Yoshitane H, Honma S, Imamura K, Nakajima H, Nishide S, Ono D, Kiyota H, Shinozaki N, Matsuki H, Wada N, Doi H, Hamada T, Honma K, Fukada Y
  • Journal Title: EMBO Report Volume: (In press)
  • Peer Reviewed
• [Journal Article] 18F-Fluoromisonidazole positron emission tomography may differentiate glioblastoma multiforme from less malignant gliomas (2012)
  • Author(s): Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, Yamaguchi S, Houkin K, Tanaka S, Kuge Y, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: (In press)
  • DOI: 10.1007/s00259-011-2037-0
  • Peer Reviewed
• [Journal Article] Lysyl Oxidase : From Basic Science to Future Cancer Treatment (2012)
  • Author(s): Nishioka T., Eustace A., West C.M.
  • Journal Title: Cell Structure and Function Volume: (in press)
  • Peer Reviewed
• [Journal Article] 肺癌治療における新しい放射線療法 (2012)
  • Author(s): 早川和重
  • Journal Title: 成人病と生活習慣病 Volume: 42(1) Pages: 81-86
• [Journal Article] Use of implanted markers and interportal adjustment with real-time tracking radiotherapy system to reduce intrafraction prostate motion (2011)
  • Author(s): Shimizu S, Osaka Y, Shinohara N, Sazawa A, Nishioka K, Suzuki R, Onimaru R, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 81(4) Pages: 393-399
  • DOI: doi10.1016/j.ijrobp.2011.04.043
  • Peer Reviewed
• [Journal Article] Relationship Between Diseased Lung Tissues on Computed Tomography and Motion of Fiducial Marker Near Lung Cancer (2011)
  • Author(s): Onodera Y, Nishioka N, Yasuda K, Fujima N, Torres M, Kamishima T, Ooyama N, Onimaru R, Terae S, Oizumi S, Nishimura M, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 79 (5) Pages: 1408-1413
  • DOI: doi:10.1016/j.ijrobp.2010.01.008
  • Peer Reviewed
• [Journal Article] Long-term outcomes of fractionated stereotactic radiotherapy for intracranial skull base benign meningiomas in single institution (2011)
  • Author(s): Onodera S, Aoyama H, Katoh N, Taguchi H, Yasuda K, Yoshida D, Surtherland K, Suzuki R, Ishikawa M, Gerard B, Terasaka S, Shirato H
  • Journal Title: Jpn J Clin Oncol Volume: 41(4) Pages: 462-468
  • DOI: 10.1093/jjco/hyq231
  • Peer Reviewed
• [Journal Article] Mapping of Cerebral Oxygen Extraction Fraction Changes with Susceptibility-weighted Phase Imaging (2011)
  • Author(s): Zaitsu Y, Kudo K, Terae S, Yazu R, Ishizaka K, Fujima N, Tha KK, Haacke EM, Sasaki M, Shirato H
  • Journal Title: Radiology Volume: 261(3) Pages: 930-936
  • DOI: 10.1148/radiol.11102416
  • Peer Reviewed
• [Journal Article] Power Doppler signal calibration using capillary phantom for pannus vascularity in rheumatoid finger joint (2011)
  • Author(s): Kamishima T, Nishida M, Horie T, Narita A, Sagawa A, Henmi M, Shirato H, Terae S
  • Journal Title: A pilot study. Clin Exp Rheumatol Volume: 29(6) Pages: 1057
  • Peer Reviewed
• [Journal Article] Improved detection of heat stroke-induced brain injury by high b-value diffusion-weighted imaging (2011)
  • Author(s): Kobayashi K, Tha KK, Terae S, Iijima Y, Katabami K, Minami Y, Uegaki S, Gando S, Shirato H
  • Journal Title: J Comput Assist Tomogr Volume: 35(4) Pages: 498-500
  • DOI: 10.1097/RCT.0b013e318222082
  • Peer Reviewed
• [Journal Article] Dynamic MR findings of ductal carcinoma in situ within a fibroadenoma (2011)
  • Author(s): Kato F, Omatsu T, Matsumura W, Takahashi M, Hosoda M, Takahashi H, Kubota K, Oyama-Manabe N, Terae S, Shirato H
  • Journal Title: Magn Reson Med Sci. Volume: 10(2) Pages: 129-132
  • Peer Reviewed
• [Journal Article] Monitoring anti-interleukin 6 receptor antibody treatment for rheumatoid arthritis by quantitative magnetic resonance imaging of the hand and power Doppler ultrasonography of the finger (2011)
  • Author(s): Kamishima T, Tanimura K, Shimizu M, Matsuhashi M, Fukae J, Kon Y, Hagiwara H, Narita A, Aoki Y, Kosaka N, Atsumi T, Shirato H, Terae S
  • Journal Title: Skeletal Radiol Volume: 40(6) Pages: 745-755
  • DOI: 10.1007/s0025-010-1064-4
  • Peer Reviewed
• [Journal Article] Comparison of 1H MR spectroscopy, 3-point DIXON, and multi-echo gradient echo for measuring hepatic fat fraction (2011)
  • Author(s): Ishizaka K, Oyama N, Mito S, Sugimori H, Nakanishi M, Okuaki T, Shirato H, Terae S
  • Journal Title: Magn Reson Med Sci Volume: 10(1) Pages: 41-48
  • Peer Reviewed
• [Journal Article] Feasibility of a dual microcatheter-dual interlocking detachable coil technique in preoperative embolization in preparation for distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer (2011)
  • Author(s): Abo D, Hasegawa Y, Sakuhara Y, Terae S, Shimizu T, Tha KK, Tanaka E, Hirano S, Kondo S, Shirato H
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: (In press)
  • DOI: 10.1016/j.ijrobp.2011.04.043
  • Peer Reviewed
• [Journal Article] Identification and further differentiation of subendocardial and transmural myocardial infarction by fast strain-encoded (SENC) magnetic resonance imaging at 3.0 Tesla (2011)
  • Author(s): Oyama-Manabe N, Ishimori N, Sugimori H, Van Cauteren M, Kudo K, Manabe O, Okuaki T, Kamishima T, Ito YM, Tsutsui H, Tha KK, Terae S, Shirato H
  • Journal Title: Eur Radiol Volume: 21(11) Pages: 2362-2368
  • DOI: 10.1007/s00330-011-2177-4
  • Peer Reviewed
• [Journal Article] Rapid estimation of split renal function in kidney donors using software developed for computed tomographic renal volumetry (2011)
  • Author(s): Kato F, Kamishima T, Morita K, Muto NS, Okamoto S, Omatsu T, Oyama N, Terse S, Kanegae K, Nonomura K, Shirato H
  • Journal Title: Eur J Radiol Volume: 79(1) Pages: 15-20
  • DOI: 10.1016/j.ejrad.2009.11.013
  • Peer Reviewed
• [Journal Article] Renal cortical volume measured using automatic contouring software for computed tomography and its relationship with BMI, age and renal function (2011)
  • Author(s): Muto NS, Kamishima T, Harris AA, Kato F, Onodera Y, Terae S, Shirato H
  • Journal Title: Eur J Radiol Volume: 78(1) Pages: 151-156
  • DOI: 10.1016/j.ejrad.2009.10.005
  • Peer Reviewed
• [Journal Article] A Pitfall of C-11 Methionine PET : Cerebral Venous Infarction Mimicked a Glioma (2011)
  • Author(s): Harada Y, Hirata K, Kobayashi H, Usui R, Shiga T, Terae S, Shirato H, Tamaki N
  • Journal Title: Clin Nucl Med. Volume: 37(1) Pages: 110-111
  • DOI: 10.1097/RLU.0b013e3182336433
  • Peer Reviewed
• [Journal Article] Accurate analysis of the change in volume, location, and shape of metastatic cervical lymph nodes during radiotherapy (2011)
  • Author(s): Takao S, Tadano S, Taguchi H, Yasuda K, Onimaru R, Ishikawa M, Bengua G, Suzuki R, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 81(3) Pages: 871-879
  • DOI: 10.1016/j.ijrobp.2010.11.078
  • Peer Reviewed
• [Journal Article] Efficacy of therapy for advanced hepatocellular carcinoma : intra-arterial 5-fluorouracil and subcutaneous interferon with image-guided radiation (2011)
  • Author(s): Chuma M, Taguchi H, Yamamoto Y, Shimizu S, Nakanishi M, Ogawa K, Sho T, Horimoto H, Kobayashi T, Nakai M, Terashita K, Sakuhara Y, Abo D, Tsukuda Y, Tsunematsu S, Hige S, Kato M, Shirato H, Asaka M
  • Journal Title: J Gastroenterol Hepatol Volume: 26(7) Pages: 1123-1132
  • DOI: 10.1111/j.1440-1746.2011.06745.x
  • Peer Reviewed
• [Journal Article] Coordinated regulation of differentiation and proliferation of embryonic caraiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway (2011)
  • Author(s): Nakajima K, Inagawa,M, Uchida C, Okada K, Tane S, Kojima M, Kubota M, Noda M, Ogawa S, Shirato H, Sato M, Suzuki-Migishima R, Hino T, Satoh Y Kitaeawa M. Takeuchi T
  • Journal Title: Development Volume: 138(9) Pages: 1771-1782
  • DOI: 10.1016/j.lungcan.2011.02.009
  • Peer Reviewed
• [Journal Article] Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with naclitaxel and carboplatin in locally advanced non-small cell lung cancer (2011)
  • Author(s): Sakakibara-Konishi J, Oizumi S, Kinoshita I, Shinagawa N, Kikuchi J, Kato M, Inoue T, Katoh N, Onimaru R, Shirato H, Dosaka-Akita H, Nishimura M
  • Journal Title: Lung Cancer Volume: 74(2) Pages: 248-252
  • DOI: 10.1016/j.lungca
  • Peer Reviewed
• [Journal Article] Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome (2011)
  • Author(s): Yokota T, Kinugawa S, Okita K, Hirabayashi K, Suga T, Hattori M, Nakagawa Y, Oyama-Manabe N, Shirato H, Tsutsui H
  • Journal Title: Hypertens Res Volume: 34(9) Pages: 1029-1034
  • DOI: 10.1038/hr.2011.78
  • Peer Reviewed
• [Journal Article] Light responsiveness of clock genes, Per1 and Per2, in the olfactory bulb of mice (2011)
  • Author(s): Hamada T, Homna S, Honma K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 409 Pages: 727-731
  • DOI: 10.1016/j.bbrc.2011.05.076
  • Peer Reviewed
• [Journal Article] Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by RORα and their roles in adipogenesis (2011)
  • Author(s): Ozaki N, Noshiro M, Kawamoto T, Nakashima A, Honda K, Fukuzaki-Dohi U, Honma S, Fujimoto K, Tanimoto K, Tanne K, Kato, Y
  • Journal Title: Genes Cells Volume: (In press)
  • Peer Reviewed
• [Journal Article] Dynamic 11 C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas : an experimental study using small animal PET (2011)
  • Author(s): Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa M, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 38 Pages: 1876-1886
  • DOI: 10.1007/s00259-011-1865-2
  • Peer Reviewed
• [Journal Article] Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imagine (2011)
  • Author(s): Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 38 Pages: 742-752
  • DOI: 10.1007/s00259-010-1683-y
  • Peer Reviewed
• [Journal Article] Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions (2011)
  • Author(s): Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima K, Kuge Y, Tamaki N
  • Journal Title: Ann Nuci Med Volume: 25 Pages: 213-220
  • DOI: 10.1007/s12149-010-0450-2
  • Peer Reviewed
• [Journal Article] 区間殖関数データの微分とその応用 (2011)
  • Author(s): 池田智健・小官由里子・南弘征・水田正弘
  • Journal Title: 計算機統計学 Volume: 23 Pages: 113-123
  • Peer Reviewed
• [Journal Article] Electron Track Analysis for Damage Formation in Bio-Cells (2011)
  • Author(s): Y.Yoshii, K.L.Sutherland, H.Date
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 269 Pages: 1887-1891
  • DOI: 10.1016/j.nimb.2011.05.028
  • Peer Reviewed
• [Journal Article] Electron Transport Properties in TRIES (HSi(OC_2H_5)_3) Vapor (2011)
  • Author(s): Kosaku Yoshida, Ran Sato, Takuya Yokota, Yasutaka Kishimoto, Hiroyuki Date
  • Journal Title: Japanese Journal of Applied Physics Volume: 50 Pages: 120210(1-3)
  • DOI: 10.1143/JJAP.50.120210
  • Peer Reviewed
• [Journal Article] Contribution of the central thalamus to the generation of volitional saccades (2011)
  • Author(s): Tanaka, M., Kunimatsu, J.
  • Journal Title: Eur.J.Neurosci. Volume: 33 Pages: 2046-2057
  • DOI: 10.1111/j.1460-9568.2011.07699.x
  • Peer Reviewed
• [Journal Article] 眼球運動制御からみた視床大脳経路の機能解析 (2011)
  • Author(s): 國松淳、田中真樹
  • Journal Title: 脳と神経Brain and Nerve Volume: 63 Pages: 871-877
• [Journal Article] Active fluctuation in the cortical cytoskeleton observed by high-speed live-cell scanning probe microscopy (2011)
  • Author(s): K.Tamura, T.Mizutani, H.Haga, K.Kawabata
  • Journal Title: Acta Biomater. Volume: 7 Pages: 3766-3772
  • DOI: 10.1016/j.actbio.2011.06.013
  • Peer Reviewed
• [Journal Article] Evaluation of small bowel blood flow in healthy subjects receiving low-dose aspirin (2011)
  • Author(s): Nishida U, Kato M, Nishida M, Kamada G, Yoshida T, Ono S, Shimizu Y, Asaka M
  • Journal Title: World J Gastroenterol Volume: 17 Pages: 226-230
  • DOI: 10.3748/wjg.v17.i2.226
  • Peer Reviewed
• [Journal Article] Evaluation of gastrointestinal injury and blood flow of small bowel during low dose aspirin administration (2011)
  • Author(s): Nishida U, Kato M, Nishida M, Kamada G, Ono S, Shimizu Y, Fujimori R, Asaka M
  • Journal Title: J Clin Biochem Nutr Volume: 48 Pages: 245-250
  • DOI: 10.3164/jcbn.10-112
  • Peer Reviewed
• [Journal Article] Triple Therapy with Ecabet Sodium, Amoxicillin and Lansoprazole for 2 Weeks as the Rescue Regimen for H.pylori Infection (2011)
  • Author(s): Furuta T, Kato M, Sugimoto M, Sasaki M, Kamoshida T, Furukawa K, Inaba T, Tomita T, Shirai T, Ishii N, Nomura H, Konda Y, Asaka M
  • Journal Title: Intern Med Volume: 50 Pages: 369-374
  • DOI: 10.2169/internalmedicine.50.4305
  • Peer Reviewed
• [Journal Article] Target biopsy using magnifying endoscopy in clinical management of gastric MALT lymphoma (2011)
  • Author(s): Ono S, Kato M, Ono Y, Nishida U, Yamamoto K, Shimizu Y, Asaka M
  • Journal Title: J Gastroenterol Hepatol. Volume: 26 Pages: 1133-1138
  • DOI: 10.1111/j.1440-1746.2011.06729.x
  • Peer Reviewed
• [Journal Article] Clinicopathological analysis of early-stage gastric cancers detected after successful eradication of Helicobacter pylori (2011)
  • Author(s): Yamamoto K, Kato M, Takahashi M, Haneda M, Shinada K, Nishida U, Yoshida T, Sonoda N, Ono S, Nakagawa M, Mori Y, Nakagawa S, Mabe K, Shimizu Y, Moriya J, Kubota K, Matsuno Y, Shimoda T, Watanabe H, Asaka M
  • Journal Title: Helicobacter Volume: 16 Pages: 21021-21026
  • DOI: 10.1111/j.1523-5378.2011.00833.x.
  • Peer Reviewed
• [Journal Article] DNA vaccination targeting macrophage migration inhibitory factor prevents murine experimental colitis (2011)
  • Author(s): Ohkawara T, Koyama Y, Onodera S, Takeda H, Kato M, Asaka M, Nishihira J
  • Journal Title: Clin Exp Immunol. Volume: 163 Pages: 113-122
  • DOI: 10.1111/j.1365-2249.2010.04277.x.
  • Peer Reviewed
• [Journal Article] Macrophage migration inhibitory factor contributes to development of nonsteroidl anti-inflanunatory drugs-induced gastric injury in mice (2011)
  • Author(s): Ohkawara T, Takeda H, Ohnishi S, Kato M, Nishihira J, Asaka M
  • Journal Title: Int Immunopharmacol Volume: 11 Pages: 418-423
  • DOI: 10.1016/j.intimp.2010.12.009
  • Peer Reviewed
• [Journal Article] Carbon dioxide insufflation during endoscopic retrograde cholangiopancreatography reduces bowel gas volume but does not affect visual analogue scale scores of suffering : a prospective, double-blind, randomized, controlled trial.. (2011)
  • Author(s): Kuwatani M, Kawakami H, Hayashi T, Ishiwatari H, Kudo T, Yamato H, Ehira N, Haba S, Eto K, Kato M, Asaka M
  • Journal Title: Surg Endosc Volume: 25 Pages: 3784-3790
  • DOI: 10.1007/s00464-011-1789-8
  • Peer Reviewed
• [Journal Article] Radiotherapy quality assurance review for a multi-center randomized trial of locally advanced esophageal cancer : the Japan Clinical Oncology Group (JCOG) trial 0303 (2011)
  • Author(s): Naoko Sanuki, Satoshi Ishikura, Masayuki Shinoda, Yoshinori Ito, Kazushige Hayakawa, Nobutoshi Ando
  • Journal Title: Int J Clin Oncol Volume: (In press)
  • DOI: 10.1007/s10147-011-0264-9
  • Peer Reviewed
• [Journal Article] Phase I clinical study of NMK36 : a new PET tracer with the synthetic amino acid analogue anti-[(18)F] FACBC (2011)
  • Author(s): Asano Y, Inoue Y, Ikeda Y, Kikuchi K, Hara T, Taguchi C, Tokushige T, Maruo H, Takeda T, Nakamura T, Fujita T, Kumagai Y, Hayakawa K
  • Journal Title: Ann Nucl Med Volume: 25(6) Pages: 414-418
  • DOI: 10.1007/s12149-011-0477-z
  • Peer Reviewed
• [Journal Article] JSMP Guideline of Tissue Inhonogeneneity Corrections for Photon Dose Calculations (2011)
  • Author(s): H.Mizuno, H.Igarashi, H.Okamoto, S.Kameoka, Y.Kumazaki, M.Kurooks, R.Kohno, K.Sasaki, Y.Takahashi, H.Tachibana, T.Nishio, T.Miyagishi, Y.Hanyuu, N.Masai, T.Minemura S.Mori
  • Journal Title: Jpn.J.Med.Phys. Volume: 31 Supple.5 Pages: 1-95
  • Peer Reviewed
• [Journal Article] Development of activity pencil beam algorithm using measured distribution data of positron emitter nuclei generated by proton irradiation of targets containing ^<12>C, ^<16>O and ^<40>Ca nuclei in preparation of clinical application (2011)
  • Author(s): A.Miyatake, T.Nishio, T.Ogino
  • Journal Title: Med.Phys. Volume: 38(10) Pages: 5818-5829
  • DOI: 10.118/1.3641829
  • Peer Reviewed
• [Journal Article] Proton beam therapy as a nonsurgical approach to mucosal melanoma of the head and neck : a pilot study (2011)
  • Author(s): S.Zenda, M.Kawashima, T.Nishio, R.Kohno, K.Nihei, M.Onozawa, S.Arahira, T.Ogino
  • Journal Title: Int.J.Radiat.Oncol.Biol.Phys. Volume: 81(1) Pages: 135-139
  • DOI: 10.1002/hed.21934
  • Peer Reviewed
• [Journal Article] Multi-institutional retrospective analysis of the inhomogeneity correction for radiation therapy of lung cancer (2011)
  • Author(s): H.Mizuno, H.Okamoto, M.Fukuoka, Y.Hanyu, M.Kurooka, R.Kohno, T.Nishio, Y.Kumazaki, H.Tachibana, Y.Takahashi, S.Mori, N.Masai. K.Sasaki
  • Journal Title: J.Radiat.Res. Volume: 52 Pages: 69-74
  • Peer Reviewed
• [Journal Article] A feasibility study of a molecular-based patient setup verification method using a parallel-plane PET system (2011)
  • Author(s): S.Yamaguchi, M.Ishikawa, G.Bengua, K.Sutherland, T.Nishio, S.Tanabe, N.Miyamoto, R.Suzuki, H.Shirato
  • Journal Title: Phys.Med.Biol. Volume: 56 Pages: 965-977
  • DOI: 10.1088/0031-9155/56/4/006
  • Peer Reviewed
• [Journal Article] Dose-volume histgram analysis of the safety of proton beam therapy for unresectable hepatocellular carcinoma (2011)
  • Author(s): M.Kawashima, R.Kohno, K.Nakachi, T.Nishio, S.Mitusnaga, M.Ikeda, M.Konishi, S.Takahasi, N.Gotohda, S.Arahira, S.Zenda, T.Ogino, T.Kinoshita
  • Journal Title: Int.J.Radiat.Oncol.Biol.Phys. Volume: 79(5) Pages: 1479-1486
  • DOI: 10.1016/j.ijrobp.2009.12.048
  • Peer Reviewed
• [Journal Article] Proton dose distribution measurements using a MOSFET detector with a simple dose-weighted correction meathod for LET effect (2011)
  • Author(s): R.Kohno, K.Hotta, T.Matsuura, K.Matsubara, S.Nishioka, T.Nishio, M.Kawashima, T.Ogino
  • Journal Title: J.Appl.Clin.Med.Phys. Volume: 12(2) Pages: 326-337
  • Peer Reviewed
• [Presentation] 陽子線治療の医学物理研究に求められること (2012)
  • Author(s): 西尾禎治
  • Organizer: 第3回バイオイメージインターフェース・ワークショップ
  • Place of Presentation: 宮古島中央公民館(沖縄)(招待講演)
  • Year and Date: 20120224-20120227
• [Presentation] 時間の脳内表現 (2012)
  • Author(s): 田中真樹
  • Organizer: 2011年度日本神経学会北海道地区生涯教育講演会
  • Place of Presentation: 北海道大学医学部臨床大講堂(札幌市)(招待講演)
  • Year and Date: 2012-03-04
• [Presentation] 非小細胞肺癌I期症例に対する動体追跡を用いた定位放射線照射の治療成績 (2012)
  • Author(s): 早田格、早川和重、新部譲、石山博條、小谷承子、関口茜衣、井川聡、三藤久、片桐真人、益田典幸
  • Organizer: 第24回日本高精度放射線外部照射研究会
  • Place of Presentation: パシフィコ横浜会議センター(神奈川)
  • Year and Date: 2012-02-04
• [Presentation] 治療計画用CT画像のメタルアーチファクト除去機能ソフトの開発 (2012)
  • Author(s): 西尾禎治、中井陽一、宮武彩、上田隆司
  • Organizer: 第24回日本高精度放射線外部照射研究会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2012-02-04
• [Presentation] 陽子線治療におけるBeam ON-LINE PETシステムの有用性 (2012)
  • Author(s): 西尾禎治
  • Organizer: 平成23度次世代PET研究会
  • Place of Presentation: 放射線医学総合研究所(千葉)
  • Year and Date: 2012-01-27
• [Presentation] X線・陽子線治療用QAツールの研究開発 (2012)
  • Author(s): 西尾禎治
  • Organizer: 第20回都島IGRTセミナー現場から市場へ～物理士主導型開発品のビジネス展望～
  • Place of Presentation: 大阪リバーサイドホテル(大阪)(招待講演)
  • Year and Date: 2012-01-06
• [Presentation] 陽子線の線量測定 (2011)
  • Author(s): 西尾禎治
  • Organizer: 日本放射線腫瘍学会第24回学術大会、ランチョンセミナー
  • Place of Presentation: 神戸ポートピアホテル(兵庫)(招待講演)
  • Year and Date: 20111117-20111119
• [Presentation] 治療計画用CT画像のメタルアーチファクト除去法の研究 (2011)
  • Author(s): 西尾禎治、中井陽一、宮岸朋子、上田隆司
  • Organizer: 日本放射線腫瘍学会第24回学術大会
  • Place of Presentation: 神戸ポートピアホテル(兵庫)
  • Year and Date: 20111117-20111119
• [Presentation] 線量勾配を考慮した新しい線量分布検証法の開発 (2011)
  • Author(s): 石川正純、Kenneth Sutherland、棚邊哲史、遠山尚紀、成田雄一郎、峯村俊行、西尾禎治、宮本直樹、鈴木隆介、石倉聡
  • Organizer: 日本放射線腫瘍学会第24回学術大会
  • Place of Presentation: 神戸ポートピアホテル(兵庫)
  • Year and Date: 20111117-20111119
• [Presentation] 陽子線スキャニング治療計画の症例データへのシミュレーション評価 (2011)
  • Author(s): 宮永裕樹、中野能行、山田学、西尾禎治
  • Organizer: 日本放射線腫瘍学会第24回学術大会
  • Place of Presentation: 神戸ポートピアホテル(兵庫)
  • Year and Date: 20111117-20111119
• [Presentation] 3軸方向高精度位置制御動体ファントムによる多列4DCTの精度検証と比較 (2011)
  • Author(s): 西島陽祐、水野和恵、ソンユーリン、オブスメアセフィリーノ、西山史朗、西尾禎治、出町和之、上坂充
  • Organizer: 日本放射線腫瘍学会第24回学術大会
  • Place of Presentation: 神戸ポートピアホテル(兵庫)
  • Year and Date: 20111117-20111119
• [Presentation] 陽子線でのEBT2及びEBT3の使用経験 (2011)
  • Author(s): 西尾禎治
  • Organizer: 日本放射線腫瘍学会課題別研究:ガフクロ研究会
  • Place of Presentation: 神戸ポートピアホテル(兵庫)(招待講演)
  • Year and Date: 20111117-20111119
• [Presentation] 医学物理士の役割 (2011)
  • Author(s): 西尾禎治
  • Organizer: 第5回がんプロアカデミアシンポジウム-立教大学理学部医学物理士養成プログラム公開講演会
  • Place of Presentation: 神戸ポートピアホテル(兵庫)(招待講演)
  • Year and Date: 20111117-20111119
• [Presentation] A Simulation Study of Radiation Therapy Based on LQ Model (2011)
  • Author(s): Naoki Kishimoto, Yuriko Komiya, Hiroyuki Date, Hiroki Shirato, Masahiro Mizuta
  • Organizer: Joint Meeting of the Korea-Japan Conference of Comput ational Statistics and the 25th Symposium of Japanese Society of Computational Statistics
  • Place of Presentation: Haeundae Grand Hotel (Korea)
  • Year and Date: 20111111-20111112
• [Presentation] 当科で放射線治療を施行した頭頸部原発小細胞癌症例の検討 (2011)
  • Author(s): 西川由記子、安田耕一、土屋和彦、鬼丸力也、白土博樹、本間明宏、竹内啓、田口純
  • Organizer: 第125回 日本医学放射線学会北日本地方会
  • Place of Presentation: 艮陵会館(宮城)
  • Year and Date: 20111014-20111015
• [Presentation] Theoretical Comparison between Availabilities of Single- and Fractionated- Irradiation Therapies (2011)
  • Author(s): M.Mizuta, S.Takao, H.Date, N.Kishimoto. H.Shirato
  • Organizer: ASTRO's (American Society for Radiation Oncology) 53rd Annual Meeting
  • Place of Presentation: Miami Convention Center Miami Beach (USA)
  • Year and Date: 20111002-20111006
• [Presentation] Proton treatment planning system in National Cancer Center Hospital East (2011)
  • Author(s): T.Nishio
  • Organizer: Pre-congress, Symposia, Lecture, the 6^<th> JSMP-KSMP/11^<th> AOCMP Meeting
  • Place of Presentation: 九州大学医学部100年講堂(福岡市)(招待講演)
  • Year and Date: 20110929-20111001
• [Presentation] Experimental evaluation of a spatial re-sampling technique to improve the dosimetric calculation accuracy of pencil-beam for in proton therapy (2011)
  • Author(s): Y.Egashira, T.Nishio, T.Matuura S.Kameoka, M.Uesaka
  • Organizer: Young Investigator Symposium, the 6^<th> JSMP-KSMP/11^<th> AOCMP Meeting
  • Place of Presentation: 九州大学医学部100年講堂(福岡市)
  • Year and Date: 20110929-20111001
• [Presentation] A New System To Confirm Of Raster-scanning Irradiation Accuracy For Proton Therapy (2011)
  • Author(s): S.Nakamura, H.Takei, Y.Aoyama, S.Akita, H.Asai, Y.Kamikubo, J.Yokosawa, K.Maruyama, S.Tomori, T.Nishio, Y.Sugama, R.Noguchi, K.Hayakawa
  • Organizer: The 6^<th> JSMP-KSMP/11^<th> AOCMP Meeting
  • Place of Presentation: 九州大学医学部100年講堂(福岡市)
  • Year and Date: 20110929-20111001
• [Presentation] Relationship between sensitive volume of ionization chamber and beam spot size in measurement of the proton pencil beam dose distribution (2011)
  • Author(s): Y.Sugama, S.Tomori, S.Nakamura, T.Nishio
  • Organizer: The 6^<th> JSMP-KSMP/11^<th> AOCMP Meeting
  • Place of Presentation: 九州大学医学部100年講堂(福岡市)
  • Year and Date: 20110929-20111001
• [Presentation] Microdosimetric Kinetic Analysis of the Relation between Energy Distribution of Photon Beam and Lesions Induced in Bio-Cells (2011)
  • Author(s): Y.Ohtsubo, K.Tsutsumi, K.Sasaki, K.Wakui, H.Date
  • Organizer: The 6^<th> Japan-Korea Joint Meeting on Medical Physics and the 11^<th> Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka (Japan)
  • Year and Date: 20110928-20111001
• [Presentation] Modeling of Clustering Properties of the Electron Processes in Bio-Tissues Exposed to Ionizing Radiation (2011)
  • Author(s): Yuji Yoshii, Kohei Sasaki, K.L.Sutherland, Hiroyuki Date
  • Organizer: The 6^<th> Japan-Korea Joint Meeting on Medical Physics and the 11^<th> Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka (Japan)
  • Year and Date: 20110928-20111001
• [Presentation] Trial Study of a New Model for Cell Surviving Fraction (2011)
  • Author(s): Kosuke Wakui, Takahiro Kato, Kohei Sasaki, Hiroyuki Date
  • Organizer: The 6^<th> Japan-Korea Joint Meeting on Medical Physics and the 11^<th> Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka (Japan)
  • Year and Date: 20110928-20111001
• [Presentation] MRI上、子宮体癌との鑑別が問題となった子宮放線菌症の一例 (2011)
  • Author(s): 加藤扶美、加藤達也、小田切哲二、久保田佳奈子、渡利英道、三村理恵、真鍋徳子、小野寺祐也、金内優典、櫻木範明、寺江聡、白土博樹
  • Organizer: JASWI 2011
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫)
  • Year and Date: 20110902-20110903
• [Presentation] Microdosimetric Kinetic Analysis of the Lesions in Bio-Cells by Radiation Exposure (2011)
  • Author(s): Y.Ohtsubo, K.Tsutsumi, K.Sasaki, K.Wakui, H.Date
  • Organizer: 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: The Palace of Culture and Science (Poland)
  • Year and Date: 20110828-20110901
• [Presentation] Computational Approach for Determining the Properties of Low-Energy Electron Track (2011)
  • Author(s): Y.Yoshii, K.Sasaki, K.L.Sutherland, H.Date
  • Organizer: 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: The Palace of Culture and Science (Poland)
  • Year and Date: 20110828-20110901
• [Presentation] Spatial re-sampling of pencil beams to improve the dose-calculation accuracy in proton therapy (2011)
  • Author(s): Y.Egashira, T.Nishio, T.Matuura, S.Kameoka, M.Uesaka
  • Organizer: 2011 Joint AAPM/COMP Meeting
  • Place of Presentation: Convention Center (Canada)
  • Year and Date: 20110731-20110804
• [Presentation] Independent quality control and quality assurance programes for IMRT (2011)
  • Author(s): T.Minemura, Y.Narita, M.Ishikawa, S.Ozawa, T.Miyagishi, T.Nishio
  • Organizer: 2011 Joint AAPM/COMP Meeting
  • Place of Presentation: Convention Center (Canada)
  • Year and Date: 20110731-20110804
• [Presentation] 標的原子核破砕反応による線量照射誘導陽子線治療 (2011)
  • Author(s): 西尾禎治
  • Organizer: RCNP核データ研究戦略検討会
  • Place of Presentation: 大阪大学RCNP(大阪)
  • Year and Date: 20110628-20110629
• [Presentation] US-CT統合画像を用いた経皮的ドレナージカテーテル留置の試み (2011)
  • Author(s): 作原祐介、阿保大介、長谷川悠、曽山武士、清水匡、白土博樹、寺江聡
  • Organizer: 第40回日本IVR学会総会
  • Place of Presentation: 青森市文化会館、ホテル青森(青森)
  • Year and Date: 20110519-20110521
• [Presentation] A spatial re-sampling method to improve the accuracy of pencil beam dose calcu lation for proton therapy (2011)
  • Author(s): Y.Egashira, T.Nishio, S.Kameoka, T.Matsuura, M.Uesaka
  • Organizer: PTCOG 50
  • Place of Presentation: Marriott Philadelphia Downtown Hotel (USA)
  • Year and Date: 20110512-20110514
• [Presentation] Development of advanced control system for pencil beam scanning (2011)
  • Author(s): J.Inoue, M.Tachibana, T.Ochi, T.Morita, T.Tachikawa, T.Asaba, T.Nishio, T.Ogino
  • Organizer: PTCOG 50
  • Place of Presentation: Marriott Philadelphia Downtown Hotel (USA)
  • Year and Date: 20110512-20110514
• [Presentation] A calculation method of the beam scanning speed for line scanning method (2011)
  • Author(s): H.Miyanaga, Y.Nakano, M.Yamada, T.Nishio, T.Ogino
  • Organizer: PTCOG 50
  • Place of Presentation: Marriott Philadelphia Downtown Hotel (USA)
  • Year and Date: 20110512-20110514
• [Presentation] 3D irradiation of pencil beam for proton therapy (2011)
  • Author(s): T.Tachikawa, T.Asaba, T.Ochi, M.Yamada, H.Miyanaga, T.Nishio, T.Ogino
  • Organizer: PTCOG 50
  • Place of Presentation: Marriott Philadelphia Downtown Hotel (USA)
  • Year and Date: 20110512-20110514
• [Presentation] 非浸潤性乳管癌の3T MRIにおける画像所見の検討 (2011)
  • Author(s): 加藤扶美、大山徳子、細田充主、寺江聡、高橋弘昌、水戸寿々子、石坂欣也、小野寺祐也、神島保、白土博樹
  • Organizer: 第70回 日本医学放射線学会総会
  • Place of Presentation: (Web開催)
  • Year and Date: 20110509-20110520
• [Presentation] 画像誘導局所Boostを併用した局所進行膀胱癌に対する根治的放射線治療 (2011)
  • Author(s): 西岡健太郎、清水伸一、大坂康博、西川昇、喜多村圭、佐澤陽、篠原信雄、白土博樹
  • Organizer: 第70回 日本医学放射線学会総会
  • Place of Presentation: (Web開催)
  • Year and Date: 20110509-20110520
• [Presentation] valuation of myocardial infarction using fast strain-encoded MRI at 3.0 Tesla (2011)
  • Author(s): 大山徳子、杉森博行、加藤扶美、神島保、小野寺祐也、寺江聡、白土博樹
  • Organizer: 第70回 日本医学放射線学会総会
  • Place of Presentation: (Web開催)
  • Year and Date: 20110509-20110520
• [Presentation] Ethanolによる経皮経肝的門脈塞栓術の検討 (2011)
  • Author(s): 作原祐介,阿保大介,長谷川悠,清水匡,福森大介,神山俊哉, 川村武史, 平野聡, 白土博樹, 寺江聡
  • Organizer: 第70回 日本医学放射線学会総会
  • Place of Presentation: (Web開催)
  • Year and Date: 20110509-20110520
• [Presentation] 3T装置での脳転移スクリーニングのための造影3D-MRIの撮像法の検討:T1-VISTA法とT1-FLAIR法との比較 (2011)
  • Author(s): 吉田篤司、Tha Khin Khin、塚原亜希子、吉田大介、曽山武士、原田慶一、財津有里、藤間憲幸、寺江聡、白土博樹
  • Organizer: 第70回 日本医学放射線学会総会
  • Place of Presentation: (Web開催)
  • Year and Date: 20110509-20110520
• [Presentation] 乳房温存術後の全乳房照射における接線照射と強度変調放射線治療との比較 (2011)
  • Author(s): 土屋和彦、木下留美子、清水伸一、原田慶一、白土博樹
  • Organizer: 第70回 日本医学放射線学会総会
  • Place of Presentation: (Web開催)
  • Year and Date: 20110509-20110520
• [Presentation] 多施設線量管理用物理QCシステムの開発 (2011)
  • Author(s): 西尾禎治、宮岸朋子、石川正純、小澤修一、成田雄一郎、峯村俊行
  • Organizer: 日本医学物理学会第101回学術大会
  • Place of Presentation: (WEB開催)
  • Year and Date: 20110509-20110520
• [Presentation] アクティビティペンシルビーム法による用船照射領域可視化シミュレーションの研究 (2011)
  • Author(s): 宮武彩、西尾禎治、荻野尚
  • Organizer: 日本医学物理学会第101回学術大会
  • Place of Presentation: (WEB開催)
  • Year and Date: 20110509-20110520
• [Presentation] Beam ON-LINE PET systemを利用した腫瘍の線量応答性の研究 (2011)
  • Author(s): 西尾禎治、宮武彩、中川恵一
  • Organizer: 日本医学物理学会第101回学術大会
  • Place of Presentation: (WEB開催)
  • Year and Date: 20110509-20110520
• [Presentation] 陽子線治療のラスタースキャニング照射法におけるビーム走査の精度確認の技術の開発 (2011)
  • Author(s): 戸森聖治、飯塚正樹、須釜裕也、竹中重治、渡邉哲也、武居秀行、西尾禎治、浅羽徹、川畑徹、丸山浩一
  • Organizer: 日本医学物理学会第101回学術大会
  • Place of Presentation: (WEB開催)
  • Year and Date: 20110509-20110520
• [Presentation] 頭頸部がんの陽子線治療計画に対する簡易モンテカルロ法による線量計算 (2011)
  • Author(s): 河野良介、堀田健二、全田貞幹、松原佳奈、丹正亮平、西岡史絵、西尾禎治、河島光彦、荻野尚
  • Organizer: 日本医学物理学会第101回学術大会
  • Place of Presentation: (WEB開催)
  • Year and Date: 20110509-20110520
• [Presentation] Analysis for distribution valued dissimilarity data (2011)
  • Author(s): Masahiro Mizuta
  • Organizer: Joint Meeting of The 2011 Taipei International Statistical Symposium and 7th Conference of the Asian Regional Section of the IASC
  • Place of Presentation: Academia Sinica (Taiwan)(招待講演)
  • Year and Date: 2011-12-17
• [Presentation] Substrate stiffness regulates NF-k B expression and activity in cancer cells (2011)
  • Author(s): S.Ishihara, M.Yasuda, T.Mizutani, K.Kawabata, H.Haga
  • Organizer: 第51回米国細胞生物学会年会
  • Place of Presentation: Colorado Convention Center (USA)
  • Year and Date: 2011-12-03
• [Presentation] 小脳による時間表現 (2011)
  • Author(s): 田中真樹
  • Organizer: 第9回北海道大学脳科学研究教育センターシンポジウム「高次脳機能のメカニズム」
  • Place of Presentation: 北海道大学医学部学友会館(札幌市)(招待講演)
  • Year and Date: 2011-12-02
• [Presentation] Neural mechanism of timing : a role for the cerebellum (2011)
  • Author(s): Tanaka, M
  • Organizer: David Mahoney Center Laboratory Seminar
  • Place of Presentation: Columbia University Medical Center (USA)(招待講演)
  • Year and Date: 2011-11-17
• [Presentation] Manipulation of target choice for covert tracking by electrical microstimulation in the primate frontal eye fields (2011)
  • Author(s): Matsushima A., Tanaka M
  • Organizer: 2011北米神経科学学会
  • Place of Presentation: Washington Convention Center (USA)
  • Year and Date: 2011-11-15
• [Presentation] Encoding of repetitive event timing by sensory gain modulation in the primate deep cerebellar nuclei (2011)
  • Author(s): Ohmae A., Uematsu A., Tanaka M
  • Organizer: 2011北米神経科学学会
  • Place of Presentation: Washington Convention Center (USA)
  • Year and Date: 2011-11-15
• [Presentation] 国立がん研究センター東病院の陽子線治療施設運用について (2011)
  • Author(s): 西尾禎治
  • Organizer: 第26回粒子線がん治療等に関する施設研究会、第35回普及用小型医療加速器を用いた粒子線がん治療施設普及方策検討会
  • Place of Presentation: 日本消防会館(東京)(招待講演)
  • Year and Date: 2011-11-07
• [Presentation] IGRTにPETを用いるための基礎研究。シンポジウム 高精度放射線治療におけるPET/CTの役割 (2011)
  • Author(s): 久下裕司
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場(茨城)(招待講演)
  • Year and Date: 2011-10-29
• [Presentation] Analysis of Symbolic Data with Functional Data Analysis (2011)
  • Author(s): Masahiro Mizuta
  • Organizer: Theory and Application of High-dimensional Complex and Symbolic Data Analysis in Economics and Management Science
  • Place of Presentation: Beihang University (China)(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] Novel noninvasive imaging of the Period 1 gene expression in freely moving mice (2011)
  • Author(s): Hamada, T., S.Honma, K.Sutherland, N.Miyamoto, M.Ishikawa, H.Shirato, K.Honma
  • Organizer: Satellite Symposium of Worldsleep2011 on Human Circadian Clock
  • Place of Presentation: Keio Plaza Hotel, Sapporo, Hokkaido (Japan)
  • Year and Date: 2011-10-22
• [Presentation] 絶対わかる!高精度放射線治療 (2011)
  • Author(s): 沖本智昭
  • Organizer: 第47回日本医学放射線学会秋季臨床大会研修医セミナー
  • Place of Presentation: 海峡メッセ下関(山口県)
  • Year and Date: 2011-10-22
• [Presentation] 非小細胞肺癌に対する定位放射線治療(シンポジウム4「肺癌の低侵襲治療」) (2011)
  • Author(s): 早川和重
  • Organizer: 第47回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 海峡メッセ下関(山口)(招待講演)
  • Year and Date: 2011-10-22
• [Presentation] Mammalian circadian clocks detecting morning light and evening lights. Symposium "Seasonality in sleep and circadian rhythms" (2011)
  • Author(s): Honma S, Yoshikawa T, Ken-ichi Honma K
  • Organizer: 6th World congress of the World Sleep Federation, World Sleep 2011
  • Place of Presentation: Kyoto International Conference Center (Japan)(招待講演)
  • Year and Date: 2011-10-20
• [Presentation] NF-k B expression in cancer cells regulated by substrate stiffness (2011)
  • Author(s): 石原誠一郎、安田元昭、水谷武臣、川端和重、芳賀永
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-03
• [Presentation] EGF刺激による乳癌細胞浸潤におけるAMAP1の詳細な作用機構 (2011)
  • Author(s): 小野寺康仁
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-03
• [Presentation] In vivo bioluminescence reporter gene imaging in freely moving mice (2011)
  • Author(s): Hamada, T., S.Honma, K.Sutherland, N.Miyamoto, M.Ishikawa, H, Shirato, K.Honma
  • Organizer: The 9th International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: Hokkaido University, Sapporo, Hokkaido (Japan)
  • Year and Date: 2011-09-30
• [Presentation] 軟らかい基質がもたらす上皮細胞集団の協調運動 (2011)
  • Author(s): 芳賀永
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 旭川市大雪クリスタルホール(北海道)(招待講演)
  • Year and Date: 2011-09-23
• [Presentation] Manipulation of top-down signals for covert object tracking by electrical stimulation in the primate prefrontal cortex.(サル前頭前野電気刺激による物体の内的追跡に関わるトップダウン信号の操作) (2011)
  • Author(s): Matsushima A., Tanaka M
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-17
• [Presentation] Detection of single omission in isochronous repetitive stimuli relies on two distinct mechanisms.(繰り返し刺激の欠落には2種類の神経機構が関与する) (2011)
  • Author(s): Ohmae A., Tanaka M
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-17
• [Presentation] 陽子線治療と医学物理士 (2011)
  • Author(s): 西尾禎治
  • Organizer: 中国・四国広域がんプロ養成プログラム医学物理士コースセミナー
  • Place of Presentation: 徳島大学(徳島)(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] 時間感覚の脳内表現 (2011)
  • Author(s): 田中真樹
  • Organizer: 第185回つくば脳科学セミナー
  • Place of Presentation: 筑波大学医学部(つくば市)(招待講演)
  • Year and Date: 2011-09-13
• [Presentation] Recent progress in diagnosis and treatment of early gastric cancer and strategy of elimination of gastric cancer from Japan (2011)
  • Author(s): Kato M
  • Organizer: XXIV^<th> International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
  • Place of Presentation: Trinity CollegeDublin (Ireland)(招待講演)
  • Year and Date: 2011-09-11
• [Presentation] サル前頭眼野の電気刺激による物体選択の操作 (2011)
  • Author(s): 松嶋藻乃, 田中真樹
  • Organizer: 第91回北海道医学大会・日本生理学会北海道地方会
  • Place of Presentation: 札幌医科大学(札幌市)
  • Year and Date: 2011-08-27
• [Presentation] サル小脳歯状核の電気刺激による欠落オドボール検出の促進 (2011)
  • Author(s): 植松明子, 大前彰吾, 田中真樹
  • Organizer: 第91回北海道医学大会・日本生理学会北海道地方会
  • Place of Presentation: 札幌医科大学(札幌市)
  • Year and Date: 2011-08-27
• [Presentation] Cellular rhythms and oscillatory networks in the suprachiasmatic nucleus. Workshop : Emergence of circadian rhythms from the central pacemaker and beyond (2011)
  • Author(s): Honma S
  • Organizer: Workshop : Emergence of circadian rhythms from the central pacemaker and beyond
  • Place of Presentation: Institute of Theoretical Biology (Deutsch land)(招待講演)
  • Year and Date: 2011-08-15
• [Presentation] 高精度陽子線治療 (2011)
  • Author(s): 西尾禎治
  • Organizer: 神戸大学がんプロフェッショナル養成プラン講演
  • Place of Presentation: 神戸大学(神戸)(招待講演)
  • Year and Date: 2011-07-29
• [Presentation] Beam ON-LINE PET systemを用いた標的原子核破砕反応による線量照射誘導陽子線治療の研究 (2011)
  • Author(s): 西尾禎治
  • Organizer: 第1回OpenPET研究会
  • Place of Presentation: 放射線医学総合研究所(千葉)
  • Year and Date: 2011-07-25
• [Presentation] Substrate stiffness regulates NF-k B expression and malignancy in cancer cells (2011)
  • Author(s): 石原誠一郎、安田元昭、水谷武臣、川端和重、芳賀永
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2011-06-27
• [Presentation] Collective behavior of epithelial cells responding to stiffness of the extracellular matrix (2011)
  • Author(s): 芳賀永
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学(札幌市)(招待講演)
  • Year and Date: 2011-06-27
• [Presentation] 陽子線治療におけるON-LINE PET (2011)
  • Author(s): 西尾禎治
  • Organizer: 第10回 化学放射線科学研究会
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2011-06-18
• [Presentation] 放射線治療中の膀胱壁の動きに関する検討 (2011)
  • Author(s): 西岡健太郎、西川由記子、原田慶一、土屋和彦、清水伸一、木下留美子、鬼丸力也、白土博樹
  • Organizer: 第124回 日本医学放射線学会北日本地方会
  • Place of Presentation: アイーナいわて県民情報交流センター(岩手)
  • Year and Date: 2011-06-17
• [Presentation] 眼球運動のタイミング制御における前頭葉背内側部のはたらき (2011)
  • Author(s): 國松淳, 田中真樹
  • Organizer: 第5回生理研Motor Control研究会
  • Place of Presentation: 生理学研究所(愛知)
  • Year and Date: 2011-06-17
• [Presentation] EBUS-GS下生検にて診断し動体追跡放射線照射にて治療した末梢小型肺癌の検討 (2011)
  • Author(s): 竹内裕
  • Organizer: 第34回呼吸器内視鏡学会総会
  • Place of Presentation: アクトシティ浜松(静岡)
  • Year and Date: 2011-06-16
• [Presentation] Potential role of FDG-PET to evaluuate the outcome of post neoadjuvant chemor adiation for locally advanced pancreatic cancer (2011)
  • Author(s): Takei T, Okamoto S, Shiga T, Yasuda K, Hattori N, Tahara M, Nakanishi K, Kamachi H, Kamiyama T, Toda S, Tamaki N
  • Organizer: The 58th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: The H.B.Gonzalez Convention Center (USA)
  • Year and Date: 2011-06-07
• [Presentation] FMISO PET can early evaluate antiangiogenic response to anti-EGFR molecular-targeting therapy (cetuximab) in human lung cancer xenograft (2011)
  • Author(s): Zhao S, Kuge Y, Zhao Y, Takeuchi S, Murakami M, Li H, Nusrat F Chouwdhury, Nishijima K, Dosaka-Akita H, Tamaki N
  • Organizer: The 58th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: The H.B.Gonzalez Convention Center (USA)
  • Year and Date: 2011-06-06
• [Presentation] ^<18>F-FMISO accumulates in gliobalstoma multiforme but not in grade III or less malignant gliomas (2011)
  • Author(s): Hirata K, Hattori N, Shiga T, Usui R, Yamaguchi S, Terasaka S, Narita T, Tanaka S, Kuge Y, Tamaki N
  • Organizer: The 58th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: The H.B.Gonzalez Convention Center (USA)
  • Year and Date: 2011-06-06
• [Presentation] 最新の医学物理関連の話題 (2011)
  • Author(s): 西尾禎治
  • Organizer: 第19回 広島大学病院放射線治療講演会
  • Place of Presentation: 広島大学(広島)(招待講演)
  • Year and Date: 2011-05-26
• [Presentation] 小脳機能の生理学的解析 (2011)
  • Author(s): 田中真樹、大前彰吾、植松明子
  • Organizer: 第52回日本神経学会学術大会シンポジウム「脊髄小脳変性症:update」
  • Place of Presentation: 名古屋国際会議場(愛知)(招待講演)
  • Year and Date: 2011-05-20
• [Presentation] Ebamipide prevents low-dose aspirin-induced small intestinal injuries : a randomized placebo-controlled double-blinded cross-over study using video capsule endoscopy and contrast-enhanced ultrasonography (2011)
  • Author(s): Kato M, Nishida U, Ono S, Mabe K, Shimizu Y, Asaka M
  • Organizer: DDW2011
  • Place of Presentation: Convention center (USA)
  • Year and Date: 2011-05-07
• [Presentation] Changes of endoscopic gastritis after cure of H.pylori infection (2011)
  • Author(s): Kato M, Terao S, Adachi K, Nakajima S, Ando T, Watanabe H, Kato T, Ida K
  • Organizer: DDW2011
  • Place of Presentation: Convention center (USA)
  • Year and Date: 2011-05-07
• [Presentation] Electrical microstimulation in the primate dorsomedial frontal cortex alters the timing of self-initiated saccades (2011)
  • Author(s): Kunimatsu J, Tanaka M
  • Organizer: 国際比較生理生化学会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-05-06
• [Presentation] 頭頸部リンパ節腫瘍における放射線治療効果予測 (2011)
  • Author(s): 高尾聖心, 但野茂, 田口大志, 安田耕一, 鬼丸力也, 石川正純, 鈴木隆介, Bengua Gerard, 白土博樹
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京電機大学(東京都)
  • Year and Date: 2011-04-29
• [Presentation] PETを利用した高精度陽子線治療技術 (2011)
  • Author(s): 西尾禎治
  • Organizer: 平成23年度日本非破壊検査協会特別講演会
  • Place of Presentation: (財)電子科学研究所(大阪)(招待講演)
  • Year and Date: 2011-04-22
• [Book] Oscillator cell networks in the hypothalamic suprachiasmatic nucleus, the mammalian circadian clock. In "Advances inCognitive Neurodynamics (III)" (eds by) T.Omori, Tsukada (2012)
  • Author(s): Honma S, Ono D, Honma k.
  • Publisher: Springer, Tokyo(In press)
• [Book] Suprachiasmatic nucleus : cellular clocks and networks (2012)
  • Author(s): Honma S, Ono D, Suzuki Y, Inagaki N, Yoshikawa T, Nakamura W, Honma K
  • Publisher: Progress in Brain Res(In press)
• [Book] Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy, Applied Biological Engineering-Principles and Practice (2012)
  • Author(s): Takao S, Tadano S, Taguchi H, Shirato H.(分担)
  • Total Pages: 30-46(662)
  • Publisher: InTech
• [Book] Thalamic roles in eye movements In : Oxford Handbook on Eye Movements(S.P. Liversedge, I.D. Glichrist, S. Everling, Eds.), pp. 235-256 (2011)
  • Author(s): Tanaka, M., Kunimatsu, J.
  • Total Pages: 1027
  • Publisher: Oxford University Press, UK
• [Book] 永井厚志,大田健,江口研二,橋本修・編:2011-2012EBM呼吸器疾患の治療 (2011)
  • Author(s): 早川和重(分担)
  • Total Pages: 465-470(総ページ569頁)
  • Publisher: 中外医学社(東京)