小児重症心不全の治療成績向上のための補助循環システムの開発に関する総合的研究

2013 Fiscal Year Annual Research Report

• Project/Area Number: 21249076
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: 巽 英介 独立行政法人国立循環器病研究センター, 研究所, 部長 (00216996)
• Co-Investigator(Kenkyū-buntansha): 妙中 義之 独立行政法人国立循環器病研究センター, 研究所, 副所長 (00142183) ; 増澤 徹 茨城大学, 工学部, 教授 (40199691)
• Project Period (FY): 2009-05-11 – 2014-03-31
• Keywords: 小児重症心不全 / 機械的補助循環 / 抗血栓性 / 補助人工心臓 / 経皮的心肺補助 / VAD / ECMO / PCPS

Research Abstract

本研究では、各種小児用補助循環システムの研究開発を行った。ECMO/PCPSシステムについては、動圧浮上非接触回転型として世界初のディスポ遠心ポンプを新規開発した（BIOFLOAT-NCVCと命名）。本ポンプは長期耐久性と優れた抗血栓性を実現するもので、充填量は15ccと超小型である。最大発生圧700mmHgと優れたポンプ性能を有しており、長期ECMO/PCPSや左心バイパスシステムなど様々な補助循環システムに応用できる。全血液接触面には我々が開発した強力な抗血栓性ヘパリン処理であるT-NCVCコーティングが施される。成山羊を用いた完全ヘパリン非投与下（ACT＜150秒）での慢性実験では、1ヶ月の連続PCPSを安定して施行することができた。2）体外設置式空気圧駆動型VADについては、1990年の製造承認後も使用実績がなかった国循型の小児用拍動流型VAD（M型）の臨床使用を可能とすべく、再度の開発・改良・評価を進めた。T-NCVCコーティングを施して抗血栓性を高め長期動物試験を行った結果、成山羊に対してワーファリンによる軽度の抗凝固療法施行下で3ヶ月間の左心補助を安定して行い得（GLP準拠試験）、薬事申請（一部変更申請）のための非臨床試験を完了して申請準備まで到達した。3）乳児用遠心式VADに関しては、茨城大学との共同研究開発により3次試作まで試作・評価を行い、製品化設計の段階に達した。4）動圧軸受け技術を用いた超小型体内埋込式軸流型VADの小児用改良については、小児用インペラを新たに製作して組み込んだ。また、解剖学的適合性向上のために新規の流入ポートを設計し、成人用から4cmのサイズ短縮に成功した。模擬循環回路での駆出性能評価では小児用としての設計通りの性能を得、また溶血試験評価でも優れた耐溶血性能を確認した。今後in vivo試験を含めて実用化に向けた準備を継続していく。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] 超耐久性小児用ECMOの研究開発と臨床応用 (2013)
  • Author(s): 齋藤友宏, 巽 英介, 片桐伸将, 武輪能明, 水野敏秀, 築谷朋典, 市川 肇, 鍵崎康治, 帆足孝也, 林 輝行, 吉田幸太郎, 妙中義之
  • Journal Title: 膜型肺 Volume: 34 Pages: 35-43
• [Journal Article] Insufflation of Hydrogen Gas Restrains the Inflammatory Response of Cardiopulmonary Bypass in a Rat Model (2013)
  • Author(s): Fujii Y, Shirai M, Inamori S, Shimouchi A, Sonobe T, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E. Taenaka Y
  • Journal Title: Artif Organs Volume: 37 Pages: 136-141
  • Peer Reviewed
• [Journal Article] In vivo evaluation of an in-body, tissue-engineered, completely autologous valved conduit (biovalve type VI) as an aortic valve in a goat model (2013)
  • Author(s): Takewa Y, Yamanami M, Kishimoto Y, Arakawa M, Kanda K, Matsui Y, Oie T, Ishibshi-Uchida H, Tajikawa T, Ohba K, Yaku H, Taenaka Y, Tatsumi E, Nakayama Y.
  • Journal Title: J Artif Organs Volume: 16 Pages: 176-184
  • Peer Reviewed
• [Journal Article] Development and evaluation of endurance test system for ventricular assist devices (2013)
  • Author(s): Sumikura H, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mukaibayashi H, Katano K, Tatsumi E
  • Journal Title: J Artif Organs Volume: 16 Pages: 138-148
  • Peer Reviewed
• [Journal Article] Development of a novel drive mode to prevent aortic insufficiency during continuous-flow LVAD support by synchronizing rotational speed with heartbeat (2013)
  • Author(s): Kishimoto Y, Takewa Y, Arakawa M, Umek A, Ando M, Nishimura T, Fujii Y, Mizuno T, Nishimura M, Tatsumi E
  • Journal Title: J Artif Organs Volume: 16 Pages: 129-137
  • Peer Reviewed
• [Journal Article] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models (2013)
  • Author(s): Umeki A, Nishimura T, Takewa Y, Ando M, Arakawa M, Kishimoto Y, Tsukiya T, Mizuno T, Kyo S, Ono M, Taenaka Y, Tatsumi E
  • Journal Title: J Artif Organs Volume: 16 Pages: 119-128
  • Peer Reviewed
• [Journal Article] Early clinical outcomes of new pediatric extracorporeal life support system (Endumo(A (R)) 2000) in neonates and infants (2013)
  • Author(s): Hoashi T, Kagisaki K, Yamashita K, Tatsumi E, Nishigaki T;, Yoshida K, Hayashi T, Ichikawa H
  • Journal Title: J Artif Organs Volume: 16 Pages: 267-272
  • Peer Reviewed
• [Journal Article] Change of Coronary Flow by Continuous-Flow Left Ventricular Assist Device With Cardiac Beat Synchronizing System (Native Heart Load Control System) in Acute Ischemic Heart Failure Model (2013)
  • Author(s): Umeki A, Nishimura T, Ando M, Takewa Y, Yamazaki K, Kyo S, Ono M, Tsukiya T, Mizuno T, Taenaka Y, Tatsumi E
  • Journal Title: Circulation Journal Volume: 77 Pages: 995-1000
  • Peer Reviewed
• [Journal Article] Hyperoxic Condition Promotes an Inflammatory Response During Cardiopulmonary Bypass in a Rat Model (2013)
  • Author(s): Fujii Y, Shirai M, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E, Taenaka Y.
  • Journal Title: Artif Organs Volume: 37 Pages: 1034-1040
  • Peer Reviewed
• [Journal Article] Journal of Artificial Organs 2012: the year in review (2013)
  • Author(s): Sawa, Y, Tatsumi E, Tsukiya T, Matsuda K, Fukunaga K, Kishida A, Masuzawa T, Matsumiya G, Myoui A; Nishimura, M; Nishimura, T; Nishinaka, T; Okamoto, E; Tokunaga, S; Tomo, T; Yagi, Y; Yamaoka, T.
  • Journal Title: J Artif Organs Volume: 16 Pages: 1-8
• [Journal Article] 右心補助を目指した定常流型左室補助人工心臓による心拍同期回転数制御システムの開発 (2013)
  • Author(s): 荒川 衛, 武輪能明, 西村 隆, 巽 英介
  • Journal Title: 人工臓器 Volume: 42 Pages: 37-38
• [Journal Article] A novel couterpulsation mode of rotary left ventricular assist devices can enhance myocarcial perfusion (2013)
  • Author(s): 安藤政彦, 武輪能明, 西村 隆, 山崎健二, 許 俊鋭, 小野 稔, 築谷朋典 ,水野敏秀, 妙中義之, 巽 英介
  • Journal Title: 人工臓器 Volume: 42 Pages: 19-21
• [Journal Article] 先進医療機器の研究開発・臨床応用・製品化における課題 (2013)
  • Author(s): 巽 英介
  • Journal Title: アカデミア発医療イノベーション－All Japanパラダイムシフト－講演集 Volume: 1 Pages: 26-37
• [Journal Article] 院内外搬送が可能なモバイルECMOシステムのための人工心肺用移動架台の開発と臨床応用 (2013)
  • Author(s): 片桐伸将, 巽 英介, 林 輝行, 吉田幸太郎, 柳園宜紀, 小林 進, 妙中義之
  • Journal Title: 膜型肺 Volume: 34 Pages: 28-34
• [Journal Article] 新生児・乳幼児に対する超低充填量心肺 (2013)
  • Author(s): 吉田幸太郎, 林 輝行, 高橋裕三, 松本泰史, 四井田英樹, 西垣孝行, 小川浩司, 西岡 宏, 帆足孝也, 鍵崎康治, 市川 肇, 片桐伸将, 巽 英介
  • Journal Title: 膜型肺 Volume: 34 Pages: 44-51
• [Presentation] The effect or continuous-flow LVAD control with cardiac cycle synchronization (2013)
  • Author(s): Nishimura T, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Date K, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] Long-term evaluation of a durable and thrombo-resistant ECMO system consisting of BIOCUBE6000 and SOFTLINE coated RATAFLOW (2013)
  • Author(s): Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Atsuta Y, Kato Y, Taenaka Y.
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] Ethical issues of clinical trials of artificial hearts: past, present, and future (2013)
  • Author(s): Nakada H, Matsui K, Aizawa K, Muto K, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] Field investigation of the approaches to promote the development of orphan medical devices in the United States (2013)
  • Author(s): Ohya T, Akagawa E, Tatsumi E, Taenaka Y
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] Hyperoxia condition promotes an inflammatory response during extracorporeal circulation in a rat model (2013)
  • Author(s): Fujii Y, Tatsumi E, Shirai M, Takewa Y, Taenaka Y
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] Pathological changes in cardio-pulmonary tissue of the goat following prolonged venoarterial ECMO (2013)
  • Author(s): Mizuno T, Katagiri N, Tsukiya T, Takewa Y, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] The safe program for a newly developed electrocardiogram-synchronized rotational speed control mode with continuous-flow left ventricular assist device (2013)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Fujii Y, Kyo S, Adachi H, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] A non-invasive assessment of cardiac function during continuous-flow LVAD support by HRV analysis (2013)
  • Author(s): Kishimoto S, Kishimoto Y, Ohnuma K, Arakawa M, Date K, Takewa Y, Nishimura M, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] The potentially of non-synchronized pulsatile mode with a rotary LVAD by a native heart load control system (2013)
  • Author(s): Date K, Arakawa M, Takewa Y, Nishimura T, Kishimoto S, Kishimoto Y, Umeki A, Ando M, Kyo S, Ono M, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] Motor performance of magnetically levitated pediatric VAD (2013)
  • Author(s): Omori N, Masuzawa T, Osa M, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] Assessment of the cannula exit site infection in two different configuration, porous material covered vs non-covered tube (2013)
  • Author(s): Atsuta Y, Mizuno T, Takewa Y, Tsukiya T, Yanagisono Y, Kobara, Taenaka Y, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] In vitro performance of an miniaturized axial flow ventricular assist device (2013)
  • Author(s): Tsukiya T, Mizuno T, Hoshi H, Okubo T, Yamane T, Maruyama O, Takewa Y, Tatsumi E
  • Organizer: 日本人工臓器学会大会 (51), International Federation for Artificial Organs (5)
  • Place of Presentation: 横浜
  • Year and Date: 20130927-20130929
• [Presentation] In vitro evaluation of the hydrodynamically levitated centrifugal blood pump as a extracorporeal ventricular assist device (2013)
  • Author(s): Tsukiya T, Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Hoshi H, Okubo T, Tatsumi E, Taenaka Y
  • Organizer: International Society for Rotary Blood Pumps (21)
  • Place of Presentation: Yokohama
  • Year and Date: 20130926-20130928
• [Presentation] Long-term durability test of the developing axial-flow ventricular assist devices under pulsatile (2013)
  • Author(s): Nishida M, Kosaka R, Maruyama O, Yamane T, Okubo T, Hoshi H, Osada T, Tatsumi E, Taenaka Y
  • Organizer: International Society for Rotary Blood Pumps (21)
  • Place of Presentation: Yokohama
  • Year and Date: 20130926-20130928
• [Presentation] Optimization of ACT for in vitro antithrombogenic evaluation of a continuous flow pump (2013)
  • Author(s): Maruyama O, Kosaka R, Nishida M, Yamane T, Tatsumi E, Taenaka Y
  • Organizer: International Society for Rotary Blood Pumps (21)
  • Place of Presentation: Yokohama
  • Year and Date: 20130926-20130928
• [Presentation] Longtime pulsatile control using a rotary blood pump with a newly developed electrocardiogram synchronized rotational speed control system (2013)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Yamazaki K, Kyo S, Adachi H, Tatsumi E
  • Organizer: International Society for Rotary Blood Pumps (21)
  • Place of Presentation: Yokohama
  • Year and Date: 20130926-20130928
• [Presentation] The difference between front load and delay load in the pulsatile mode with a rotary LVAD by a native heart load control system (2013)
  • Author(s): Date K, Arakawa M, Takewa Y, Nishimura T, Kishimoto S, Kishimoto Y, Umeki A, Ando M, Kyo S, Ono M, Tatsumi E
  • Organizer: International Society for Rotary Blood Pumps (21)
  • Place of Presentation: Yokohama
  • Year and Date: 20130926-20130928
• [Presentation] Chronic animal test of the SUNMEDICAL EVAHEART with titanium meshed inflow cannula in accordance with good laboratory practic (2013)
  • Author(s): Mizuno T, Kitano T, Miyakoshi T, Tokuno T, Tsukiya T, Nishinaka T, Yamazaki K, Tatsumi E
  • Organizer: International Society for Rotary Blood Pumps (21)
  • Place of Presentation: Yokohama
  • Year and Date: 20130926-20130928
• [Presentation] Evaluation of long-term durability of a T-NCVC coated ECMO system with GYRO pump for cardiopulmonary support use (2013)
  • Author(s): Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Kobara D, Yanaginoso Y, Taenaka Y
  • Organizer: International Society for Rotary Blood Pumps (21)
  • Place of Presentation: Yokohama
  • Year and Date: 20130926-20130928
• [Presentation] Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation and decarboxylation (2013)
  • Author(s): Togo K, Takewa Y, Tsukiya T, Mizuno T, Katagiri N, Atsuta Y, Fujii Y, Kishimoto S, Date K, Sumikura H, Ohnuma K, Kakuta Y, Miyamoto Y, Tatsumi E
  • Organizer: International Society for Rotary Blood Pumps (21)
  • Place of Presentation: Yokohama
  • Year and Date: 20130926-20130928
• [Presentation] Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation (2013)
  • Author(s): Togo K, Atsuta Y, Fujii Y, Kakuta Y, Katagiri N, Kishimoto Y, Miyamoto T, Mizuno T, Ohnuma K, Sumikura H, Taenaka Y, Takewa Y, Tatsumi E, Tsukiya T
  • Organizer: European Society for Artificial Organs (40)
  • Place of Presentation: Glasgow
  • Year and Date: 20130911-20130914
• [Presentation] Evaluation of novel autologous heart valve (Biovalve Stent) for transcatheter aortic valve implantation (2013)
  • Author(s): Takewa Y, Kanada K, Nakayama Y, Sumikura H, Taenaka Y, Tajikawa T, Tatsumi E, Yamanami M
  • Organizer: European Society for Artificial Organs (40)
  • Place of Presentation: Glasgow
  • Year and Date: 20130911-20130914
• [Presentation] Can human biotubes be used as artificial vascular grafts? (2013)
  • Author(s): Nakayama Y, Takewa Y, Kaneko T, Yamanami M, Mizuno T, Kawajiri H, Okumura N, Hanada S, Kanda K, Tatsumi E
  • Organizer: European Society for Artificial Organs (40)
  • Place of Presentation: Glasgow
  • Year and Date: 20130911-20130914
• [Presentation] Novel stent eversion method for the preparation of autologous valve with stent (Stent-Biovalve) (2013)
  • Author(s): Mizuno T, Takewa Y, Sumikura H, Omura T, Tsujinaka T, Yamanami M, Tatsumi E, Nakayama Y
  • Organizer: European Society for Artificial Organs (40)
  • Place of Presentation: Glasgow
  • Year and Date: 20130911-20130914
• [Presentation] Development of a novel autologous valve with stent (Biovalve stent) for TAVI (2013)
  • Author(s): Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Ohnuma K, Sumikura H, Tajikawa T, Kanda K, Taenaka Y, Tatsumi E
  • Organizer: Heart Valve Society of America 7th Biennial congress
  • Place of Presentation: Venice
  • Year and Date: 20130622-20130625
• [Presentation] Systemic application of a completely autologous valved conduit (BIOVALVE Type VIII) prepared by in body tissue architecture technology in a goat model (2013)
  • Author(s): Nakayama Y, Takewa Y, Sumikura H, Yamanami M, Ohnuma K, Kanda K, Tatsumi E
  • Organizer: Heart Valve Society of America 7th Biennial congress
  • Place of Presentation: Venice
  • Year and Date: 20130622-20130625
• [Presentation] Development of a novel autologous valve with a stent (Biovalve stent) for transcatheter implantation (2013)
  • Author(s): Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Kishimoto S, Atsuta Y, Ohnuma K, Sumikura H, Mizuno T, Kanda K, Tajikawa T, Taenaka Y, Tatsumi E
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] In vivo evaluation of the percutaneous site of VAD system (2013)
  • Author(s): Atsuta Y, Mizuno T, Takewa Y, Tsukiya T, Kakuta Y, Katagiri N, Ohnuma K, Sumikura H, Fujii Y, Arakawa M, Togo K, Kishimoto S, Tatsumi E
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] Media coverage of revised act on organ transplantation in Japan (2013)
  • Author(s): Nakada H, Tatsumi E, Muto K, Taenaka Y
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] Enchantment of the myocardial perfusion by a novel cardiac cycle-synchronized rotation control mode in a continuous-flow in chronic ischemic heart failure model (2013)
  • Author(s): Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Date K, Atsuta Y, Fujii Y, Kishimoto S, Kyo S, Adachi H, Tatsumi E
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] Hydrogen gas suppresses systemic inflammatory response during cardiopulmonary bypass in a rat model (2013)
  • Author(s): ujii Y, Tatsumi E, Shirai M, Takewa Y, Taenaka Y
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] A proposal of flexible control algorithm for artificial heart based on stochastic method (2013)
  • Author(s): Ohnuma K, Sumikura H, Homma A, Tsukiya T, Mizuno T, Takewa Y, Akagawa E, Fukui Y, Tatsumi E
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] In vitro and in vivo evaluation of a compact wearable pneumatic drive unit for a ventricular assist device (2013)
  • Author(s): Sumikura H, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mizuno T, Tsukiya T, Katagiri N, Kakuta Y, Mukaibayashi H, Katano K, Kojima K, Fukui Y, Tatsumi E
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] Pathological observation in the goat following prolonged venoarterial bypass using an extracorporeal membrane oxygenation (2013)
  • Author(s): Mizuno T, Katagiri N, Tsukiya T, Takewa Y, Tatsumi E.
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] Practical operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation (2013)
  • Author(s): Togo K, Takewa Y, Mizuno T, Tsukiya T, Atsuta Y, Arakawa M, Kishimoto S, Katagiri N, Kakuta Y, Fujii Y, Sumikura H, Ohnuma K, Taenaka Y, Miyamoto Y, Tatsumi E
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] Evaluation of long-term durability of an antithrombogenic-coated ECMO system with Gyro pump (2013)
  • Author(s): Katagiri N, Tatsumi E, Takewa Y, Mizuno T, Tsukiya T, Kobara D, Yanagisono Y, Taenaka Y
  • Organizer: American Society for Artificial Internal Organs (59)
  • Place of Presentation: Chicago
  • Year and Date: 20130612-20130615
• [Presentation] Development of a tissue-compatible apical inflow cannula for an implantable VAD (2013)
  • Author(s): Mizuno T, Tsukiya T, Takewa Y, Tatsumi E
  • Organizer: International Society for Heart and Lung Transplantation Annual Meeting and Scientific Sessions (33)
  • Place of Presentation: Montreal
  • Year and Date: 20130424-20130427
• [Patent(Industrial Property Rights)] 人工肺システム (2013)
  • Inventor(s): 片桐伸将、巽 英介、妙中義之、小原大輔、内村智彦、柳園宜紀
  • Industrial Property Rights Holder: （独）国立循環器病研究センター／ニプロ株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2013-171220
  • Filing Date: 2013-08-21
• [Patent(Industrial Property Rights)] 血液ポンプ駆動制御器 (2013)
  • Inventor(s): 巽 英介, 武輪能明, 築谷朋典, 水野敏秀, 片桐伸将, 他
  • Industrial Property Rights Holder: （独）国立循環器病研究センター／ニプロ株式会社
  • Industrial Property Rights Type: 意匠
  • Industrial Property Number: 意匠登録第1487605号
  • Filing Date: 2013-06-06
  • Acquisition Date: 2013-11-29