2011 Fiscal Year Final Research Report
Development of drug delivery system for central nervous system
| Project/Area Number |
21249077
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
TOMINAGA Teiji 東北大学, 大学院・医系研究科, 教授 (00217548)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASE Toshiyuki 東北大学, 流体科学研究所, 教授 (30135313)
HAGA Youichi 東北大学, 大学院・医工学研究科, 教授 (00282096)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ドラッグデリバリー / リアルタイムモニタリング / MRI / シミュレーション / デバイス開発 |
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| Research Abstract |
This study aimed at developing novel brain interstitial drug delivery system for the treatment of central nervous system disorders. Recently we performed basic and clinical study using convection-enhanced delivery (CED). Convection-enhanced delivery (CED) is a local infusion technique that delivers various molecules to the central nervous system. We firstdeveloped real-time MRI guided monitoring system. In this system, we infuse the mixture of chemotherapeutic agent; ACNU with Gd-DTPA for real-time monitoring using MRI. Subsequently, we developed computational simulating system that predicts the distribution of Gd-DTPA in a brainstem of non-human primate. In addition, we developed a novel drug delivery apparatus.
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[Journal Article] IDH1/2 gene status defines the prognosis and molecular profiles in patients with grade III gliomas2011
Author(s)
Shibahara I, Sonoda Y, Kanamori M, Saito R, Yamashita Y, Kumabe T, Watanabe M, Suzuki H, Kato S, Ishioka C, Tominaga T
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Journal Title
Int J Clin Oncol
Volume: (Epub ahead of print)
Peer Reviewed
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[Journal Article] Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastomaxenografts2010
Author(s)
Yokosawa M, Sonoda Y, Sugiyama S, Saito R, Yamashita Y, Nishihara M, Satoh T, Kumabe T, Yokoyama M, Tominaga T
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Journal Title
Tohoku J Exp Med
Volume: 221(4)
Pages: 257-64
Peer Reviewed
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[Journal Article] Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[18F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new 18F-labeled 2-nitroimidazole analog2010
Author(s)
Shibahara I, Kumabe T, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T
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Journal Title
J Neurosurg
Volume: 113(2)
Pages: 358-68
Peer Reviewed
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[Presentation] Imaging of hypoxic lesion in glioma patients by PET with [18F]FRP-170, a new 18F-labeled 2-nitroimidazole analog2010
Author(s)
Kumabe T, Shibahara I, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T
Organizer
18th International Conference on Brain Tumor Research and Therapy
Place of Presentation
Travemunde, Germany
Year and Date
2010-05-19
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