Research for Real-time Tracking Medical Science

2012 Fiscal Year Final Research Report

• Project/Area Number: 21249065
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: SHIRATO Hiroki 北海道大学, 大学院・医学研究科, 教授 (20187537)
• Co-Investigator(Kenkyū-buntansha): HONMA Sato 北海道大学, 大学院・医学研究科, 特任教授 (20142713) ; TAMAKI Nagara 北海道大学, 大学院・医学研究科, 教授 (30171888) ; KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958) ; MIZUTA Masahiro 北海道大学, 情報科学研究科, 教授 (70174026) ; DATE Hiroyuki 北海道大学, 大学院・保健科学研究院, 教授 (10197600) ; TANAKA Masaki 北海道大学, 大学院・医学研究科, 教授 (90301887) ; HAGA Hisashi 北海道大学, 大学院・先端生命科学研究院, 准教授 (00292045) ; NISHIOKA Takeshi 北海道大学, 大学院・保健科学研究院, 教授 (80271659) ; KATO Motothugu 北海道大学, 北海道大学病院, 准教授 (60271673) ; CHAMOTO Kenji 北海道大学, 遺伝子病制御研究所, 助教 (50447041) ; OIZUMI Satoshi 北海道大学, 北海道大学病院, 准教授 (10421968) ; MATSUNAGA Naofumi 山口大学, 医学部, 教授 (40157334) ; OKIMOTO Tomoaki 北海道がんセンター, 診療部長 (20295067) ; HAYAKAWA Kazushige 北里大学, 医学部, 教授 (70114189) ; NISHIO Teiji 独立行政法人国立がん研究センター, 臨床開発センター粒子線医学開発部粒子線生物学室, 室長 (40415526) ; TADANO Shigeru 北海道大学, 大学院・工学研究科, 教授 (50175444) ; ISHIKAWA Masayori 北海道大学, 大学院・医学研究科, 教授 (80314772) ; ONODERA Yasuhito 北海道大学, 大学院・医学研究科, 助教 (90435561) ; SHIBUYA Keiko 山口大学, 医学部, 教授 (50335262) ; HAMADA Toshiyuki 北海道大学, 大学院・医学研究科, 特任講師 (20360208) ; ONIMARU Rikiya 北海道大学, 大学院・医学研究科, 准教授 (80374461) ; SHIMIZU Shinichi 北海道大学, 大学院・医学研究科, 特任准教授 (50463724) ; TSUCHIYA Kazuhiko 北海道大学, 北海道大学病院, 准教授 (60580892) ; KATOH Norio 北海道大学, 大学院・医学研究科, 助教 (80572495) ; KINOSHITA Rumiko 北海道大学, 大学院・医学研究科, 特任助教 (70507582) ; INOUE Tetsuya 北海道大学, 北海道大学病院, 助教 (10431363) ; ONODERA Syunsuke 北海道大学, 大学院・医学研究科, 特任助教 (30374458) ; TAKAO Seishin 北海道大学, 大学院・医学研究科, 助教 (10614216) ; KAGA Kichizo 北海道大学, 北海道大学病院, 講師 (80224335)
• Co-Investigator(Renkei-kenkyūsha): TERAE Satoshi 北海道大学, 北海道大学病院, 准教授 (40240634) ; ONODERA Yuya 北海道大学, 北海道大学病院, 講師 (10272064) ; SAKUHARA Yusuke 北海道大学, 北海道大学病院, 助教 (40374459) ; MANABE Noriko 北海道大学, 北海道大学病院, 講師 (70463742) ; ABO Daisuke 北海道大学, 北海道大学病院, 助教 (30399844) ; KATO Fumi 北海道大学, 北海道大学病院, 助教 (80399865) ; KHIN KHIN Tha 北海道大学, 大学院・医学研究科, 特任助教 (20451445) ; NAM Jin-min 北海道大学, 大学院・医学研究科, 特任助教 (60414132) ; SABE Hisataka 北海道大学, 大学院・医学研究科, 教授 (40187282) ; INUBUSHI Masayuki (独)放射線医学総合研究所, 分子イメージング研究センター, 研究員 (70399830) ; SHINAGAWA Naofumi 北海道大学, 大学院・医学研究科, 助教 (20431372) ; KENNETH Sutherland 北海道大学, 大学院・医学研究科, 助教 (30451446)
• Project Period (FY): 2009 – 2012
• Keywords: 放射線治療 / 動体追跡 / 医学研究 / 生体の動き

Research Abstract

Up to now, in the field of basic medicine from micro-level to animal level, to track and quantify the three-dimensional spatial information along the time axis in real-time has not caught up with the accuracy in the field of clinical medicine. By handing big data of “motion in life, a new idea of real-time radiotherapy and a new precise four-dimensional computed tomography has been developed based on the data of actual tumor motion in the human body.

Research Products

• [Journal Article] Symptomatic Outcomes in Relation to Tumor Expansion After Fractionated Stereotactic Radiation Therapy for Vestibular Schwannomas: Single-Institutional Long-Term Experience (2013)
  • Author(s): Aoyama H, Onodera S, Takeichi N, Onimaru R, Terasaka S, Sawamura Y, Shirato H
  • Journal Title: Int J Radiat Oncol BiolPhys Volume: 1;85(2) Pages: 329-334
  • DOI: doi:10.1016/j.ijrobp.2012.05.003
  • Peer Reviewed
• [Journal Article] High reproducibility of tumor hypoxia evaluated by18F-fluoromisonidazole PET for head and neck cancer (2013)
  • Author(s): Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato H, Tamaki N
  • Journal Title: J Nucl Med Volume: 54 Pages: 201-207
  • DOI: doi:10.2967/jnumed.112.109330.
  • Peer Reviewed
• [Journal Article] Irradiation-tolerant Lung Cancer Cells Acquire Invasive Ability Dependent on Dephosphorylation of the Myosin Regulatory Light Chain (2013)
  • Author(s): S. Ishihara, M. Yasuda, T. Nishioka, T. Mizutani, K. Kawabata, H. Shirato and H. Haga
  • Journal Title: FEBS Letters Volume: 587 Pages: 732-736
  • Peer Reviewed
• [Journal Article] Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning (2012)
  • Author(s): Masahiro Mizuta, Hiroyuki Date, Seishin Takao, Naoki Kishimoto, Kenneth L. Sutherland, Rikiya Onimaru, and Hiroki Shirato
  • Journal Title: Medical Physics Volume: 39 (11) Pages: 6791-6795
  • DOI: doi:10.1118/1.4757580
  • Peer Reviewed
• [Journal Article] Neuronal correlates of multiple top-down signals during covert tracking of moving objects in macaque prefrontal cortex (2012)
  • Author(s): Matsushima, A. & Tanaka, M.
  • Journal Title: J. Cogn. Neurosci Volume: 24 Pages: 2043-2056
  • DOI: doi:10.4236/cellbio.2012.11001
  • Peer Reviewed
• [Journal Article] Recent Develop -ment of Gastric Cancer Prevention (2012)
  • Author(s): Kato M, Asaka M
  • Journal Title: Jpn J Clin Oncol Volume: 42 Pages: 987-994
• [Journal Article] Rab5c promotes AMAP1-PRKD2 complex formation to enhance ss1 integrin recycling in EGF-induced cancer invasion (2012)
  • Author(s): Onodera Y, Nam JM, Hashimoto A, Norman JC, Shirato H, Hashimoto S, Sabe H
  • Journal Title: J Cell Biol Volume: 197 Pages: 983-996
• [Journal Article] Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus (2012)
  • Author(s): Enoki R, Kuroda S, Ono C, Hasan MT, Honma S, Ueda T and Honma K
  • Journal Title: Proc.Natl. Acad.Sci USA Volume: 109 Pages: 21498-21503
  • DOI: doi:10.1073/pnas.1214415110
  • Peer Reviewed
• [Journal Article] Phase I study of concurrentreal-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer (2011)
  • Author(s): Sakakibara-Konishi J, Oizumi S, Kinoshita I, Shinagawa N, Kikuchi J, Kato M, Inoue T, Katoh N, Onimaru R, Shirato H, Dosaka-Akita H, Nishimura M
  • Journal Title: Lung Cancer Volume: 74(2) Pages: 248-252
  • Peer Reviewed
• [Journal Article] Use of implanted markers and interportal adjustment with real-time tracking radiotherapy system to reduce intrafraction prostate motion (2011)
  • Author(s): Shimizu S, Osaka Y, Shinohara N, Sazawa A, Nishioka K, Suzuki R, Onimaru R, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 81(4) Pages: 393-399
  • DOI: doi10.1016/j.ijrobp.2011.04.043
  • Peer Reviewed
• [Journal Article] Relationship Between Diseased Lung Tissues on Computed Tomography and Motion of Fiducial Marker Near Lung Cancer (2011)
  • Author(s): Onodera Y, Nishioka N, Yasuda K, Fujima N, Torres M, Kamishima T, Ooyama N, Onimaru R, Terae S, Oizumi S, Nishimura M, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 79 (5) Pages: 1408-1413
  • DOI: doi:10.1016/j.ijrobp.2010.01.008
  • Peer Reviewed
• [Journal Article] X-ray Diffraction as a Promising Tool to Characterize Bone Nanocomposites (2011)
  • Author(s): Tadano,S., Giri, B.
  • Journal Title: Science and Technology of Advanced Materials Volume: 12-6 Pages: 064708
  • Peer Reviewed
• [Journal Article] The development and clinical use of a beam ON-LINE PET system mounted on a rotating gantry port in proton therapy (2010)
  • Author(s): T. Nishio, A. Miyatake, T. Ogino, K.Nakagawa, N. Saijo, H. Esumi
  • Journal Title: Int. J. Radiat. Oncol. Biol. Phys Volume: 76(1) Pages: 277-286
  • Peer Reviewed
• [Presentation] 動体追跡技術による全身の時計遺伝子発現定量解析と行動解析 (2013)
  • Author(s): 浜田俊幸,石川正純,Kenneth Sutherland,宮本直樹,白土博樹,本間さと,本間研一
  • Organizer: 第155回日本獣医学会大会
  • Place of Presentation: 東京大学
  • Year and Date: 2013-03-28
• [Presentation] Insertion and fixation of gold markers using new disposable insertion system for Real-Time Tumor-Tracking Radiotherapy against lung cancer (2013)
  • Author(s): Oizumi S, Shinagawa N, Yamada N, Asahina H, Sakakibara-Konishi J, Inoue T, Kato N, Shirato H
  • Organizer: 3^<rd> International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2013-02-08
• [Presentation] Invasive Migration ofIrradiation Survived Human LungAdenocarcinoma Cells in 3D Matrix (2012)
  • Author(s): 芳賀永
  • Organizer: 第31回札幌国際がんシンポジウム(招待講演)
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 20120723-24
• [Presentation] Microdosimetric Kinetic Analysis of the Lesions in Bio-Cells by Radiation Exposure (2011)
  • Author(s): Y. Ohtsubo, K. Tsutsumi, K. Sasaki, K.Wakui, and H. Date
  • Organizer: PROGRAMME GUIDE & BOOK OF ABSTRACTS of 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: Warsaw, Poland, The Palace of Culture and Science
  • Year and Date: 20110828-901
• [Presentation] Neural mechanism oftiming: a role for the cerebellum (2011)
  • Author(s): Tanaka,M.
  • Organizer: David Mahoney Center Laboratory Seminar. Organized by Michael E Goldberg. New York
  • Place of Presentation: Columbia University Medical Center
  • Year and Date: 2011-11-17
• [Presentation] IGRTにPETを用いるための基礎研究。シンポジウム高精度放射線治療におけるPET/CTの役割 (2011)
  • Author(s): 久下裕司
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場(つくば)
  • Year and Date: 2011-10-29
• [Presentation] The beam ON-LINE PETsystem mounted on a rotating gantry port for proton therapy in NationalCancer Center. Kashiwa (2009)
  • Author(s): T. Nishio, A. Miyatake, T. Tachikawa,M. Yamada
  • Organizer: PTCOG 48
  • Place of Presentation: Heidelberg, University of Heidelberg, Germany
  • Year and Date: 20090928-1003
• [Presentation] Photic regulation of phase and tau; adaptive role of a kinase in the SCN (2009)
  • Author(s): Honma S
  • Organizer: Salve Regina Collage, New Port, Road Island
  • Place of Presentation: Gordon Conference on Chronobiology
  • Year and Date: 20090719-24
• [Book] Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy (2013)
  • Author(s): S. Takao, S. Tadano, H. Taguchi, H.Shirato
  • Total Pages: 662(29-46)
  • Publisher: Applied Biological Engineering - Principles and Practice
• [Book] 医学物理の理工学-上巻- (2012)
  • Author(s): 上坂充、中川恵一、西尾禎治、金井達明監修
  • Publisher: 養賢堂
• [Book] Thalamic roles in eye movements (2011)
  • Author(s): Tanaka, M. & Kunimatsu, J.
  • Total Pages: 235-256
  • Publisher: In: Oxford Handbook of Eye Movements (S.P. Liversedge, I.D. Glichrist, S. Everling, Eds.)
• [Book] Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy (2010)
  • Author(s): Kuge Y et al.
  • Total Pages: 19-29/303
  • Publisher: Tamaki N, Kuge Y eds. Springer (Springer Science+Business Media), Heidelberger
• [Book] Single cellneuronal circadian clocks (2009)
  • Author(s): Honma S and Honma K
  • Total Pages: 843-847
  • Publisher: Editor-in-Chief: LR. Squire, New Encyclopedia of Neuroscience, Elsevier
• [Patent(Industrial Property Rights)] ターゲット位置追跡装置およびターゲット発光検出装置 (2011)
  • Inventor(s): 石川正純、浜田俊幸 、本間研一、本間さと 、ケネス・リー・サザーランド
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Number: PCT/JP,2011/075225
  • Filing Date: 2011-11-01
  • Overseas
• [Patent(Industrial Property Rights)] ターゲット位置追跡装置およびターゲット発光検出装置 (2010)
  • Inventor(s): 石川正純、浜田俊幸 、本間研一、本間さと 、ケネス・リー・サザーランド
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Number: 特願,2010-245624
  • Filing Date: 2010-11-01