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2012 Fiscal Year Annual Research Report

動体追跡医科学研究

Research Project

Project/Area Number 21249065
Research InstitutionHokkaido University

Principal Investigator

白土 博樹  北海道大学, 医学(系)研究科(研究院), 教授 (20187537)

Co-Investigator(Kenkyū-buntansha) 本間 さと  北海道大学, 医学(系)研究科(研究院), 特任教授 (20142713)
玉木 長良  北海道大学, 医学(系)研究科(研究院), 教授 (30171888)
久下 裕司  北海道大学, アイソトープ総合センター, 教授 (70321958)
水田 正弘  北海道大学, 情報科学研究科, 教授 (70174026)
伊達 広行  北海道大学, 保健科学研究院, 教授 (10197600)
田中 真樹  北海道大学, 医学(系)研究科(研究院), 教授 (90301887)
芳賀 永  北海道大学, 先端生命科学研究科(研究院), 准教授 (00292045)
西岡 健  北海道大学, 保健科学研究院, 教授 (80271659)
加藤 元嗣  北海道大学, 大学病院, 准教授 (60271673)
大泉 聡史  北海道大学, 大学病院, 准教授 (10421968)
松永 尚文  山口大学, 医学(系)研究科(研究院), 教授 (40157334)
早川 和重  北里大学, 医学部, 教授 (70114189)
西尾 禎治  独立行政法人国立がん研究センター, 臨床開発センター粒子線医学開発部 粒子線生物学室, 室長 (40415526)
但野 茂  北海道大学, 工学(系)研究科(研究院), 教授 (50175444)
石川 正純  北海道大学, 医学(系)研究科(研究院), 教授 (80314772)
小野寺 康仁  北海道大学, 医学(系)研究科(研究院), 助教 (90435561)
澁谷 景子  山口大学, 医学(系)研究科(研究院), 教授 (50335262)
浜田 俊幸  北海道大学, 医学(系)研究科(研究院), 特任准教授 (20360208)
鬼丸 力也  北海道大学, 医学(系)研究科(研究院), 准教授 (80374461)
清水 伸一  北海道大学, 医学(系)研究科(研究院), 特任准教授 (50463724)
土屋 和彦  北海道大学, 大学病院, 准教授 (60580892)
加藤 徳雄  北海道大学, 大学病院, 助教 (80572495)
木下 留美子  北海道大学, 医学(系)研究科(研究院), 特任助教 (70507582)
井上 哲也  北海道大学, 大学病院, 助教 (10431363)
小野寺 俊輔  北海道大学, 医学(系)研究科(研究院), 特任助教 (30374458)
高尾 聖心  北海道大学, 医学(系)研究科(研究院), 特任助教 (10614216)
加賀 基知三  北海道大学, 大学病院, 講師 (80224335)
Project Period (FY) 2009-04-01 – 2013-03-31
Keywords動体追跡 / 細胞遊走 / 放射線治療 / 胃癌 / 低酸素細胞
Research Abstract

最終年度は、生体の動きを細胞からヒトのあらゆるレベルで、リアルタイムに計測することで、新たな動体追跡医科学という領域を切り開く試みが行われた。1.放射線照射後に生残したヒト肺腺癌由来細胞A549細胞の浸潤能が照射前よりも亢進するメカニズムは、アクチン結合タンパク質の一つであるFilaminBの発現が上昇し、浸潤能の亢進をもたらすことが明らかとなった。2.小動物の追跡を実用可能とする技術的要件を明らかにし、複数同時動体追跡を可能にし、その有効性を明らかにした。長期間覚醒マウスの組織部位からの遺伝子発現を示す発光を2台のカメラで同時に追跡し、かつ発光量を定量する3次元動体追跡法を完成し、覚醒マウスの in vivo 発光イメージングによる遺伝子発現を連続的に長期間計測できる方法が確立された。3.食道、胃、十二指腸の粘膜下層に粘膜下層剥離術の技術を応用して、金ボールマーカーの挿入法を確立。バルーン小腸鏡を活用し、臨床的に胃リンパ腫などを対象に金ボールを埋め込み、合併症なくRTRT施行された。これにより、全消化管に金ボールマーカーの挿入は技術的に可能となり、これまで以上にRTRTの適用が拡大できることが判明した。4.動体追跡照射を行う場合に、Linear-quadratic model (LQ model)を利用した適切な線量分割方法の導出法に関する検討を進め、グラフィカル表示法を開発した。5.実験動物の脳に治療用放射線の定位照射を行い、マカクサルの脳の一部への放射線照射の影響をMRIと行動解析によって追跡調査した例はなく、本研究が世界初の試みとなる。今年度は2頭のサルの前頭眼野を中心とし領域に計3回の照射を行った。照射後数週間は浮腫が著明であり、行動指標として用いた眼球運動にも軽度の変化が認められたが、1か月程度の経過で画像所見、行動ともに照射前のレベルに落ち着いた。

Current Status of Research Progress
Reason

24年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

24年度が最終年度であるため、記入しない。

  • Research Products

    (164 results)

All 2013 2012 Other

All Journal Article (62 results) (of which Peer Reviewed: 60 results) Presentation (96 results) (of which Invited: 17 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Symptomatic Outcomes in Relation to Tumor Expansion After Fractionated Stereotactic Radiation Therapy for Vestibular Schwannomas: Single-Institutional Long-Term Experience2013

    • Author(s)
      Aoyama H, Onodera S, Takeichi N, Onimaru R, Terasaka S, Sawamura Y, Shirato H
    • Journal Title

      Int J Radiat Oncol BiolPhys

      Volume: 1;85(2) Pages: 329-334

    • DOI

      doi:10.1016/j.ijrobp.2012.05.003

    • Peer Reviewed
  • [Journal Article] Irradiation-tolerant Lung Cancer Cells Acquire Invasive Ability Dependent on Dephosphorylation of the Myosin Regulatory Light Chain2013

    • Author(s)
      S. Ishihara, M. Yasuda, T. Nishioka, T. Mizutani, K. Kawabata, H. Shirato and H. Haga
    • Journal Title

      FEBS Letters

      Volume: 587 Pages: 732-736

    • Peer Reviewed
  • [Journal Article] Stereotactic body radiotherapy using gated radiotherapy with real-time tumor-tracking for stage I non-small cell lung cancer2013

    • Author(s)
      Inoue T, Katoh N, Onimaru R, Shimizu S, Tsuchiya K, Suzuki R, Sakakibara-Konishi J, Shinagawa N, Oizumi S, Shirato H
    • Journal Title

      Radiat Oncol

      Volume: 8(1):69 Pages: -

    • DOI

      doi: 10.1186/1748-717X-8-69

    • Peer Reviewed
  • [Journal Article] Contrast-enhanced whole body joint MR Imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system for MR synovitis2013

    • Author(s)
      Kamishima T, Kato M, Atsumi T, Koike T, Onodera Y, Terae S
    • Journal Title

      Clin Exp Rheumatol

      Volume: 31(1) Pages: 154

    • Peer Reviewed
  • [Journal Article] Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain2013

    • Author(s)
      Ishihara S, Yasuda M, Nishioka T, Mizutani T, Kawabata K, Shirato H, Haga H
    • Journal Title

      FEBS Lett

      Volume: 587(6) Pages: 732-736

    • DOI

      doi: 10.1016/j.febslet.2013.01.055

    • Peer Reviewed
  • [Journal Article] Differential responses of circadian Per2 expression rhythms in discrete brain areas to daily injection of methamphetamine and restricted feeding in rats.2013

    • Author(s)
      Natsubori A. et al.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 37 Pages: 251-258

    • DOI

      doi: 10.1111/ejn.12034.

    • Peer Reviewed
  • [Journal Article] Daily exposure to cold phase-shifts circadian clock of neonatal rat in vivo.2013

    • Author(s)
      Yoshikawa T et al.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 37 Pages: 491-497

    • DOI

      doi: 10.1038/embor.2012.37.

    • Peer Reviewed
  • [Journal Article] High reproducibility of tumor hypoxia evaluated by 18F-fluoromisonidazole PET for head and neck cancer.2013

    • Author(s)
      Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato H, Tamaki N
    • Journal Title

      J Nucl Med

      Volume: 54卷 Pages: 201-207

    • DOI

      doi: 10.2967/jnumed.112.109330.

    • Peer Reviewed
  • [Journal Article] Biological characteristics of intratumoral [F-18] fluoromisonidazole distribution in a rodent model of glioma2013

    • Author(s)
      Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki N, Kuge Y
    • Journal Title

      Int J Oncol

      Volume: 42卷 Pages: 823-830

    • DOI

      doi: 10.3892/ijo.2013.1781

    • Peer Reviewed
  • [Journal Article] Monitoring tumor proliferative response to radiotherapy using (18)F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-672013

    • Author(s)
      Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima KI, Tamaki N, Kitagawa Y, Kuge Y
    • Journal Title

      Ann Nucl Med

      Volume: - Pages: -

    • Peer Reviewed
  • [Journal Article] Retrospective and prospective information coding by different neurons in the prefrontal cortex.2013

    • Author(s)
      Matsushima, A. & Tanaka, M.
    • Journal Title

      NeuroReport

      Volume: 24 Pages: 73-78

    • DOI

      doi: 10.1097/WNR.0b013e32835c8d66

    • Peer Reviewed
  • [Journal Article] Manipulation of object choice by electrical microstimulation in macaque frontal eye fields.2013

    • Author(s)
      Matsushima, A. & Tanaka, M.
    • Journal Title

      Cereb. Cortex

      Volume: - Pages: -

    • Peer Reviewed
  • [Journal Article] Changes in Endoscopic Findings of Gastritis after Cure of H. pylori Infection: Multicenter Prospective Tria2013

    • Author(s)
      Kato M, TeraoS, et
    • Journal Title

      Dig Endosc:

      Volume: - Pages: -

    • DOI

      doi: 10.1111/j.1443-1661.2012.01385.x

    • Peer Reviewed
  • [Journal Article] Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.2013

    • Author(s)
      Haneda M, Kato M, Ishigaki S, Suzuki M, Takahashi M, Nakagawa M, Ono S, Mori Y, Mabe K, Kudo T, Nakagawa S, Shimizu Y, Asaka M.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 28 Pages: 78-83

    • DOI

      doi: 10.1111/j.1440-1746.2012.07285.x.

    • Peer Reviewed
  • [Journal Article] Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking- Ultrasonography Test.2013

    • Author(s)
      Hata T. Kato M. Kudo T. Nishida M. Nishida U. Imai A. Yoshida T. Hirota J. Kamada G. Ono S. Nakagawa M. Nakagawa, S. Shimizu, Y. Takeda H. Asaka M.
    • Journal Title

      Digestion

      Volume: 87 Pages: 34-39

    • DOI

      doi:10.1159/000343935

    • Peer Reviewed
  • [Journal Article] Endoscopic resection (endoscopic mucosal resection/ endoscopic submucosal dissection) for superficial esophageal squamous cell carcinoma: Current status of various techniques.2013

    • Author(s)
      Shimizu Y, Takahashi M, Yoshida T, Ono S, Mabe K, Kato M, Asaka M, Sakamoto N.
    • Journal Title

      Digestive Endosc

      Volume: Suppl 1 Pages: 13-19

    • DOI

      doi: 10.1111/j.1443-1661.2012.01408.x

    • Peer Reviewed
  • [Journal Article] Clinical outcome of supracricoid laryngectomy with cricohyoidoepiglottopexy: Radiation failure versus previously untreated patients.2013

    • Author(s)
      Nakayama M, Okamoto M, Hayakawa K, Ishiyama H, Kotani S, Miyamoto S, Seino Y, Okamoto T, Soda I, Sekiguchi A.
    • Journal Title

      Auris Nasus Larynx

      Volume: 40(2): Pages: 207-210

    • DOI

      doi: 10.1016/j.anl.2012.07.014

    • Peer Reviewed
  • [Journal Article] Application of the pencil-beam redefinition algorithm in heterogeneous media for proton therapy2013

    • Author(s)
      Y. Egashira, T. Nishio, K. Hotta, R. Kohno, M. Uesaka
    • Journal Title

      Phys. Med. Biol.

      Volume: 58(4) Pages: 1169-1184

    • DOI

      doi:10.1088/0031-9155/58/4/1169

    • Peer Reviewed
  • [Journal Article] Conceptual design of multi-targets for accelerator-driven system experiments with 100-MeV protons2013

    • Author(s)
      Y. Takahashi, T. Azuma, T. Nishio, T. Yagi, C. H. Pyeon, T. Misawa
    • Journal Title

      Annals of Nuclear Energy

      Volume: 54 Pages: 162-166

    • DOI

      doi: 10.1016/j.anucene.2012.10.018

    • Peer Reviewed
  • [Journal Article] Interfractional dose variations in the stomach and the bowels during breath-hold intensity-modulated radiotherapy for pancreatic cancer: implications for a dose-escalation strategy.2013

    • Author(s)
      Nakamura A, Shibuya K, Nakamura M, Matsuo Y, Shiinoki T, Nakata M, Mizowaki T, Hiraoka M
    • Journal Title

      Medical Physics

      Volume: 40(2) Pages: 121701 1-9

    • DOI

      doi: 10.1118/1.4773033

    • Peer Reviewed
  • [Journal Article] Differences in the dose-volume metrics with heterogeneity correction status and its influence on local control in stereotactic body radiation therapy for lung cancer.2013

    • Author(s)
      Ueki N, Matsuo Y, Shibuya K, Nakamura M, Narabayashi M, Sakanaka K,Norihisa Y, Mizowaki T, Hiraoka M
    • Journal Title

      J Radiat Res

      Volume: 54(2) Pages: 337-343

    • DOI

      doi: 10.1093/jrr/rrs084

    • Peer Reviewed
  • [Journal Article] Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning2012

    • Author(s)
      Masahiro Mizuta, Hiroyuki Date, Seishin Takao, Naoki Kishimoto, Kenneth L. Sutherland, Rikiya Onimaru, and Hiroki Shirato
    • Journal Title

      Medical Physics

      Volume: 39 (11) Pages: 6791-6795

    • DOI

      doi:10.1118/1.4757580

    • Peer Reviewed
  • [Journal Article] Clinical Outcomes of Stereotactic Body Radiotherapy for Patients with Lung Tumors in the State of Oligorecurrence2012

    • Author(s)
      Inoue T, Katoh N, Onimaru R, Shirato H
    • Journal Title

      Pulmonary Medicine

      Volume: 2012:369820 Pages: -

    • DOI

      doi:10.1155/2012/369820

    • Peer Reviewed
  • [Journal Article] Preoperative percutaneous transhepatic portal vein embolization with ethanol injection2012

    • Author(s)
      Sakuhara Y, Abo D, Hasegawa Y, Shimizu T, Kamiyama T, Hirano S, Fukumori D, Kawamura T, Ito YM, Tha KK, Shirato H, Terae S
    • Journal Title

      AJR Am J Roentgenol.

      Volume: 198(4) Pages: 914-922

    • DOI

      doi: 10.2214/AJR.11.6515.

    • Peer Reviewed
  • [Journal Article] Feasibility of a dual microcatheter-dual interlocking detachable coil technique in preoperative embolization in preparation for distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer2012

    • Author(s)
      Abo D, Hasegawa Y, Sakuhara Y, Terae S, Shimizu T, Tha KK, Tanaka E, Hirano S, Kondo S, Shirato H
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 19(4) Pages: 431-437

    • DOI

      doi: 10.1007/s00534-011-0455-9

    • Peer Reviewed
  • [Journal Article] Usefulness of portography and contrast-enhanced computed tomography to predict the embolized area in percutaneous transhepatic portal vein embolization with absolute ethanol under temporary balloon occlusion2012

    • Author(s)
      Hasegawa Y, Abo D, Sakuhara Y, Kato F, Kamishimma T, Shimizu T, Ito YM, Terae S, Shirato H
    • Journal Title

      Jpn J Radiol

      Volume: 30(1) Pages: 53-61

    • DOI

      doi: 10.1007/s11604-011-0008-9

    • Peer Reviewed
  • [Journal Article] Guidelines for respiratory motion management in radiation therapy2012

    • Author(s)
      Matsuo Y, Onishi H, Nakagawa K, Nakamura M, Ariji T, Kumazaki Y, Shimbo M, Tohyama N, Nishio T, Okumura M, Shirato H, Hiraoka M
    • Journal Title

      J Radiat Res

      Volume: - Pages: -

    • Peer Reviewed
  • [Journal Article] Regional control after concomitant chemoradiotherapy without planned neck dissection in node-positive head and neck squamous cell carcinomas2012

    • Author(s)
      Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Kano S, Mizumachi T, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
    • Journal Title

      Auris Nasus Larynx

      Volume: - Pages: -

    • DOI

      doi: 10.1016/j.anl.2012.07.002

    • Peer Reviewed
  • [Journal Article] A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear-Quadratic Model2012

    • Author(s)
      Mizuta M, Takao S, Date H, Kishimoto N, Sutherland KL, Onimaru R, Shirato H
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 84(3) Pages: 829-833

    • DOI

      doi: 10.1016/j.ijrobp.2012.01.004

    • Peer Reviewed
  • [Journal Article] De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide.2012

    • Author(s)
      Nishide S. et al.
    • Journal Title

      Eur J Neurosci

      Volume: 35 Pages: 291-299

    • DOI

      doi: 10.1111/j.1460-9568.2011.07952.x.

    • Peer Reviewed
  • [Journal Article] Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis.2012

    • Author(s)
      Kwon HJ et. al
    • Journal Title

      Cell Death and Disease

      Volume: 3 Pages: e278

    • DOI

      doi: 10.1038

    • Peer Reviewed
  • [Journal Article] JNK regulates the photic response of the mammalian circadian clock.2012

    • Author(s)
      Yoshitane H. et al.
    • Journal Title

      EMBO Report

      Volume: 13 Pages: 455-461

    • DOI

      doi: 10.1038/embor.2012.37.

    • Peer Reviewed
  • [Journal Article] Single-cell resolution fluorescence imaging of circadian rhythms detected with a Nipkow spinning disk confocal system.2012

    • Author(s)
      Enoki R. et al.
    • Journal Title

      J Neurosci Methods

      Volume: 202 Pages: 72-79

    • DOI

      doi: 10.1016/j.jneumeth.2012.03.004.

    • Peer Reviewed
  • [Journal Article] Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus.2012

    • Author(s)
      Enoki R. et al.
    • Journal Title

      Proc. Natl. Acad.Sci USA

      Volume: 109 Pages: 21498-21503

    • DOI

      doi: 10.1038/embor.2012.37.

    • Peer Reviewed
  • [Journal Article] Suprachiasmatic nucleus: cellular clocks and networks.2012

    • Author(s)
      Honma S et al.
    • Journal Title

      Prog Brain Res

      Volume: 199 Pages: 129-141

    • DOI

      pii: S0168-0102(13)00005-9. 10.1016/j.neures

    • Peer Reviewed
  • [Journal Article] 18F-Fluoromisonidazole positron emission tomographymay differentiate glioblastoma multiforme from lessmalignant gliomas2012

    • Author(s)
      Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, Yamaguchi S,Houkin K, Tanaka S, KugeY, Tamaki N
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 39卷 Pages: 760-770

    • DOI

      doi: 10.1007/s00259-011-2037-0

    • Peer Reviewed
  • [Journal Article] Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma2012

    • Author(s)
      Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y
    • Journal Title

      Int J Oncol

      Volume: 41卷 Pages: 1593-1600

    • DOI

      doi: 10.3892/ijo.2012.1624.

    • Peer Reviewed
  • [Journal Article] 医薬品開発(又は創薬・育薬)における分子イメージング技術の現状と進歩2012

    • Author(s)
      久下裕司、西嶋剣一、孫田恵一、趙松吉、玉木長良
    • Journal Title

      医薬品医療機器レギュラトリーサイエンス

      Volume: 43卷 Pages: 308-313

  • [Journal Article] A Mathematical Study to Select Fractionation Regimen based on Physical Dose Distribution and the Linear-Quadratic Model,2012

    • Author(s)
      M. Mizuta, S. Takao, H. Date, N. Kishimoto, K. L. Sutherland,R. Onimaru, and H. Shirato
    • Journal Title

      International Journal of Radiation Oncology, Biology

      Volume: Vol.84, No.3 Pages: 829-833

    • DOI

      doi:10.1016/j.ijrobp.2012.01.004

    • Peer Reviewed
  • [Journal Article] Graphical Representation of the Effects on Tumor and OAR for Determining the Appropriate Fractionation Regimen in Radiation Therapy Planning2012

    • Author(s)
      M. Mizuta, H. Date, S. Takao, N. Kishimoto, K. L. Sutherland,R. Onimaru, H. Shirato
    • Journal Title

      Medical Physics

      Volume: Vol.39, No.11 Pages: 6791-6795

    • DOI

      doi: 10.1118/1.4757580

    • Peer Reviewed
  • [Journal Article] A Simulation Study of the Radiation-Induced Bystander Effect: Modeling with Stochastically Defined Signal Reemission2012

    • Author(s)
      Kohei Sasaki, Kosuke Wakui, Kaori Tsutsumi, Akio Itoh, and Hiroyuki Date
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: 2012 Pages: 5 pages

    • DOI

      doi:10.1155/2012/389095

    • Peer Reviewed
  • [Journal Article] Investigation of the change in marker geometry during respiration motion: a preliminary study for dynamic-multi-leaf real-time tumor tracking2012

    • Author(s)
      Rie Yamazaki, Seiko Nishioka, Hiroyuki Date, Hiroki Shirato, Takao Koike, and Takeshi Nishioka
    • Journal Title

      Radiation Oncology

      Volume: 7:218 Pages: 5 pages

    • DOI

      doi:10.1186/1748-717X-7-218

    • Peer Reviewed
  • [Journal Article] Neuronal correlates of multiple top-down signals during covert tracking of moving objects in macaque prefrontal cortex.2012

    • Author(s)
      Matsushima, A. & Tanaka, M.
    • Journal Title

      J. Cogn. Neurosci.

      Volume: 24 Pages: 2043-2056

    • DOI

      doi: 10.1162/jocn_a_00265

    • Peer Reviewed
  • [Journal Article] Alteration of the timing of self-initiated but not reactive saccades by electrical stimulation in the supplementary eye field.2012

    • Author(s)
      Kunimatsu, J. & Tanaka, M.
    • Journal Title

      Eur. J. Neurosci.

      Volume: 36 Pages: 3258-3268

    • DOI

      doi: 10.1111/j.1460-9568.2012.08242.x

    • Peer Reviewed
  • [Journal Article] 視床-大脳皮質経路による運動の制御:ニホンザルの眼球運動を指標とした研究(Role of the primate thalamocortical pathways in the generation of eye movements.)2012

    • Author(s)
      國松 淳、田中真樹
    • Journal Title

      比較生理生化学会誌

      Volume: 29 Pages: 235-241

    • Peer Reviewed
  • [Journal Article] The Number of Cyclic Stretch Regulates Cellular Elasticity in C2C12 Myoblasts2012

    • Author(s)
      K. Takemoto, T. Mizutani, K. Tamura, K. Takeda, H. Haga, K. Kawabata
    • Journal Title

      Open Journal of Cell Biology

      Volume: 2 Pages: 1-10

    • DOI

      doi: 10.4236/cellbio.2012.11001

    • Peer Reviewed
  • [Journal Article] Investigation of the change in marker geometry during respiration motion: a preliminary study for dynamic-multi-leaf real-time tumor tracking.2012

    • Author(s)
      Yamazaki R, Nishioka S, Date H, Shirato H, Koike T, Nishioka T.
    • Journal Title

      Radiation Oncology.

      Volume: 18 Pages: 218-222

    • DOI

      doi:10.1186/1748-717X-7-218

    • Peer Reviewed
  • [Journal Article] Recent Develop -ment of Gastric Cancer Prevention2012

    • Author(s)
      Kato M, Asaka M.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 42 Pages: 987-994

    • DOI

      doi: 10.1093/jjco/hys151.

    • Peer Reviewed
  • [Journal Article] Relationship between Diffusion-Weighted Magnetic Resonance Imaging and Histological Tumor Grading of Hepatocellular Carcinoma2012

    • Author(s)
      Nakanishi M, Chuma M, Hige S, Omatsu T, Yokoo H, Nakanishi K, Kamiyama T, Kubota K, Haga H, Matsuno Y, Onodera Y, Kato M, Asaka M.
    • Journal Title

      Ann Surg Oncol

      Volume: 19 Pages: 1302-1309

    • DOI

      doi: 10.1245/s10434-011-2066-8.

    • Peer Reviewed
  • [Journal Article] Efficacy of carbon dioxide-insufflating colonoscopy in patients with irritable bowel syndrome (IBS): a randomized double-blind study.2012

    • Author(s)
      Imai A, Kato M, Ono S, Shimizu Y, Takeda H, Asaka M.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 27 Pages: 1623-1628

    • DOI

      doi: 10.1111/j.1440-1746.2012.07208.x

    • Peer Reviewed
  • [Journal Article] Coccoid Helicobacter pylori Can Directly Adhere and Invade in Agminated Formation to Human Gastric Epithelial Cells.2012

    • Author(s)
      Saito N, Ooi HK, Konishi K, Shoji E, Kato M, Asaka M
    • Journal Title

      Advances in Microbiology

      Volume: 2 Pages: 112-116

    • DOI

      doi:10.4236/aim.2012.22015

    • Peer Reviewed
  • [Journal Article] Frequency of Helicobacter pylori -Negative Gastric Cancer and Gastric Mucosal Atrophy in a Japanese Endoscopic Submucosal Dissection Series Including Histological, Endoscopic and Serological Atrophy.2012

    • Author(s)
      Ono S, Kato M, Suzuki M, Ishigaki S, Takahashi M, Haneda M, Mabe K, Shimizu Y.
    • Journal Title

      Digestion

      Volume: 86 Pages: 59-65

    • DOI

      doi: 10.1159/000339176.

    • Peer Reviewed
  • [Journal Article] Phase I results of vinorelbine with concurrent radiotherapy in elderly patients with unresectable, locally advanced non-small-cell lung cancer: West Japan Thoracic Oncology Group (WJTOG3005-DI).2012

    • Author(s)
      Harada H, Seto T, Igawa S, Tsuya A, Wada M, Kaira K, Naito T, Hayakawa K, Nishimura T, Masuda N, Yamamoto N.
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 82(5) Pages: 1777-1782

    • DOI

      doi: 10.1016/j.ijrobp.2011.03.037

    • Peer Reviewed
  • [Journal Article] Diffusion-weighted imaging of local recurrent prostate cancer after radiation therapy: comparison with 22-core three-dimensional prostate mapping biopsy.2012

    • Author(s)
      Hara T, Inoue Y, Satoh T, Ishiyama H, Sakamoto S, Woodhams R, Baba S, Hayakawa K.
    • Journal Title

      Magn Reson Imaging.

      Volume: 30(8) Pages: 1091-1098

    • DOI

      doi: 10.1016/j.mri.2012.04.022.

    • Peer Reviewed
  • [Journal Article] Huidelines for respiratory motion management in radiation therapy2012

    • Author(s)
      Y. Matsuo, H. Onishi, K. Nakagawa, M. Nakamura, T. Ariji, Y. Kumazaki, M. Shimbo, N. Tohyama, T. Nishio, M. Okumura, H. Shirato, M. Hiraoka
    • Journal Title

      J. Rad. Res.

      Volume: - Pages: -

    • DOI

      doi: 10.1093/jrr/rrs122

    • Peer Reviewed
  • [Journal Article] Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignacies2012

    • Author(s)
      H. Hojo, S. Zenda, T. Akimoto, R. Kohno, M. Kawashima, S. Arahira, T. Nishio, M. Tahara, R. Hayashi, K. Sasai
    • Journal Title

      J. Radiat. Res.

      Volume: 53 Pages: 704-709

    • DOI

      doi: 10.1093/jrr/rrs021

    • Peer Reviewed
  • [Journal Article] Experimental evaluation of a spatial resampling technique to improve the accuracy of pencil-beam dose calculation in proton therapy2012

    • Author(s)
      Y. Egashira, T. Nishio, T. Matsuura, S. Kameoka, M. Uesaka
    • Journal Title

      Med. Phys.

      Volume: 39(7) Pages: 4104-4114

    • DOI

      doi: 10.1118/1.4722984

    • Peer Reviewed
  • [Journal Article] Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.2012

    • Author(s)
      Onodera Y, Nam JM, Hashimoto A, Norman JC, Shirato H, Hashimoto S, Sabe H
    • Journal Title

      The Journal of Cell Biology

      Volume: 197 Pages: 983-996

    • DOI

      doi: 10.1083

    • Peer Reviewed
  • [Journal Article] Analysis of dosimetric parameters associated with acute gastrointestinal toxicity and upper gastrointestinal bleeding in locally advanced pancreatic cancer patients treated with gemcitabine-based concurrent chemoradiotherapy.2012

    • Author(s)
      Nakamura A, Shibuya K, Matsuo Y, Nakamura M, Shiinoki T, Mizowaki T, Hiraoka M
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 84(2) Pages: 369-375

    • DOI

      doi: 10.1016/j.ijrobp.2011.12.026

    • Peer Reviewed
  • [Journal Article] Preliminary report of late recurrences, at 5 years or more, after stereotactic body radiation therapy for non-small cell lung cancer.2012

    • Author(s)
      Matsuo Y, Shibuya K, Nagata Y, Norihisa Y, Narabayashi M, Sakanaka K, Ueki N, Mizowaki T, Hiraoka M
    • Journal Title

      J Thoracic Oncol

      Volume: 7(2): Pages: 453-456

    • DOI

      doi: 10.1097/JTO.0b013e31823c5b29

    • Peer Reviewed
  • [Journal Article] JNK regulates the photic response of the mammalian circadian clock2012

    • Author(s)
      Yoshitane H et al.
    • Journal Title

      EMBO Report

      Volume: Vol.13 Pages: 445-461

    • DOI

      doi: 10.1038/embor.2012.37

    • Peer Reviewed
  • [Journal Article] 術前臨床データによる小型肺癌に対する縮小手術の適応2012

    • Author(s)
      樋田泰浩、寺村鉱一、武藤潤、大高和人、長谷龍之介、中田玲子、渡邊祐介、松居喜郎、加賀基知三
    • Journal Title

      胸部外科

      Volume: 65 Pages: 52-57

  • [Presentation] 動体追跡技術による全身の時計遺伝子発現定量解析と行動解析2013

    • Author(s)
      浜田俊幸
    • Organizer
      第155回日本獣医学会学術大会
    • Place of Presentation
      東京大学駒場キャンパス(東京都)
    • Year and Date
      20130328-20130330
  • [Presentation] 動体追跡技術による全身の時計遺伝子発現定量解析と行動解析2013

    • Author(s)
      浜田俊幸
    • Organizer
      155回日本獣医学会大会
    • Place of Presentation
      東京大学駒場キャンパス(東京都)
    • Year and Date
      20130328-20130330
    • Invited
  • [Presentation] 標的原子核破砕反応と高精度陽子線がん治療に関する研究2013

    • Author(s)
      西尾禎治、松下慶一郎、関根雅晃、宮武彩
    • Organizer
      日本物理学会第68回年次大会
    • Place of Presentation
      広島大学(東広島市)
    • Year and Date
      20130326-20130329
  • [Presentation] Development of RTP System with the Plug-in Function for Various Radiation Therapy System2013

    • Author(s)
      T. Nishio
    • Organizer
      Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique, Symposium
    • Place of Presentation
      Convention Center(Hokkaido)
    • Year and Date
      20130207-20130208
    • Invited
  • [Presentation] A Mathematical Method for Estimating Optimal Fractionation Regimen in Radiotherapy2013

    • Author(s)
      Seishin Takao, Masahiro Mizuta, Hiroyuki Date, Yuriko Komiya, Kenneth L. Sutherland, Rikiya Onimaru, and Hiroki Shirato
    • Organizer
      3rd International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
    • Place of Presentation
      Hokkaido University(Sapporo)
    • Year and Date
      20130207-20130208
  • [Presentation] Involvement of cell polarity and cell migration in folding phenomena of epithelial sheets2012

    • Author(s)
      S. Ishida, R. Tanaka, N. Yamaguchi, T. Mizutani, K. Kawabata, H. Haga
    • Organizer
      第52回米国細胞生物学会年会
    • Place of Presentation
      モスコーンセンター(米国)
    • Year and Date
      20121215-20121219
  • [Presentation] EGFR and Integrin α2β1 Dependent Invasiveness of Lung Adenocarcinoma Cells that Survived 10 Gy Ionizing Radiation2012

    • Author(s)
      X. Li, S. Ishihara, M. Yasuda, T. Mizutani, K. Kawabata, T. Nishioka, H. Haga
    • Organizer
      第52回米国細胞生物学会年会
    • Place of Presentation
      モスコーンセンター(米国)
    • Year and Date
      20121215-20121219
  • [Presentation] Collective behavior of epithelial cells responding to stiffness, roughness and composition of extracellular matrix2012

    • Author(s)
      芳賀 永
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      20121211-20121214
    • Invited
  • [Presentation] Multiple components of prefrontal signals for covert tracking of moving object2012

    • Author(s)
      田中真樹
    • Organizer
      The 3rd International Symposium on Prefrontal Cortex- Searching for Mechanism of Mind
    • Place of Presentation
      Kyoto Univ Inamori Cntr.(京都市)
    • Year and Date
      20121129-20121130
    • Invited
  • [Presentation] Naming rule in radiation therapy and its efficacy2012

    • Author(s)
      安田耕一, 鈴木隆介, 藤田勝久, 清水伸一, 鬼丸力也, 加藤徳雄, 木下留美子, 西岡健太郎, 原田慶一, 白土博樹
    • Organizer
      日本放射線腫瘍学会 第25回学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      20121123-20121124
  • [Presentation] 子宮頸癌に対する根治的化学放射線療法の検討2012

    • Author(s)
      原田慶一、木下留美子、西岡健太郎、小野寺俊輔、土屋和彦、加藤徳雄、清水伸一、白土博樹、長谷川雅一、北原利博
    • Organizer
      日本放射線腫瘍学会 第25回学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      20121123-20121124
  • [Presentation] Study on Radiation Therapy with Distribution Valued Data2012

    • Author(s)
      M. Mizuta
    • Organizer
      3rd Workshop in Symbolic Data Analysis
    • Place of Presentation
      Madrid, Comillas Pontifical University(Spain)
    • Year and Date
      20121107-20121109
  • [Presentation] Stereotactic body radiotherapy (SBRT) using real-time tracking radiotherapy (RTRT) system for patients with lung cancer aged 80 and over2012

    • Author(s)
      Onimaru R, Katoh N, Inoue T, Shimizu S, Shinagawa N, Sakakibara-Konishi J, Oizumi S, Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] Decreasing acute and late toxicity using urethral dose reduction and smaller safety margin around CTV for prostate cancer intensity-modulated radiation therapy (IMRT)2012

    • Author(s)
      Shimizu S, Nishioka K, Onimaru R, Kinoshita R, Harada K, Nishikawa N, Abe T, Maruyama S, Shinohara N, Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] Retrospective comparison between Cisplatin plus fluorouracil and weekly Cisplatin in concurrent chemotherapy setting for stage II-IV nasopharyngeal carcinoma2012

    • Author(s)
      Tsuchiya K, Yasuda K, Nishikawa Y, Kinoshita R, Onimaru R, Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] Real-time tumor tracking radiation therapy for lymphoma of the stomach2012

    • Author(s)
      Katoh N, Suzuki R, Shimizu S, Inoue T, Yasuda K, Onimaru R, Kimura R, Kato M, Ishikawa M, Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] Interfractional setup error and intrafractional bladder motion during radiotherapy for bladder tumors2012

    • Author(s)
      Nishioka K, Shimizu S, Abe T, Maruyama S, Onimaru R, Kinoshita R, Harada K, Nishikawa N, Shinohara N, Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] Stereotactic body radiotherapy using gated radiotherapy with real-time tumor-tracking for stage I non-small cell lung cancer2012

    • Author(s)
      Inoue T, Katoh N, Onimaru R, Suzuki R, Sakakibara-Konishi J, Shinagawa N, Oizumi S, Hiroki Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] The role of spot scanning proton therapy in the treatment of large abdominal tumors: A comparative planning study of hepatocellular carcinoma2012

    • Author(s)
      Toramatsu C, Katoh N, Shimizu S, Nihongi H, Matsuura T, Takao S, Miyamoto N, Kinoshita R, Umegaki K, Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] Co-overexpression Of GEP100 With EGFR Correlates With Early Recurrence After Breast Conservation Therapy (BCT)2012

    • Author(s)
      Kinoshita R, Nam JM, Hosoda M, Kubota KC, Tanino M, Hashimoto A, Ito YM, Tanaka S, Sabe H, Shirato H
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] Targeting beta1 integrin suppresses invasive recurrence in a three-dimensional model of radiation treated ductal carcinoma in situ2012

    • Author(s)
      Nam JM, Ahmed KM, Costes S, Zhang H, Sabe H, Shirato H, Park CC
    • Organizer
      ASTRO 54th Annual meeting
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] Phase II study of nimotuzumab in combination with concurrent chemoradiation therapy (CRT) in patients with locally advanced non-small cell lung cancer (NSCLC). (abstract: Int J Radiat Oncol Biol Phys, 84(3, Suppl): S68, 2012)2012

    • Author(s)
      Nishimura Y, Harada H, Soejima T, Tsujino K, Hayakawa K, Kozuka T, Tanaka M, Sasaki T, Yamamoto N, Nakagawa K
    • Organizer
      54th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
    • Year and Date
      20121028-20121031
  • [Presentation] 特別講演1.癌の診断・治療効果評価におけるPETの応用~基礎研究を中心に~ 口腔顔面核医学フォーラム20122012

    • Author(s)
      趙松吉、久下裕司、玉木長良
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Year and Date
      20121011-20121013
    • Invited
  • [Presentation] 腫瘍・肉芽腫における18F-FMISO集積の特徴:18F-FDG及び組織学的比較2012

    • Author(s)
      趙松吉、伊敏、趙芫、西嶋剣一、村上正紘、于聞文、チョウドリ ヌスラット ファティマ、孫田恵、小華和柾志、玉木長良、久下裕司
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      20121011-20121013
  • [Presentation] 固形腫瘍内における放射線誘導性再酸素化の動態の評価2012

    • Author(s)
      永根大幹、安井博宣、趙松吉、久保直樹、玉木長良、久下裕司、稲波修
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      20121011-20121013
  • [Presentation] The relationship between the pretreatment uptake area of FMISO and local recurrence site in nasopharyngeal cancer2012

    • Author(s)
      Yasuda K, Tsuchiya K, Okamoto S, Onimaru R, Shiga T, Katoh N, Suzuki R, Harada K, Kuge Y, Tamaki N, Shirato H
    • Organizer
      The 10th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      北海道医学部学友会館「フラテ」(札幌市)
    • Year and Date
      20121002-20121003
  • [Presentation] Novel noninvasive imaging of clock gene expression in the olfactory bulbs and skin of freely moving mice2012

    • Author(s)
      Hamada T
    • Organizer
      The 10th International Symposium for Future Drug Discovery and Medical Care" Frontiers of Interdisciplinary Research in Medicine
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20121002-20121003
  • [Presentation] 転移性脳腫瘍症例における全脳照射後の1年以内のQOLの変化について2012

    • Author(s)
      小野寺俊輔、青山英史、鬼丸力也、白土博樹
    • Organizer
      第48回日本医学放射線学会 秋季臨床大会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Year and Date
      20120928-20120930
  • [Presentation] 低酸素イメージングと放射線治療2012

    • Author(s)
      安田耕一、鬼丸力也、岡本祥三、志賀哲、加藤徳雄、玉木長良、白土博樹
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      20120919-20120921
  • [Presentation] 放射線治療の最前線と癌治療2012

    • Author(s)
      白土博樹
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      20120919-20120921
  • [Presentation] A stiff substrate activates transcription factor NF-B and increases the adhesion area in cancer cells2012

    • Author(s)
      石原 誠一郎、安田 元昭、芳賀 永
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      さっぽろ芸文館(北海道)
    • Year and Date
      20120919-20120921
  • [Presentation] Monitoring the circadian clock’s tick; multiple hands for multiple functions.2012

    • Author(s)
      Sato Honma
    • Organizer
      4th International Symposium on Photonic Bioimaging
    • Place of Presentation
      Hokkaido University Conference Center(Sapporo)
    • Year and Date
      20120916-20120917
  • [Presentation] 中枢時計の発達と時計遺伝子機能2012

    • Author(s)
      小野大輔
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      北海道大学学術交流会館(札幌市)
    • Year and Date
      20120915-20120916
  • [Presentation] In vivo4Dイメージングによる覚醒マウス時計遺伝子発現定量解析2012

    • Author(s)
      浜田俊幸
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      北海道大学学術交流会館(札幌市)
    • Year and Date
      20120915-20120916
  • [Presentation] In vivo 4Dイメージングによる覚醒マウスの時計遺伝子発現定量解析2012

    • Author(s)
      浜田俊幸
    • Organizer
      第19回日本時間生物学術大会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20120915-20120916
  • [Presentation] 陽子線治療における最適な治療ワークフローの検討2012

    • Author(s)
      高尾聖心, 松浦妙子, 寅松千枝, 二本木英明, 宮本直樹, 清水伸一, 木下留美子, 松田浩二, 木谷貴雄, 梅垣菊男, 白土博樹
    • Organizer
      第104回日本医学物理学会大会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Year and Date
      20120913-20120915
  • [Presentation] 腫瘍の放射線治療における数理モデルについて2012

    • Author(s)
      水田正弘、高尾聖心、伊達 広行、白土 博樹
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20120909-20120912
  • [Presentation] 分布値データ解析のための数学的ツールについて2012

    • Author(s)
      水田正弘
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20120909-20120912
  • [Presentation] FLT can early reflect response of tumor proliferation to multikinase inhibitor (sorafenib) treatment in a human renal cell carcinoma xenograft: comparison with Ki-672012

    • Author(s)
      Murakami M, Zhao S, Zhao Y, Nusrat C, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y
    • Organizer
      The 2012 World Molecular Imaging Congress
    • Place of Presentation
      The Convention Centre Dublin - CCD( Ireland)
    • Year and Date
      20120905-20120908
  • [Presentation] On-line PET imaging for proton therapy system2012

    • Author(s)
      M. Yamada, D. Amano, T. Tachikawa, M. Hirabayashi, T. Nishio
    • Organizer
      22nd International Conference on the Application of Accelerators in Research and Industry (CAARI 2012)
    • Place of Presentation
      Renaissance Worthington Hotel(USA)
    • Year and Date
      20120805-20120810
  • [Presentation] Optimization of Dose Fractionation based on 3D dose distribution and LQ model2012

    • Author(s)
      M. Mizuta
    • Organizer
      The 31st Sapporo International Cancer Symposium 2012
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20120723-20120724
    • Invited
  • [Presentation] Invasive migration of irradiation-survived human lung adenocarcinoma cells in 3D matrix2012

    • Author(s)
      芳賀 永
    • Organizer
      第31回札幌国際がんシンポジウム
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20120723-20120724
    • Invited
  • [Presentation] Performace of beam ON-LINE PET system constructed with two opposing planar-type detector heads in proton therapy2012

    • Author(s)
      T. Nishio, A. Miyatake, K. Matsushita, M. Sekine
    • Organizer
      The 31st Sapporo International Cancer Symposium / Advanced Radiation Therapy and Cancer Research Up-to-Date
    • Place of Presentation
      Hokkaido University(Sapporo)
    • Year and Date
      20120723-20120724
  • [Presentation] Development of dynamic phantom for quality control in four-dimensional radiotherapy2012

    • Author(s)
      N. Miyamoto, Y. Hirata, K. Naoe, R. Suzuki, C. Toramatsu, S. Shimizu, Y. Miyabe, S. Kaneko, T. Nishio, M. Ishikawa, M. Hiraoka, H. Shirato
    • Organizer
      The 31st Sapporo International Cancer Symposium / Advanced Radiation Therapy and Cancer Research Up-to-Date
    • Place of Presentation
      Hokkaido University(Sapporo)
    • Year and Date
      20120723-20120724
  • [Presentation] Usability of Treatment Procedure in Spot Scanning Proton Beam Therapy System2012

    • Author(s)
      Seishin Takao, Shinichi Shimizu, Taeko Matsuura, Chie Toramatsu, Hideaki Nihongi, Naoki Miyamoto, Koji Matsuda, Toru Umekawa, Kikuo Umegaki, and Hiroki Shirato
    • Organizer
      31st Sapporo International Cancer Symposium
    • Place of Presentation
      Hokkaido University(Sapporo)
    • Year and Date
      20120723-20120724
  • [Presentation] 覚醒マウスにおける時計遺伝子発現の4Dイメージング2012

    • Author(s)
      浜田俊幸
    • Organizer
      第2回睡眠研究会
    • Place of Presentation
      名古屋大学(名古屋市)
    • Year and Date
      20120705-20120706
    • Invited
  • [Presentation] 覚醒マウスにおける時計遺伝子発現の4Dイメージング2012

    • Author(s)
      浜田俊幸
    • Organizer
      第2回睡眠研究会
    • Place of Presentation
      名古屋大学シンポジオン(名古屋市)
    • Year and Date
      20120704-20120705
  • [Presentation] MultiTransmitとSmart Exam Breastを用いた3T乳腺MRIの画質評価2012

    • Author(s)
      加藤扶美 真鍋徳子 水戸寿々子 石坂欣也 小野寺祐也 三村理恵 寺江 聡 白土博樹
    • Organizer
      第20回日本乳癌学会学術総会
    • Place of Presentation
      市民会館崇城大学ホール(熊本県)
    • Year and Date
      20120627-20120630
  • [Presentation] Dosimetric Comparison of Intensity Modulated Radiotherapy and Standard Wedged Tangential Technique for Whole-Breast Radiotherapy with Relatively Small Breast Volume2012

    • Author(s)
      Tsuchiya K, Kinoshita R, Nishioka K, Shimizu S, Shirato H
    • Organizer
      The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      20120619-20120621
  • [Presentation] Optimization of energy window setting of the semiconductor PET for clinical FDG studies2012

    • Author(s)
      Shiga T, Takeuchi W, Morimoto Y, Kubo N, Hirata K, Kobasi K, Hattori N, Tamaki N
    • Organizer
      The 59th Annual Meeting, Society of Nuclear Medicine
    • Place of Presentation
      Miami, the Miami Beach Convention Center(US)
    • Year and Date
      20120609-20120613
  • [Presentation] Reproducibility of hypoxic evaluation using FMISO-PET for head and neck cancer2012

    • Author(s)
      Okamoto S, Shiga T, Yasuda K, Kasai K, Magota K, Kuge K, Shirato H, Tamaki
    • Organizer
      The 59th Annual Meeting, Society of Nuclear Medicine
    • Place of Presentation
      Miami, the Miami Beach Convention Center(US)
    • Year and Date
      20120609-20120613
  • [Presentation] FMISO PET reflects antiangiogenic tumor response to multi-kinase inhibitor (sorafenib) in human renal cell carcinoma xenograft2012

    • Author(s)
      Murakami M, Zhao S, Zhao Y, Nusrat C, Yu W, Nishijima K, Takiguchi T, Tamaki N, Kuge Y
    • Organizer
      The 59th Annual Meeting, Society of Nuclear Medicine
    • Place of Presentation
      Miami, the Miami Beach Convention Center(US)
    • Year and Date
      20120609-20120613
  • [Presentation] Radiation-induced nitric oxide contributes to the tumor reoxygenation in SCCVII tumors2012

    • Author(s)
      Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Kameya H, Nakamura H, and Inanami O N, Kuge Y
    • Organizer
      The 59th Annual Meeting, Society of Nuclear Medicine
    • Place of Presentation
      Miami, the Miami Beach Convention Center(US)
    • Year and Date
      20120609-20120613
  • [Presentation] Substrate stiffness enhances MMP-7 expression and ECM degradation in cancer cells2012

    • Author(s)
      佐々木 千絵、桝田 浩孝、中村 公則、綾部 時芳、水谷 武臣、川端 和重、芳賀 永
    • Organizer
      第64回日本細胞生物学会大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      20120528-20120531
  • [Presentation] Involvement of cell polarity in folding phenomena of epithelial sheets2012

    • Author(s)
      石田 すみれ、田中 良昌、水谷 武臣、川端 和重、芳賀 永
    • Organizer
      第64回日本細胞生物学会大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      20120528-20120531
  • [Presentation] Integrin α2 dependent increased invasiveness of lung adenocarcinoma cells that survived 10 Gy ionizing radiation2012

    • Author(s)
      李 雪、石原 誠一郎、山田 泰士、安田 元昭、水谷 武臣、川端 和重、西岡 健、芳賀 永
    • Organizer
      第64回日本細胞生物学会大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      20120528-20120531
  • [Presentation] Live cell imaging of collective migration in 3D morphogenesis of epithelial cells2012

    • Author(s)
      今井 美沙子、水谷 武臣、川端 和重、芳賀 永
    • Organizer
      第64回日本細胞生物学会大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      20120528-20120531
  • [Presentation] Modeling of Radiation-Induced Bystander Effect with Re-emitting Signals Following the Poisson Statistics2012

    • Author(s)
      K. Sasaki, H. Date, T. Tsujiguchi, K. Wakui and A. Itoh
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing International Convention Center, Beijing(China)
    • Year and Date
      20120526-20120531
  • [Presentation] Analysis of Cell Surviving Fraction with Non-Lethal Probability for Radiation Exposure2012

    • Author(s)
      Kosuke Wakui, Kohei Sasaki, Hiroyuki Date
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing International Convention Center, Beijing(China)
    • Year and Date
      20120526-20120531
  • [Presentation] Signal integration of circadian neuronal networks.2012

    • Author(s)
      Sato Honma
    • Organizer
      Society for Research on Biological Rhythms Biannual meeting
    • Place of Presentation
      Sandestin Resort (USA)
    • Year and Date
      20120519-20120524
  • [Presentation] Suprachiasmatic nucleus output couplings.2012

    • Author(s)
      Sato Honma
    • Organizer
      Society for Research on Biological Rhythms Biannual meeting
    • Place of Presentation
      Sandestin Resort (USA)
    • Year and Date
      20120519-20120524
  • [Presentation] 生物時計の発達と睡眠覚醒リズム:時間生物学の小児科学への応用2012

    • Author(s)
      本間さと
    • Organizer
      日本小児神経学会
    • Place of Presentation
      札幌ロイトンホテル(北海道)
    • Year and Date
      20120517-20120519
  • [Presentation] Design of Treatment Workflow in a Proton Therapy System with Compact Rotating Gantry2012

    • Author(s)
      Seishin Takao, Shinichi Shimizu, Chie Toramatsu, Taeko Matsuura, Hideaki Nihongi, Naoki Miyamoto, Koji Matsuda, Toru Umekawa, Kikuo Umegaki, and Hiroki Shirato
    • Organizer
      51st Annual Meeting of Particle Therapy Co-Operative Group
    • Place of Presentation
      COEX(Seoul)
    • Year and Date
      20120514-20120519
  • [Presentation] Continuous monitoring of circadian clock’ s tick in the suprachiasmatic neurons.2012

    • Author(s)
      Sato Honma
    • Organizer
      International Syposium on Frontiers in Sleep and Biological Rhythms’ Research
    • Place of Presentation
      Dokuz Eylul University Izmir (Turkey)
    • Year and Date
      20120430-20120502
  • [Presentation] Treatment outcome of radiation therapy for breast cancer: The Hokkaido University Hospital experience2012

    • Author(s)
      Kinoshita R, Shimizu S, Nishioka K, Harada K, Onodera S, Hosoda M, Taguchi K, Takahashi H, Shirato H
    • Organizer
      第71回 日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      20120413-20120415
  • [Presentation] 胃悪性リンパ腫に対する迎撃照射とマーカー移動の解析2012

    • Author(s)
      加藤徳雄、鈴木隆介、井上哲也、安田耕一、鬼丸力也、清水伸一、木村理奈、石川正純、白土博樹
    • Organizer
      第71回 日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      20120413-20120413
  • [Presentation] Upcoming Dynamic Real-time Tumor-tracking for Lung Cancer: A Preliminary Study of its Validity

    • Author(s)
      Rie Yamazaki, Seiko Nishioka, Hiroyuki Date, Takao Koike, Hiroki Shirato, Takeshi Nishioka
    • Organizer
      Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
    • Place of Presentation
      Sapporo Convention Center(Hokkaido)
  • [Presentation] A Mathematical Method for Estimating Optimal Fractionation Regimen in Radiotherapy

    • Author(s)
      Seishin Takao, Masahiro Mizuta, Hiroyuki Date, Yuriko Komiya, Kenneth L. Sutherland, Rikiya Onimaru, Hiroki Shirato
    • Organizer
      Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
    • Place of Presentation
      Sapporo Convention Center(Hokkaido)
  • [Presentation] タイミング予測の神経機構

    • Author(s)
      田中真樹
    • Organizer
      システム神経科学セミナーシリーズ第4回
    • Place of Presentation
      国立精神神経センター神経研究所(東京都)
    • Invited
  • [Presentation] タイミング予測の神経機構

    • Author(s)
      田中真樹
    • Organizer
      第15回山形めまい研究会
    • Place of Presentation
      山形国際ホテル(山形県)
    • Invited
  • [Presentation] 小脳の時間情報処理:行動特性を支配するゲノム基盤と脳機能の解明

    • Author(s)
      田中真樹
    • Organizer
      平成24年度 京都大学霊長類研究所共同利用研究会
    • Place of Presentation
      京都大学霊長類研究所(愛知県)
    • Invited
  • [Presentation] 自発性サッカードのタイミング制御におけるドパミンの関与

    • Author(s)
      國松 淳, 田中真樹
    • Organizer
      第6回生理研Motor Control研究会
    • Place of Presentation
      生理学研究所(愛知県)
  • [Presentation] オドボール課題遂行中のサル視床ニューロンの予期的活動

    • Author(s)
      松山 圭, 國松 淳, 田中真樹
    • Organizer
      第6回生理研Motor Control研究会
    • Place of Presentation
      生理学研究所(愛知県)
  • [Presentation] サル前頭眼野の電気刺激による物体選択の操作.複数の刺激位置を記憶するための神経機構

    • Author(s)
      松嶋藻乃, 田中真樹
    • Organizer
      包括脳ワークショップ
    • Place of Presentation
      仙台国際センター(仙台市)
  • [Presentation] 線条体ドパミンによる自発的な運動のタイミング調節

    • Author(s)
      國松 淳, 田中真樹
    • Organizer
      第92回日本生理学会北海道地方会
    • Place of Presentation
      北海道大学(札幌市)
  • [Presentation] Saccade target selection determines direction of cerebellar adaptation

    • Author(s)
      Habtemariam A, 松嶋藻乃, 田中真樹
    • Organizer
      第92回日本生理学会北海道地方会
    • Place of Presentation
      北海道大学(札幌市)
  • [Presentation] 記憶すべき複数刺激の相対位置により異なる二つの符号化

    • Author(s)
      松嶋藻乃,田中真樹
    • Organizer
      第92回日本生理学会北海道地方会
    • Place of Presentation
      北海道大学(札幌市)
  • [Presentation] 即時的な行動選択に関わる淡蒼球の神経活動

    • Author(s)
      吉田篤司, 田中真樹
    • Organizer
      第92回日本生理学会北海道地方会
    • Place of Presentation
      北海道大学(札幌市)
  • [Presentation] サル視床ニューロンにおける反応性から予測性への活動変化

    • Author(s)
      松山 圭, 國松 淳, 田中真樹
    • Organizer
      第92回日本生理学会北海道地方会
    • Place of Presentation
      北海道大学(札幌市)
  • [Presentation] Long-term follow-up Study about Preventive Effect of H. pylori Eradication for the Incidence of Metachronous Gastric Cancer after Endoscopic Resection of Primary Early Gastric Cancer.

    • Author(s)
      Kato M, Kikuchi S, Asaka M.
    • Organizer
      DDW2012
    • Place of Presentation
      Convention Center (USA)
  • [Presentation] NSAID/Aspirin induced small intestinal injury.

    • Author(s)
      Kato M,
    • Organizer
      APDW2012
    • Place of Presentation
      Queen Sirkit National Convention Center (Bangkok)
    • Invited
  • [Presentation] A randomized controlled study for the third-line rescuer therapy after failure of two H. pylori eradication in Japan.

    • Author(s)
      Kato M, Murakami K, Furuta T.
    • Organizer
      XXVth Internationa Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      The Grand Union Hotel(Ljubljana)
  • [Presentation] The identification for high risk group of gastric cancer using serum pepsinogen after successful eradication of H. pylori

    • Author(s)
      Kato M, Haneda M, Ishigaki S, Suzuki M, Takahashi M, Ono S, Mabe K, Shimizu Y
    • Organizer
      UEGW 2012
    • Place of Presentation
      Amsterdam RAI(Amsterdam)
  • [Presentation] Insertion and fixation of gold markers using new disposable insertion system for Real-Time Tumor-Tracking Radiotherapy against lung cancer

    • Author(s)
      Naofumi Shinagawa
    • Organizer
      World Congress of Bronchology
    • Place of Presentation
      Cleveland(USA)
  • [Presentation] Insertion and fixation of gold markers using new disposable insertion system for Real-Time Tumor-Tracking Radiotherapy against lung cancer

    • Author(s)
      Naofumi Shinagawa
    • Organizer
      3rd International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
    • Place of Presentation
      札幌コンベンションセンター(北海道)
  • [Presentation] Clinical outcomes of concurrent chemoradiotherapy using cisplatin and vinorelbine for stage III non-small cell lung cancer. International Conference Center Hiroshima, Japan, July 19th -21st, 2012

    • Author(s)
      Souda I, Hayakawa K, Ishiyama H, Niibe Y, Komori S, Sekiguchi A, Igawa S, Mitsufuji H, Katagairi M, Masuda N
    • Organizer
      The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      広島国際会議場(広島市)
  • [Presentation] Development of fast and high-spatial-resolution 3-dimensional dosimetry equipment for both the narrow beam and the broad beam in proton therapy. (abstract: Int J Radiat Oncol Biol Phys, 84(3, Suppl): S55, 2012)

    • Author(s)
      Nakamura S, Asai H, Akita S, Aoyama Y, Kamikubo Y, Sugama Y, Takei H, Nishio T, Maruyama K, Hayakawa K
    • Organizer
      54th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO)
    • Place of Presentation
      Boston Convention and Exhibition Center(USA)
  • [Presentation] 肺癌の放射線治療

    • Author(s)
      澁谷 景子
    • Organizer
      第47回日本呼吸器学会中国・四国地方会
    • Place of Presentation
      海峡メッセ下関(下関市)
    • Invited
  • [Presentation] 肝胆膵

    • Author(s)
      澁谷 景子
    • Organizer
      JASTRO日本放射線腫瘍学会 第14回放射線腫瘍学夏季セミナー
    • Place of Presentation
      九州大学医学部百年記念講堂(福岡市)
    • Invited
  • [Presentation] 放射線治療の最前線

    • Author(s)
      澁谷 景子
    • Organizer
      国際膵臓シンポジウム2012 市民公開講座
    • Place of Presentation
      国立京都国際会館アネックスホール(京都市)
    • Invited
  • [Presentation] 肺癌の克服に向けて―将来への提言―

    • Author(s)
      澁谷 景子
    • Organizer
      第53回日本肺癌学会総会
    • Place of Presentation
      ホテルグランヴィア岡山(岡山市)
    • Invited
  • [Presentation] 体内時計による全身の時計遺伝子発現リズム調節機構解明へー 光イメージングを用いてのアプローチ

    • Author(s)
      浜田俊幸
    • Organizer
      先端的光イメージング研究拠点形成プロジェクト 研究成果報告シンポジウム
    • Place of Presentation
      北海道大学(札幌市)
  • [Presentation] 動体追跡法による覚醒マウス脳内遺伝子発現の定量解析に関する研究

    • Author(s)
      浜田俊幸
    • Organizer
      早稲田大学先進理工学部生理・薬理研究室セミナー
    • Place of Presentation
      早稲田大学(東京都)
    • Invited
  • [Presentation] 覚醒マウス嗅球および皮膚における時計遺伝子発現の4Dイメージング

    • Author(s)
      浜田俊幸
    • Organizer
      北海道医学大会生理系分科会
    • Place of Presentation
      北海道大学(札幌市)
  • [Presentation] 原発巣へのFDG集積による非浸潤性非小細胞癌の判定

    • Author(s)
      武藤 潤,樋田泰浩,加賀基知三,加藤達哉,大高和人,井上 玲,中田玲子,平野 聡,松居喜郎
    • Organizer
      第29回日本呼吸器外科学会総会
    • Place of Presentation
      秋田県民会館(秋田市)
  • [Presentation] 非小細胞肺癌患者におけるSUV補正の有鞘性の検討

    • Author(s)
      大高和人,樋田泰浩,長谷龍之介,武藤潤,中田玲子,加賀基知三,松居喜郎
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
  • [Book] MT標準臨床検査学「臨床医学総論」II 放射性同位元素検査技術学 第1章 放射線同位元素の物理と計測装置2013

    • Author(s)
      伊達 広行
    • Total Pages
      208-219
    • Publisher
      医学書院
  • [Book] DOJIN SCIENCE SERIES 02 時間生物学2012

    • Author(s)
      本間 さと
    • Total Pages
      55-65
    • Publisher
      科学同人
  • [Book] 日本放射線腫瘍学会・日本放射線腫瘍学研究機構・編:臨床放射線腫瘍学-最新知見に基づいた放射線治療の実践-2012

    • Author(s)
      早川和重(分担)
    • Total Pages
      300-305
    • Publisher
      南江堂,東京
  • [Book] 日本放射線腫瘍学会編・放射線治療計画ガイドライン2012年版2012

    • Author(s)
      早川和重(分担)
    • Total Pages
      123-128
    • Publisher
      金原出版,東京
  • [Book] Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy, Applied Biological Engineering - Principles and Practice2012

    • Author(s)
      Takao S, Tadano S, Taguchi H, and Shirato H. (分担)
    • Total Pages
      662(うち29-46)
    • Publisher
      InTech
  • [Remarks] 空間的注意

    • URL

      http://bsd.neuroinf.jp/wiki/

URL: 

Published: 2014-07-24  

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