2012 Fiscal Year Final Research Report
Studies of pathological involvement of Sox9 in osteoarthritis and discovery of new treatment for osteoarthritis
| Project/Area Number |
21249078
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YASODA Akihiro 京都大学, 医学研究科, 講師 (50378642)
ITO Hiromu 京都大学, 医学研究科, 准教授 (70397537)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 変形性関節症 / Sox9 / 遺伝子改変マウス |
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| Research Abstract |
Overexpression of Sox9 in articular chondrocytes resulted in delay of osteoarthritis change. In addition, genome-wide screening using GeneChip with chondrocytes derived mouse articular cartialge, Sox9-EGFP mice, and Sox9-EGFP null chimera identified one gene involved in osteoarthritis and one gene induced by Sox9. Furthermore, screening of about 10000 chemical reagents using Sox9-EGFP chondrocytes revealed 7 chemical reagents which has Sox9-indecing activity.
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[Journal Article] Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.2011
Author(s)
Yukio Nakamura, Koji Yamamoto, Xinjun He, Bungo Otsuki, Youngwoo Kim, Hiroki Murao, Tsunemitsu Soeda, Noriyuki Tsumaki, Jian Min Deng, Zhaoping Zhang, Richard R. Behringer, Benoit de Crombrugghe, John H. Postlethwait, Matthew L. Warman, Takashi Nakamura
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Journal Title
Nature Communications 2
Volume: Article number: 251
DOI
Peer Reviewed
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